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01-03-2017 | Original Article

Preoperative work-up for definition of lymph node risk involvement in early stage endometrial cancer: 5-year follow-up

Authors: Pietro Cignini, Salvatore Giovanni Vitale, Antonio Simone Laganà, Antonio Biondi, Valentina Lucia La Rosa, Giuseppe Cutillo

Published in: Updates in Surgery | Issue 1/2017

Abstract

This prospective cohort study aimed to analyze the accuracy of magnetic resonance imaging (MRI) and hysteroscopic excisional biopsy (HEB) for predicting the low- and high-risk patients with endometrial carcinoma for nodal involvement at preoperative evaluation. From January 2005 to December 2006, all patients with a diagnosis of endometrial carcinoma were prospectively included in the study and underwent pelvic MRI and HEB. The pelvic MRI (without contrast) was aimed to evaluate the extent of myometrial invasion (MI < 50%, MI ≥ 50%), the possible involvement of cervical stroma, the ovarian, and lymph nodes status. HEB was performed under general anesthesia, retrieving multiple biopsies through a 5-mm, monopolar, loop electrode. According to our data analysis, the integration of MRI and HEB showed an elevated accuracy and high rates of sensitivity (85.0%), specificity (88.5%), negative predictive value (91.9%) and positive predictive value (79.0%) in identifying low-risk patients who do not need comprehensive surgical staging.

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Title: Preoperative work-up for definition of lymph node risk involvement in early stage endometrial cancer: 5-year follow-up
Authors: Pietro Cignini
Salvatore Giovanni Vitale
Antonio Simone Laganà
Antonio Biondi
Valentina Lucia La Rosa
Giuseppe Cutillo
Publication date: 01-03-2017
Publisher: Springer Milan
Published in: Updates in Surgery / Issue 1/2017
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI: https://doi.org/10.1007/s13304-017-0418-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Preoperative work-up for definition of lymph node risk involvement in early stage endometrial cancer: 5-year follow-up

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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