Skip to main content
Top
Published in: Updates in Surgery 1/2011

01-03-2011 | Original Article

Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer: a case–control study

Authors: Marco Scatizzi, Katrin C. Kröning, Elisa Lenzi, Luca Moraldi, Stefano Cantafio, Francesco Feroci

Published in: Updates in Surgery | Issue 1/2011

Login to get access

Abstract

In a non-specialized setting, laparoscopic distal gastrectomy (LDG) for locally advanced diseases remains controversial, particularly given to the technical demands of the learning curve required to perform an adequate resection with D2 lymph node dissection. Inclusion criteria for this statistically generated matching controlled study were all patients who underwent subtotal laparoscopic gastrectomies from January 2006 until September 2009 for locally advanced gastric adenocarcinoma (stage II–IIIb), compared with matched patients who underwent the same procedure in an open fashion during the same period. Sixty case-matched patients were evaluated (30 laparoscopic vs. 30 open). Operative time was significantly longer (p < 0.05) for LDG. Benefits for LDG (p < 0.05) were observed among surgical short-term outcome (postoperative hospital stay, ambulation, first bowel movement, first flatus, first stool, first eating and use of analgesic drugs) and postoperative non-surgical site complications (cardiopulmonary, urinary, etc.). The 42 months’ overall survival was similar (p = 0.646). Laparoscopic gastrectomy is a safe technique in a non-academic hospital setting for locally advanced gastric cancer; it seems to be adequate in terms of margin status and adequate lymph node retrieval and is associated with additional benefits as a decreased length of hospital stay, a decreased narcotic use and fewer complications.
Literature
1.
go back to reference Nagai Y, Tanimura H, Takifuji K, Kashiwagi H, Yamoto H, Nakatani Y (1995) Laparoscope-assisted Billroth I gastrectomy. Surg Laparosc Endosc 5(4):281–287PubMed Nagai Y, Tanimura H, Takifuji K, Kashiwagi H, Yamoto H, Nakatani Y (1995) Laparoscope-assisted Billroth I gastrectomy. Surg Laparosc Endosc 5(4):281–287PubMed
2.
go back to reference Kitano S, Shimoda K, Miyahara M, Shiraishi N, Bandoh T, Yoshida T et al (1995) Laparoscopic approaches in the management of patients with early gastric carcinomas. Surg Laparosc Endosc 5(5):359–362PubMed Kitano S, Shimoda K, Miyahara M, Shiraishi N, Bandoh T, Yoshida T et al (1995) Laparoscopic approaches in the management of patients with early gastric carcinomas. Surg Laparosc Endosc 5(5):359–362PubMed
3.
go back to reference Uyama I, Sugioka A, Matsui H, Fujita J, Komori Y, Hasumi A (2000) Laparoscopic D2 lymph node dissection for advanced gastric cancer located in the middle or lower third portion of the stomach. Gastric Cancer 43(1):50–55CrossRef Uyama I, Sugioka A, Matsui H, Fujita J, Komori Y, Hasumi A (2000) Laparoscopic D2 lymph node dissection for advanced gastric cancer located in the middle or lower third portion of the stomach. Gastric Cancer 43(1):50–55CrossRef
4.
go back to reference Fleshman JW (2007) Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial. Ann Surg 246:655PubMedCrossRef Fleshman JW (2007) Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial. Ann Surg 246:655PubMedCrossRef
5.
go back to reference Rodríguez Santiago JM, Clemares M, Roig-Garcia J, Asensio JI, Feliu X, Toscano E et al (2009) Gastric cancer and laparoscopy: analysis of data from the National register of laparoscopic gastric surgery. Circ Esp 85(5):280–286CrossRef Rodríguez Santiago JM, Clemares M, Roig-Garcia J, Asensio JI, Feliu X, Toscano E et al (2009) Gastric cancer and laparoscopy: analysis of data from the National register of laparoscopic gastric surgery. Circ Esp 85(5):280–286CrossRef
