Skip to main content
Top
Published in: Diabetes Therapy 1/2016

Open Access 01-03-2016 | Case Report

Faulty Injection Technique: A Preventable But Often Overlooked Factor in Insulin Allergy

Authors: Partha Pratim Chakraborty, Sugata Narayan Biswas, Shinjan Patra

Published in: Diabetes Therapy | Issue 1/2016

Login to get access

Abstract

Insulin hypersensitivity—a rare occurrence with currently available insulin preparations—may have varied manifestations, ranging from a local injection site allergy to severe generalized anaphylactic reactions. While various additives included in commercial insulin preparations and insulin peptides themselves remain the primary allergens responsible, faulty injection technique may at times potentiate the development of insulin allergy. Management of insulin allergy is complex, potentially dangerous at times, and can be challenging for the treating physician. We report a case of insulin allergy due to intradermal insulin injections which was cured by adopting a proper injection technique.
Literature
1.
go back to reference Jacquier J, Chik CL, Senior PA. A practical, clinical approach to the assessment and management of suspected insulin allergy. Diabet Med. 2013;30:977–85.CrossRefPubMed Jacquier J, Chik CL, Senior PA. A practical, clinical approach to the assessment and management of suspected insulin allergy. Diabet Med. 2013;30:977–85.CrossRefPubMed
2.
go back to reference Belhekar MN, Pai S, Tayade P, Dalwadi P, Munshi R, Varthakavi P. A case of hypersensitivity to soluble and isophane insulins but not to insulin glargine. Indian J Pharmacol. 2015;47(2):227–9.CrossRefPubMedPubMedCentral Belhekar MN, Pai S, Tayade P, Dalwadi P, Munshi R, Varthakavi P. A case of hypersensitivity to soluble and isophane insulins but not to insulin glargine. Indian J Pharmacol. 2015;47(2):227–9.CrossRefPubMedPubMedCentral
3.
go back to reference Rojas J, et al. Successful management of insulin allergy and autoimmune polyendocrine syndrome type 4 with desensitization therapy and glucocorticoid treatment: a case report and review of the literature. Case Reports Immunol. 2014;2014:394754.CrossRefPubMedPubMedCentral Rojas J, et al. Successful management of insulin allergy and autoimmune polyendocrine syndrome type 4 with desensitization therapy and glucocorticoid treatment: a case report and review of the literature. Case Reports Immunol. 2014;2014:394754.CrossRefPubMedPubMedCentral
5.
go back to reference Fujishiro M, et al. A case of insulin allergy successfully managed using multihexamer-forming insulin degludec combined with liraglutide. Diabet Med. 2016. doi:10.1111/dme.12998 (Epub ahead of print). Fujishiro M, et al. A case of insulin allergy successfully managed using multihexamer-forming insulin degludec combined with liraglutide. Diabet Med. 2016. doi:10.​1111/​dme.​12998 (Epub ahead of print).
6.
go back to reference Cumberbatch M, Dearman RJ, Griffiths CE, Kimber I. Epidermal langerhans cell migration and sensitisation to chemical allergens. APMIS. 2003;111(7–8):797–804.CrossRefPubMed Cumberbatch M, Dearman RJ, Griffiths CE, Kimber I. Epidermal langerhans cell migration and sensitisation to chemical allergens. APMIS. 2003;111(7–8):797–804.CrossRefPubMed
7.
go back to reference Sanyal T, Ghosh S, Chowdhury S, Mukherjee S. Can a faulty injection technique lead to a localized insulin allergy? Indian J Endocrinol Metab. 2013;17:S358–9.CrossRefPubMedPubMedCentral Sanyal T, Ghosh S, Chowdhury S, Mukherjee S. Can a faulty injection technique lead to a localized insulin allergy? Indian J Endocrinol Metab. 2013;17:S358–9.CrossRefPubMedPubMedCentral
Metadata
Title
Faulty Injection Technique: A Preventable But Often Overlooked Factor in Insulin Allergy
Authors
Partha Pratim Chakraborty
Sugata Narayan Biswas
Shinjan Patra
Publication date
01-03-2016
Publisher
Springer Healthcare
Published in
Diabetes Therapy / Issue 1/2016
Print ISSN: 1869-6953
Electronic ISSN: 1869-6961
DOI
https://doi.org/10.1007/s13300-016-0151-5

Other articles of this Issue 1/2016

Diabetes Therapy 1/2016 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.