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Diabetes Therapy
Published in: Diabetes Therapy 8/2020

Open Access 01-08-2020 | Insulins | Review

Treatment Options for MODY Patients: A Systematic Review of Literature

Authors: Maurizio Delvecchio, Carmela Pastore, Paola Giordano

Published in: Diabetes Therapy | Issue 8/2020

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Abstract

Maturity-onset diabetes of the young (MODY) is an unusual form of diabetes with specific features that distinguish it from type 1 and type 2 diabetes. There are 14 known subtypes of MODY, and mutations in three genes (HNF1A, HNF4A, GCK) account for about 95% of all MODY cases. Diagnosis usually occurs before the age of 25 years, although less frequent forms may occur more often—but not necessarily—later in life. The molecular diagnosis may tailor the choice of the most appropriate treatment, with the aim to optimize blood glucose control, reduce the risk of hypoglycemic events and long-term complications, and enable proper genetic counseling. Treatment is usually unnecessary for patients with mutations in the GCK gene, while oral hypoglycemic agents (generally sulphonylureas) are recommended for patients with mutations in the HNF4A and HNF1A genes. More recent data show that other glucose-lowering agents can be effective in the latter patients, and additional and alternative therapies have been proposed. Proper management guidelines during pregnancy have been developed for carriers of GCK gene mutations, but such guidelines are still a subject of debate in other cases, although some recommendations are available. The other subtypes of MODY are even more rare, and very little data are available in the literature. In this review we summarize the most pertinent findings and recommendations on the treatment of patients with the different subtypes of MODY. Our aim is to provide the reader with an easy-to-read update that can be used to drive the clinician’s therapeutical approach to these patients after the molecular diagnosis.
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Metadata
Title
Treatment Options for MODY Patients: A Systematic Review of Literature
Authors
Maurizio Delvecchio
Carmela Pastore
Paola Giordano
Publication date
01-08-2020
Publisher
Springer Healthcare
Published in
Diabetes Therapy / Issue 8/2020
Print ISSN: 1869-6953
Electronic ISSN: 1869-6961
DOI
https://doi.org/10.1007/s13300-020-00864-4

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