6.
go back to reference Bonenkamp JJ, Hermans J, Sasako M, van de Velde CJ, Welvaart K, Songun I, Dutch Gastric Cancer Group et al (1999) Extended lymph-node dissection for gastric cancer. N Engl J Med 340(12):908–914PubMedCrossRef Bonenkamp JJ, Hermans J, Sasako M, van de Velde CJ, Welvaart K, Songun I, Dutch Gastric Cancer Group et al (1999) Extended lymph-node dissection for gastric cancer. N Engl J Med 340(12):908–914PubMedCrossRef
7.
go back to reference Cuschieri A, Weeden S, Fielding J, Bancewicz J, Craven J, Joypaul V et al (1999) Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical Co-operative Group. Br J Cancer 79(9–10):1522–1530PubMedCrossRef Cuschieri A, Weeden S, Fielding J, Bancewicz J, Craven J, Joypaul V et al (1999) Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical Co-operative Group. Br J Cancer 79(9–10):1522–1530PubMedCrossRef
8.
go back to reference Hartgrink HH, van de Velde CJ, Putter H, Bonenkamp JJ, Klein Kranenbarg E, Songun I et al (2004) Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial. J Clin Oncol 22(11):2069–2077PubMedCrossRef Hartgrink HH, van de Velde CJ, Putter H, Bonenkamp JJ, Klein Kranenbarg E, Songun I et al (2004) Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial. J Clin Oncol 22(11):2069–2077PubMedCrossRef
9.
go back to reference Wu CW, Hsiung CA, Lo SS, Hsieh MC, Chen JH, Li AF et al (2006) Nodal dissection for patients with gastric cancer: a randomised controlled trial. Lancet Oncol 7(4):309–315PubMedCrossRef Wu CW, Hsiung CA, Lo SS, Hsieh MC, Chen JH, Li AF et al (2006) Nodal dissection for patients with gastric cancer: a randomised controlled trial. Lancet Oncol 7(4):309–315PubMedCrossRef
10.
go back to reference Edwards P, Blackshaw GR, Lewis WG, Barry JD, Allison MC, Jones DR (2004) Prospective comparison of D1 vs modified D2 gastrectomy for carcinoma. Br J Cancer 90(10):1888–1892PubMedCrossRef Edwards P, Blackshaw GR, Lewis WG, Barry JD, Allison MC, Jones DR (2004) Prospective comparison of D1 vs modified D2 gastrectomy for carcinoma. Br J Cancer 90(10):1888–1892PubMedCrossRef
11.
go back to reference Biffi R, Chiappa A, Luca F, Pozzi S, Lo Faso F, Cenciarelli S et al (2006) Extended lymph node dissection without routine spleno-pancreatectomy for treatment of gastric cancer: low morbidity and mortality rates in a single center series of 250 patients. J Surg Oncol 93(5):394–400PubMedCrossRef Biffi R, Chiappa A, Luca F, Pozzi S, Lo Faso F, Cenciarelli S et al (2006) Extended lymph node dissection without routine spleno-pancreatectomy for treatment of gastric cancer: low morbidity and mortality rates in a single center series of 250 patients. J Surg Oncol 93(5):394–400PubMedCrossRef
12.
go back to reference Yildrim E, Celen O, Berberoglu U (2001) The Turkish experience with curative gastrectomies for gastric carcinoma: is D2 dissection worthwhile? J Am Coll Surg 192:25–37CrossRef Yildrim E, Celen O, Berberoglu U (2001) The Turkish experience with curative gastrectomies for gastric carcinoma: is D2 dissection worthwhile? J Am Coll Surg 192:25–37CrossRef
13.
go back to reference Degiuli M, Sasako M, Calgaro M, Garino M, Rebecchi F, Mineccia M, Italian Gastric Cancer Study Group et al (2004) Morbidity and mortality after D1 and D2 gastrectomy for cancer: interim analysis of the Italian Gastric Cancer Study Group (IGCSG) randomised surgical trial. Eur J Surg Oncol 30(3):303–308PubMed Degiuli M, Sasako M, Calgaro M, Garino M, Rebecchi F, Mineccia M, Italian Gastric Cancer Study Group et al (2004) Morbidity and mortality after D1 and D2 gastrectomy for cancer: interim analysis of the Italian Gastric Cancer Study Group (IGCSG) randomised surgical trial. Eur J Surg Oncol 30(3):303–308PubMed
14.
