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Diabetes Therapy
Published in: Diabetes Therapy 5/2017

Open Access 01-10-2017 | Original Research

Effects of Vildagliptin Add-on Insulin Therapy on Nocturnal Glycemic Variations in Uncontrolled Type 2 Diabetes

Authors: Feng-fei Li, Yun Shen, Rui Sun, Dan-feng Zhang, Xing Jin, Xiao-fang Zhai, Mao-yuan Chen, Xiao-fei Su, Jin-dan Wu, Lei Ye, Jian-hua Ma

Published in: Diabetes Therapy | Issue 5/2017

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Abstract

Introduction

To investigate whether vildagliptin add-on insulin therapy improves glycemic variations in patients with uncontrolled type 2 diabetes (T2D) compared to patients with placebo therapy.

Methods

This was a 24-week, single-center, double-blind, placebo-controlled trial. Inadequately controlled T2D patients treated with insulin therapy were recruited between June 2012 and April 2013. The trial included a 2-week screening period and a 24-week randomized period. Subjects were randomly assigned to a vildagliptin add-on insulin therapy group (n = 17) or a matched placebo group (n = 16). Scheduled visits occurred at weeks 4, 8, 12, 16, 20, and 24. Continuous glucose monitoring (CGM) was performed before and at the endpoint of the study.

Results

A total of 33 subjects were admitted, with 1 patient withdrawing from the placebo group. After 24 weeks of therapy, HbA1c values were significantly reduced at the endpoint in the vildagliptin add-on group. CGM data showed that patients with vildagliptin add-on therapy had a significantly lower 24-h mean glucose concentration and mean amplitude of glycemic excursion (MAGE). At the endpoint of the study, patients in the vildagliptin add-on group had a significantly lower MAGE and standard deviation compared to the control patients during the nocturnal period (0000–0600). A severe hypoglycemic episode was not observed in either group.

Conclusion

Vildagliptin add-on therapy to insulin has the ability to improve glycemic variations, especially during the nocturnal time period, in patients with uncontrolled T2D.
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Metadata
Title
Effects of Vildagliptin Add-on Insulin Therapy on Nocturnal Glycemic Variations in Uncontrolled Type 2 Diabetes
Authors
Feng-fei Li
Yun Shen
Rui Sun
Dan-feng Zhang
Xing Jin
Xiao-fang Zhai
Mao-yuan Chen
Xiao-fei Su
Jin-dan Wu
Lei Ye
Jian-hua Ma
Publication date
01-10-2017
Publisher
Springer Healthcare
Published in
Diabetes Therapy / Issue 5/2017
Print ISSN: 1869-6953
Electronic ISSN: 1869-6961
DOI
https://doi.org/10.1007/s13300-017-0303-2

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