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01-10-2017 | Short Communication

First report of persistent dengue-1-associated autoimmune neurological disturbance: neuromyelitis optica spectrum disorder

Authors: Marzia Puccioni-Sohler, Alice M. M. Ornelas, Andrea S. de Souza, Mauro Jorge Cabral-Castro, Jessyca T.M.A. Ramos, Carolina Rosadas, Maria Cecilia F. Salgado, Alexandre A. Castiglione, Fernando Ferry, Jose Mauro Peralta, Carolina Moreira Voloch, Amilcar Tanuri, Fernanda Tovar-Moll, Renato Santana Aguiar

Published in: Journal of NeuroVirology | Issue 5/2017

Abstract

Dengue virus (DENV) causes immune-mediated diseases. Neurological involvement represents a severe condition that is rarely observed in DENV-1 infection. Neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) are idiopathic immune-mediated demyelinating syndromes of the central nervous system. We report a 17-year-old female with oligosymptomatic DENV-1 viremia, diagnosed as NMOSD. Magnetic resonance imaging showed spinal cord and brainstem lesions. Antibody for aquaporin 4 was negative. DENV-1 RNA infection was detected by serial RT-PCR and confirmed by phylogenetic analysis in serum. Although there are some reports of NMO post-dengue infection, there are not any published accounts of NMOSD with coexistent and persistent DENV-1 infection.

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Title: First report of persistent dengue-1-associated autoimmune neurological disturbance: neuromyelitis optica spectrum disorder
Authors: Marzia Puccioni-Sohler
Alice M. M. Ornelas
Andrea S. de Souza
Mauro Jorge Cabral-Castro
Jessyca T.M.A. Ramos
Carolina Rosadas
Maria Cecilia F. Salgado
Alexandre A. Castiglione
Fernando Ferry
Jose Mauro Peralta
Carolina Moreira Voloch
Amilcar Tanuri
Fernanda Tovar-Moll
Renato Santana Aguiar
Publication date: 01-10-2017
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 5/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0555-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

First report of persistent dengue-1-associated autoimmune neurological disturbance: neuromyelitis optica spectrum disorder

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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