go back to reference Kodera Y, Sasako M, Yamamoto S, Sano T, Nashimoto A, Kurita A, Gastric Cancer Surgery Study Group of Japan Clinical Oncology Group (2005) Identification of risk factors for the development of complications following extended and superextended lymphadenectomies for gastric cancer. Br J Surg 92(9):1103–1109PubMedCrossRef Kodera Y, Sasako M, Yamamoto S, Sano T, Nashimoto A, Kurita A, Gastric Cancer Surgery Study Group of Japan Clinical Oncology Group (2005) Identification of risk factors for the development of complications following extended and superextended lymphadenectomies for gastric cancer. Br J Surg 92(9):1103–1109PubMedCrossRef
15.
go back to reference Clavien PA, Sanabria JR, Mentha G, Borst F, Buhler L, Bc Roche et al (1992) Recent results of elective open cholecystectomy in a North American and a European center. Comparison of complications and risk factors. Ann Surg 216(6):618–626PubMedCrossRef Clavien PA, Sanabria JR, Mentha G, Borst F, Buhler L, Bc Roche et al (1992) Recent results of elective open cholecystectomy in a North American and a European center. Comparison of complications and risk factors. Ann Surg 216(6):618–626PubMedCrossRef
16.
go back to reference Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD et al (2009) The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 250(2):187–196PubMedCrossRef Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD et al (2009) The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 250(2):187–196PubMedCrossRef
17.
go back to reference Ohgami M, Otani Y, Furukawa T, Kubota T, Kumai K, Kitajima M (2000) Curative laparoscopic surgery for early gastric cancer: eight years experience. Nippon Geka Gakkai Zasshi 101(8):539–545PubMed Ohgami M, Otani Y, Furukawa T, Kubota T, Kumai K, Kitajima M (2000) Curative laparoscopic surgery for early gastric cancer: eight years experience. Nippon Geka Gakkai Zasshi 101(8):539–545PubMed
18.
go back to reference Kitano S, Shiraishi N (2004) Current status of laparoscopic gastrectomy for cancer in Japan. Surg Endosc 18:182–185PubMedCrossRef Kitano S, Shiraishi N (2004) Current status of laparoscopic gastrectomy for cancer in Japan. Surg Endosc 18:182–185PubMedCrossRef
19.
go back to reference Adachi Y, Suematsu T, Shiraishi N, Katsuta T, Morimoto A, Kitano S et al (1999) Quality of life after laparoscopy-assisted Billroth I gastrectomy. Ann Surg 229(1):49–54PubMedCrossRef Adachi Y, Suematsu T, Shiraishi N, Katsuta T, Morimoto A, Kitano S et al (1999) Quality of life after laparoscopy-assisted Billroth I gastrectomy. Ann Surg 229(1):49–54PubMedCrossRef
20.
go back to reference Goh PM, Alponat A, Mak K, Kum CK (1997) Early international results of laparoscopic gastrectomies. Surg Endosc 11:650–652PubMedCrossRef Goh PM, Alponat A, Mak K, Kum CK (1997) Early international results of laparoscopic gastrectomies. Surg Endosc 11:650–652PubMedCrossRef
21.
go back to reference Adachi Y, Shiraishi N, Shiromizu A, Bandoh T, Aramaki M, Kitano S (2000) Laparoscopy-assisted Billroth I gastrectomy compared with conventional open gastrectomy. Arch Surg 135(7):806–810PubMedCrossRef Adachi Y, Shiraishi N, Shiromizu A, Bandoh T, Aramaki M, Kitano S (2000) Laparoscopy-assisted Billroth I gastrectomy compared with conventional open gastrectomy. Arch Surg 135(7):806–810PubMedCrossRef
22.
go back to reference Yano H, Monden T, Kinuta M, Nakano Y, Tono T, Matsui S et al (2001) The usefulness of laparoscopy-assisted distal gastrectomy in comparison with that of open distal gastrectomy for early gastric cancer. Gastric Cancer 4(2):93–97PubMedCrossRef Yano H, Monden T, Kinuta M, Nakano Y, Tono T, Matsui S et al (2001) The usefulness of laparoscopy-assisted distal gastrectomy in comparison with that of open distal gastrectomy for early gastric cancer. Gastric Cancer 4(2):93–97PubMedCrossRef
