Top

Published in:

Open Access 29-05-2023 | Human Immunodeficiency Virus | Mini-Review

Multi-functional auto-fluorescent nanogels for theranostics

Authors: Arti Vashist, Andrea D. Raymond, Prem Chapagain, Atul Vashist, Adriana Yndart Arias, Nagesh Kolishetti, Madhavan Nair

Published in: Journal of NeuroVirology | Issue 3/2023

Abstract

Here in the present article, the state of art for nanotechnology-enabled nanogel theranostics and the upcoming concepts in nanogel-based therapeutics are summarized. The benefits, innovation, and prospects of nanogel technology are also briefly presented.

Arjun P, Freeman JL, Kannan RR (2022) Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model. Heliyon 8:e10237CrossRefPubMedPubMedCentral

Asadian-Birjand M, Sousa-Herves A, Steinhilber D, Cuggino JC, Calderon M (2012) Functional nanogels for biomedical applications. Curr Med Chem 19:5029–5043CrossRefPubMed

Chen Y-B, Qiao T, Wang Y-Q, Cui Y-L, Wang Q-S (2022) Hydrogen bond-enhanced nanogel delivery system for potential intranasal therapy of Parkinson’s disease. Mater Des 219:110741CrossRef

Cho MH, Li Y, Lo P-C, Lee H, Choi Y (2020a) Fucoidan-based theranostic nanogel for enhancing imaging and photodynamic therapy of cancer. Nano-Micro Letters 12:47CrossRefPubMedPubMedCentral

Cho MH, Li Y, Lo P-C, Lee H, Choi Y (2020b) Fucoidan-based theranostic nanogel for enhancing imaging and photodynamic therapy of cancer. Nano-Micro Letters 12:1–15CrossRef

Cuggino JC, Blanco ERO, Gugliotta LM, Igarzabal CIA, Calderon M (2019) Crossing biological barriers with nanogels to improve drug delivery performance. J Control Release 307:221–246CrossRefPubMed

Gold V, Loening KL, McNaught AD, Shemi P (1997) IUPAC compendium of chemical terminology, 2nd edn. Blackwell Science, Oxford

Gyawali D, Kim JP, Yang J (2018) Highly photostable nanogels for fluorescence-based theranostics. Bioactive Materials 3:39–47CrossRefPubMed

Kaewruethai T, Laomeephol C, Pan Y, Luckanagul JA (2021) Multifunctional polymeric nanogels for biomedical applications. Gels 7:228CrossRefPubMedPubMedCentral

Kar M, Fechner L, Nagel G, Glitscher E, Rimondino GN, Calderón M (2017) Responsive nanogels for anti-cancer Therapy. Nanogels Biomed Appl 30:210CrossRef

Kaushik A, Yndart A, Atluri V, Tiwari S, Tomitaka A, Gupta P, Jayant RD, Alvarez-Carbonell D, Khalili K, Nair M (2019) Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection. Sci Rep 9:3928CrossRefPubMedPubMedCentral

Khalil IA, Harashima H (2023) Lipid‐based nanoparticles using cell‐penetrating peptides. Cell‐Penetrating Peptides: Design, Development and Applications 315–328

Kitayama Y, Yamada T, Kiguchi K, Yoshida A, Hayashi S, Akasaka H, Igarashi K, Nishimura Y, Matsumoto Y, Sasaki R (2022) In vivo stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy. J Mater Chem B 10:6784–6791CrossRefPubMed

Kolishetti N, Vashist A, Arias AY, Atluri V, Dhar S, Nair M (2022) Recent advances, status, and opportunities of magneto-electric nanocarriers for biomedical applications. Mol Aspects Med 83:101046. https://doi.org/10.1016/j.mam.2021.101046

Lee Y, Sugihara K, Gillilland MG III, Jon S, Kamada N, Moon JJ (2020) Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis. Nat Mater 19:118–126CrossRefPubMed

Li L, Qi Z (2021) Recent advances in cell‐mediated drug delivery systems for nanomedicine and imaging. Fund Drug Deliv 263–284

Lim E-K, Kim T, Paik S, Haam S, Huh Y-M, Lee K (2015) Nanomaterials for theranostics: recent advances and future challenges. Chem Rev 115:327–394CrossRefPubMed

Lin H-Y, Wang S-W, Mao J-Y, Chang H-T, Harroun SG, Lin H-J, Huang C-C, Lai J-Y (2021) Carbonized nanogels for simultaneous antibacterial and antioxidant treatment of bacterial keratitis. Chem Eng J 411:128469CrossRef

Liu Y, Zhao Z, Li M (2022) Overcoming the cellular barriers and beyond: recent progress on cell penetrating peptide modified nanomedicine in combating physiological and pathological barriers. Asian J Pharma Sci 17(4):523–543CrossRef

Lux J, White AG, Chan M, Anderson CJ, Almutairi A (2015) Nanogels from metal-chelating crosslinkers as versatile platforms applied to copper-64 PET imaging of tumors and metastases. Theranostics 5:277–288CrossRefPubMedPubMedCentral

Ma X, Li S-J, Liu Y, Zhang T, Xue P, Kang Y, Sun Z-J, Xu Z (2022). Bioengineered nanogels for cancer immunotherapy. Chem Soc Rev

Marrache S, Kumar Pathak R, Darley L, K, H Choi J, Zaver D, Kolishetti N, Dhar S (2013) Nanocarriers for tracking and treating diseases. Curr Med Chem 20:3500–3514CrossRefPubMedPubMedCentral

