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Tumor Biology
Published in: Tumor Biology 5/2016

01-05-2016 | Review

Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers

Authors: Shiwei He, Yancheng Zhong, Cijun Shuai, Dan Gao, Pingpin Wei, Guiyuan Li, Shuping Peng

Published in: Tumor Biology | Issue 5/2016

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Abstract

Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a membrane protein primarily located in the nuclear membrane and cell membrane. Several groups reported that NGX6 gene was down-regulated in nasopharyngeal carcinoma (NPC), gastric cancer, lung cancer, liver cancer, and colorectal cancer and even less in the carcinomas with metastasis. Current studies have demonstrated that NGX6 possesses various biological functions, such as regulating protein expression of related genes, involving cell signal transduction pathways, negatively controlling cell cycle progression, inhibiting angiogenesis, and increasing the sensitivity of patients to anti-cancer drugs. Some factors regulating the expression level of NGX6 gene also have been studied. The methylation of promoter of NGX6 and histone H3K9 negatively regulates its expression, similar to the function of transcription factor special protein-1 (Sp1). However, the regulatory factor early growth response gene 1 (Egr-1) is provided with positive regulation function. This review will summarize the progress of those studies on NGX6 and elucidate the potential application of NGX6 for some malignant diseases.
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Metadata
Title
Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers
Authors
Shiwei He
Yancheng Zhong
Cijun Shuai
Dan Gao
Pingpin Wei
Guiyuan Li
Shuping Peng
Publication date
01-05-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 5/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-4966-5

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