23.
go back to reference Yasuda K, Sonoda K, Shiroshita H, Inomata M, Shiraishi N, Kitano S (2004) Laparoscopically assisted distal gastrectomy for early gastric cancer in the elderly. Br J Surg 91(8):1061–1065PubMedCrossRef Yasuda K, Sonoda K, Shiroshita H, Inomata M, Shiraishi N, Kitano S (2004) Laparoscopically assisted distal gastrectomy for early gastric cancer in the elderly. Br J Surg 91(8):1061–1065PubMedCrossRef
24.
go back to reference Kim YW, Baik YH, Yun YH, Nam BH, Kim DH, Choi IJ et al (2008) Improved quality of life outcomes after laparoscopy-assisted distal gastrectomy for early gastric cancer: results of a prospective randomized clinical trial. Ann Surg 248(5):721–727PubMedCrossRef Kim YW, Baik YH, Yun YH, Nam BH, Kim DH, Choi IJ et al (2008) Improved quality of life outcomes after laparoscopy-assisted distal gastrectomy for early gastric cancer: results of a prospective randomized clinical trial. Ann Surg 248(5):721–727PubMedCrossRef
25.
go back to reference Hayashi H, Ochiai T, Shimada H, Gunji Y (2005) Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperigastric lymph node dissection for early gastric cancer. Surg Endosc 19(9):1172–1176PubMedCrossRef Hayashi H, Ochiai T, Shimada H, Gunji Y (2005) Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperigastric lymph node dissection for early gastric cancer. Surg Endosc 19(9):1172–1176PubMedCrossRef
26.
go back to reference Huscher CG, Mingoli A, Sgarzini G, Sansonetti A, Di Paola M, Recher A et al (2005) Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Ann Surg 241(2):232–237PubMedCrossRef Huscher CG, Mingoli A, Sgarzini G, Sansonetti A, Di Paola M, Recher A et al (2005) Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Ann Surg 241(2):232–237PubMedCrossRef
27.
go back to reference Lee JH, Han HS, Lee JH (2005) A prospective randomized study comparing open vs laparoscopy-assisted distal gastrectomy in early gastric cancer: early results. Surg Endosc 19(2):168–173PubMedCrossRef Lee JH, Han HS, Lee JH (2005) A prospective randomized study comparing open vs laparoscopy-assisted distal gastrectomy in early gastric cancer: early results. Surg Endosc 19(2):168–173PubMedCrossRef
28.
go back to reference Kitano S, Shiraishi N, Fujii K, Yasuda K, Inomata M, Adachi Y (2002) A randomized controlled trial comparing open vs laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer: an interim report. Surgery 131(1 Suppl):S306–S311PubMedCrossRef Kitano S, Shiraishi N, Fujii K, Yasuda K, Inomata M, Adachi Y (2002) A randomized controlled trial comparing open vs laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer: an interim report. Surgery 131(1 Suppl):S306–S311PubMedCrossRef
29.
go back to reference Kim HH, Hyung WJ, Cho GS, Kim MC, Han SU, Kim W et al (2010) Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report—a phase III multicenter, prospective, randomized trial (KLASS trial). Ann Surg 251(3):417–420PubMedCrossRef Kim HH, Hyung WJ, Cho GS, Kim MC, Han SU, Kim W et al (2010) Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report—a phase III multicenter, prospective, randomized trial (KLASS trial). Ann Surg 251(3):417–420PubMedCrossRef
30.
go back to reference Ohtani H, Tamamori Y, Noguchi K, Azuma T, Fujimoto S, Oba H et al (2010) A meta-analysis of randomized controlled trials that compared laparoscopy-assisted and open distal gastrectomy for early gastric cancer. J Gastrointest Surg 14(6):958–964PubMedCrossRef Ohtani H, Tamamori Y, Noguchi K, Azuma T, Fujimoto S, Oba H et al (2010) A meta-analysis of randomized controlled trials that compared laparoscopy-assisted and open distal gastrectomy for early gastric cancer. J Gastrointest Surg 14(6):958–964PubMedCrossRef