Mauro N, Scialabba C, Puleio R, Varvarà P, Licciardi M, Cavallaro G, Giammona G (2019) SPIONs embedded in polyamino acid nanogels to synergistically treat tumor microenvironment and breast cancer cells. Int J Pharm 555:207–219CrossRefPubMed

Nair M, Raymond A, Vashist A (2022) Biotherapy for viral infections using biopolymer based micro/nanogels. US Patent App 17/615,940

Osborne O, Peyravian N, Nair M, Daunert S, Toborek M (2020) The paradox of HIV blood–brain barrier penetrance and antiretroviral drug delivery deficiencies. Trends Neurosci 43:695–708CrossRefPubMedPubMedCentral

Pei M, Jia X, Zhao X, Li J, Liu P (2018) Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogel for cancer detection and treatment. Carbohyd Polym 183:131–139CrossRef

Ribovski L, de Jong E, Mergel O, Zu G, Keskin D, van Rijn P, Zuhorn IS (2021) Low nanogel stiffness favors nanogel transcytosis across an in vitro blood–brain barrier. Nanomed Nanotechnol Biol Med 34:102377

Topuz F, Uyar T (2022) Advances in the development of cyclodextrin-based nanogels/microgels for biomedical applications: drug delivery and beyond. Carbo Polym 120033

Vashist A, Atluri V, Raymond A, Kaushik A, Parira T, Huang Z, Durygin A, Tomitaka A, Nikkhah-Moshaie R, Vashist A, Agudelo M, Chand HS, Saytashev I, Ramella-Roman JC, Nair M (2020) Development of multifunctional biopolymeric auto-fluorescent micro- and nanogels as a platform for biomedical applications. Front Bioeng Biotechnol 8

Vashist A, Kaushik A, Madhavan NAIR, Florida International University FIU (2019) Micro/nano magnetic hydrogels with autofluorescence for therapeutic and diagnostic applications. U.S. Patent 10,344,100

Vashist A, Kaushik A, Vashist A, Bala J, Nikkhah-Moshaie R, Sagar V, Nair M (2018) Nanogels as potential drug nanocarriers for CNS drug delivery. Drug Discov Today 23(7):1436–1443CrossRefPubMedPubMedCentral

Vashist A, Kaushik AK, Ahmad S, Nair M (2017) Nanogels for biomedical applications. Royal Society of ChemistryCrossRef

Vdovchenko A (2022) Thermoresponsive poly-N-isopropylacrylamide nanogels for brain drug delivery

Vinogradov SV, Batrakova EV, Kabanov AV (2004) Nanogels for oligonucleotide delivery to the brain. Bioconjug Chem 15:50–60CrossRefPubMedPubMedCentral

Wang F, Xiao J, Chen S, Sun H, Yang B, Jiang J, Zhou X, Du J (2018a) Polymer vesicles: modular platforms for cancer theranostics. Adv Mater 30:1705674CrossRef

Wang H, Chen Q, Zhou S (2018b) Carbon-based hybrid nanogels: a synergistic nanoplatform for combined biosensing, bioimaging, and responsive drug delivery. Chem Soc Rev 47:4198–4232CrossRefPubMed

Yang J, Yao MH, Wen L, Song JT, Zhang MZ, Zhao YD, Liu B (2014) Multifunctional quantum dot-polypeptide hybrid nanogel for targeted imaging and drug delivery. Nanoscale 6:11282–11292CrossRefPubMed

Ye C, Cheng M, Ma L, Zhang T, Sun Z, Yu C, Wang J, Dou Y (2022) Oxytocin nanogels inhibit innate inflammatory response for early intervention in Alzheimer’s disease. ACS Appl Mater Interfaces 14:21822–21835CrossRefPubMed

Zhang Y, Zou Z, Liu S, Miao S, Liu H (2022) Nanogels as novel nanocarrier systems for efficient delivery of CNS therapeutics. Front Bioeng Biotechnol 10

Zhao C, Sun S, Li S, Am Lv, Chen Q, Jiang K, Jiang Z, Li Z, Wu A, Lin H (2022) Programmed stimuli-responsive carbon dot-nanogel hybrids for imaging-guided enhanced tumor phototherapy. ACS Appl Mater Interfaces 14:10142–10153CrossRefPubMed

Zhao Q, Zhang S, Wu F, Li D, Zhang X, Chen W, Xing B (2021) Rational design of nanogels for overcoming the biological barriers in various administration routes. Angew Chem Int Ed 60:14760–14778CrossRef

Title: Multi-functional auto-fluorescent nanogels for theranostics
Authors: Arti Vashist
Andrea D. Raymond
Prem Chapagain
Atul Vashist
Adriana Yndart Arias
Nagesh Kolishetti
Madhavan Nair
Publication date: 29-05-2023
Publisher: Springer International Publishing
Keyword: Human Immunodeficiency Virus
Published in: Journal of NeuroVirology / Issue 3/2023
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-023-01138-y

ACC 2024 Congress

Springer Medicine

Multi-functional auto-fluorescent nanogels for theranostics

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2023

Brain opportunistic infections and tumors in people living with HIV — still a challenge in efficient antiretroviral therapy era

HIV viremia contributes to neurocognitive impairments in persons who use cocaine

Case report of Usutu virus infection in an immunocompromised patient in Italy, 2022

Single nucleotide polymorphisms in aquaporin-4 associate with cognitive impairment status in people with HIV

Meningitis associated with HHV-7 in an Iranian immunocompetent adolescent girl

Disruption of the ADAM17/NF-κB feedback loop in astrocytes ameliorates HIV-1 Tat-induced inflammatory response and neuronal death