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01-11-2016 | Review

A critical overview of long non-coding RNA in glioma etiology 2016: an update

Authors: Yuan-Feng Gao, Zhi-Bin Wang, Tao Zhu, Chen-Xue Mao, Xiao-Yuan Mao, Ling Li, Ji-Ye Yin, Hong-Hao Zhou, Zhao-Qian Liu

Published in: Tumor Biology | Issue 11/2016

Abstract

With the development of whole genome and transcriptome sequencing technologies, a growing body of long non-coding RNAs (lncRNAs) has been identified and is receiving increasing attention. LncRNAs are non-protein encoding transcripts whose functions are crucial for advancing our comprehensive understanding of biological processes in human health and diseases, specifically glioma. It has been established that lncRNAs are differently expressed in the central nervous system and may play a vital role in glioma. As of June 2016, 20 lncRNAs have been identified that may play a role in glioma pathogenesis. Investigation into the role of lncRNAs in glioma may help to identify potential biomarkers which can improve the diagnosis and treatment of glioma. In this paper, we review current understanding of the function of lncRNAs in glioma initiation and progression.

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Title: A critical overview of long non-coding RNA in glioma etiology 2016: an update
Authors: Yuan-Feng Gao
Zhi-Bin Wang
Tao Zhu
Chen-Xue Mao
Xiao-Yuan Mao
Ling Li
Ji-Ye Yin
Hong-Hao Zhou
Zhao-Qian Liu
Publication date: 01-11-2016
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 11/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-016-5307-4

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