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Journal of NeuroVirology
Published in: Journal of NeuroVirology 3/2019

01-06-2019 | Zika Virus | Mini-Review

Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern

Authors: DeGaulle I. Chigbu, Pooja Jain, Brenndan L. Crumley, Dip Patel, Zafar K. Khan

Published in: Journal of NeuroVirology | Issue 3/2019

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Abstract

Human T cell leukemia virus type 1 (HTLV-1) and Zika virus (ZIKV) have been considered neglected viruses of low public health concern until recently when incidences of HTLV-1 and ZIKV were observed to be linked to serious immune-related disease and neurological complications. This review will discuss the epidemiology, genomic evolution, virus-host interactions, virulence factors, neuropathological sequelae, and current perspectives of these reemerging viruses. There are no FDA-approved therapeutics or vaccines against these viruses, and as such, it is important for clinical trials to focus on developing vaccines that can induce cell-mediated immune response to confer long-term protective immunity. Furthermore, attention should be paid to reducing the transmission of these viruses through unprotected sex, infected blood during sharing of contaminated needles, donated blood and organs, and vertical transmission from mother to baby via breastfeeding. There is an urgent need to re-evaluate repurposing current antiviral therapies as well as developing novel antiviral agents with enhanced efficacy due to the high morbidity rate associated with these two reemerging chronic viral diseases.
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Metadata
Title
Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern
Authors
DeGaulle I. Chigbu
Pooja Jain
Brenndan L. Crumley
Dip Patel
Zafar K. Khan
Publication date
01-06-2019
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 3/2019
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-019-00720-7

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