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Tumor Biology
Published in: Tumor Biology 4/2016

01-04-2016 | Review

The role of oxidative stress on breast cancer development and therapy

Authors: Fabio Hecht, Carolina F. Pessoa, Luciana B. Gentile, Doris Rosenthal, Denise P. Carvalho, Rodrigo S. Fortunato

Published in: Tumor Biology | Issue 4/2016

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Abstract

Reactive oxygen species (ROS) are produced by both enzymatic and non-enzymatic systems within eukaryotic cells and play important roles in cellular physiology and pathophysiology. Although physiological concentrations are crucial for ensuring cell survival, ROS overproduction is detrimental to cells, and considered key-factors for the development of several diseases, such as neurodegenerative diseases, cardiovascular disorders, and cancer. Cancer cells are usually submitted to higher ROS levels that further stimulate malignant phenotype through stimulus to sustained proliferation, death evasion, angiogenesis, invasiveness, and metastasis. The role of ROS on breast cancer etiology and progression is being progressively elucidated. However, less attention has been given to the development of redox system-targeted strategies for breast cancer therapy. In this review, we address the basic mechanisms of ROS production and scavenging in breast tumor cells, and the emerging possibilities of breast cancer therapies targeting ROS homeostasis.
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Metadata
Title
The role of oxidative stress on breast cancer development and therapy
Authors
Fabio Hecht
Carolina F. Pessoa
Luciana B. Gentile
Doris Rosenthal
Denise P. Carvalho
Rodrigo S. Fortunato
Publication date
01-04-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 4/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-4873-9

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