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Journal of NeuroVirology
Published in: Journal of NeuroVirology 3/2019

01-06-2019 | Human Immunodeficiency Virus | Review

HIV-associated neurodegeneration: exploitation of the neuronal cytoskeleton

Authors: Erin D. Wenzel, Valeria Avdoshina, Italo Mocchetti

Published in: Journal of NeuroVirology | Issue 3/2019

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Abstract

Human immunodeficiency virus-1 (HIV) infection of the central nervous system damages synapses and promotes axonal injury, ultimately resulting in HIV-associated neurocognitive disorders (HAND). The mechanisms through which HIV causes damage to neurons are still under investigation. The cytoskeleton and associated proteins are fundamental for axonal and dendritic integrity. In this article, we review evidence that HIV proteins, such as the envelope protein gp120 and transactivator of transcription (Tat), impair the structure and function of the neuronal cytoskeleton. Investigation into the effects of viral proteins on the neuronal cytoskeleton may provide a better understanding of HIV neurotoxicity and suggest new avenues for additional therapies.
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Metadata
Title
HIV-associated neurodegeneration: exploitation of the neuronal cytoskeleton
Authors
Erin D. Wenzel
Valeria Avdoshina
Italo Mocchetti
Publication date
01-06-2019
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 3/2019
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-019-00737-y

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