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Published in:

01-04-2017

Cognitive function in early HIV infection

Authors: Aanchal Prakash, Jue Hou, Lei Liu, Yi Gao, Casey Kettering, Ann B. Ragin

Published in: Journal of NeuroVirology | Issue 2/2017

Abstract

This study aimed to examine cognitive function in acute/early HIV infection over the subsequent 2 years. Fifty-six HIV+ subjects and 21 seronegative participants of the Chicago Early HIV Infection Study were evaluated using a comprehensive neuropsychological assessment at study enrollment and at 2-year follow-up. Cognitive performance measures were compared in the groups using t tests and mixed-effect models. Patterns of relationship with clinical measures were determined between cognitive function and clinical status markers using Spearman’s correlations. At the initial timepoint, the HIV group demonstrated significantly weaker performance on measures of verbal memory, visual memory, psychomotor speed, motor speed, and executive function. A similar pattern was found when cognitive function was examined at follow-up and across both timepoints. The HIV subjects had generally weaker performance on psychomotor speed, executive function, motor speed, visual memory, and verbal memory. The rate of decline in cognitive function across the 2-year follow-up period did not differ between groups. Correlations between clinical status markers and cognitive function at both timepoints showed weaker performance associated with increased disease burden. Neurocognitive difficulty in chronic HIV infection may have very early onset and reflect consequences of initial brain viral invasion and neuroinflammation during the intense, uncontrolled viremia of acute HIV infection. Further characterization of the changes occurring in initial stages of infection and the risk and protective factors for cognitive function could inform new strategies for neuroprotection.

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Title: Cognitive function in early HIV infection
Authors: Aanchal Prakash
Jue Hou
Lei Liu
Yi Gao
Casey Kettering
Ann B. Ragin
Publication date: 01-04-2017
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 2/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0498-4

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Cognitive function in early HIV infection

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