31.
go back to reference Tanimura S, Higashino M, Fukunaga Y, Takemura M, Tanaka Y, Fujiwara Y et al (2008) Laparoscopic gastrectomy for gastric cancer: experience with more than 600 cases. Surg Endosc 22(5):1161–1164PubMedCrossRef Tanimura S, Higashino M, Fukunaga Y, Takemura M, Tanaka Y, Fujiwara Y et al (2008) Laparoscopic gastrectomy for gastric cancer: experience with more than 600 cases. Surg Endosc 22(5):1161–1164PubMedCrossRef
32.
go back to reference Kim MC (2005) Learning curve of laparoscopy-assisted distal gastrectomy with systemic lymphadenectomy for early gastric cancer. World J Gastroenterol 11:7508PubMed Kim MC (2005) Learning curve of laparoscopy-assisted distal gastrectomy with systemic lymphadenectomy for early gastric cancer. World J Gastroenterol 11:7508PubMed
33.
go back to reference Song KY, Kim SN, Park CH (2008) Laparoscopy-assisted distal gastrectomy with D2 lymph node dissection for gastric cancer: technical and oncologic aspects. Surg Endosc 22(3):655–659PubMedCrossRef Song KY, Kim SN, Park CH (2008) Laparoscopy-assisted distal gastrectomy with D2 lymph node dissection for gastric cancer: technical and oncologic aspects. Surg Endosc 22(3):655–659PubMedCrossRef
34.
go back to reference Tekkis PP, Senagore AJ, Delaney CP, Fazio VW (2005) Evaluation of the learning curve in laparoscopic colorectal surgery: comparison of right-sided and left-sided resections. Ann Surg 242(1):83–91PubMedCrossRef Tekkis PP, Senagore AJ, Delaney CP, Fazio VW (2005) Evaluation of the learning curve in laparoscopic colorectal surgery: comparison of right-sided and left-sided resections. Ann Surg 242(1):83–91PubMedCrossRef
35.
go back to reference Birkmeyer JD, Sun Y, Goldfaden A, Birkmeyer NJ, Stukel TA (2006) Volume and process of care in high-risk cancer surgery. Cancer 106:2476–2481PubMedCrossRef Birkmeyer JD, Sun Y, Goldfaden A, Birkmeyer NJ, Stukel TA (2006) Volume and process of care in high-risk cancer surgery. Cancer 106:2476–2481PubMedCrossRef
36.
go back to reference Sarela AI (2009) Entirely laparoscopic radical gastrectomy for adenocarcinoma: lymph node yield and resection margins. Surg Endosc 23(1):153–160PubMedCrossRef Sarela AI (2009) Entirely laparoscopic radical gastrectomy for adenocarcinoma: lymph node yield and resection margins. Surg Endosc 23(1):153–160PubMedCrossRef
37.
go back to reference Strong VE, Devaud N, Allen PJ, Gonen M, Brennan MF, Coit D (2009) Laparoscopic versus open subtotal gastrectomy for adenocarcinoma: a case–control study. Ann Surg Oncol 16(6):1507–1513PubMedCrossRef Strong VE, Devaud N, Allen PJ, Gonen M, Brennan MF, Coit D (2009) Laparoscopic versus open subtotal gastrectomy for adenocarcinoma: a case–control study. Ann Surg Oncol 16(6):1507–1513PubMedCrossRef
38.
go back to reference Grantcharov TP, Kehlet H (2010) Laparoscopic gastric surgery in an enhanced recovery programme. Br J Surg 97:1547–1551PubMedCrossRef Grantcharov TP, Kehlet H (2010) Laparoscopic gastric surgery in an enhanced recovery programme. Br J Surg 97:1547–1551PubMedCrossRef
39.
go back to reference Strong VE, Allen PJ, Brennan MF (2009) Coit D. Ann Surg Oncol 16(9):2665–2666 (author reply 2667)CrossRef Strong VE, Allen PJ, Brennan MF (2009) Coit D. Ann Surg Oncol 16(9):2665–2666 (author reply 2667)CrossRef
Metadata
Title
Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer: a case–control study
Authors
Marco Scatizzi
Katrin C. Kröning
Elisa Lenzi
Luca Moraldi
Stefano Cantafio
Francesco Feroci
Publication date
01-03-2011
Publisher
Springer Milan
Published in
Updates in Surgery / Issue 1/2011
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI
https://doi.org/10.1007/s13304-011-0043-1

Other articles of this Issue 1/2011

Updates in Surgery 1/2011 Go to the issue