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01-05-2016 | Original Article

Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk

Authors: Kuo-Jung Su, Chuan-Chen Ho, Chiao-Wen Lin, Mu-Kuan Chen, Shih-Chi Su, Yung-Luen Yu, Shun-Fa Yang

Published in: Tumor Biology | Issue 5/2016

Abstract

In humans, fucosyltransferase-2 (FUT2) plays an important role in α1,2- linkage of fucose and participates in complex cellular processes such as fertilization, embryogenesis, and immune responses. However, little information is available concerning the FUT2 expression in tumorigenesis. The aim of this work was to investigate the combined effect of FUT2 gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinic pathological characteristics of oral cancer. Four SNPs of the FUT2 gene (rs281377, rs1047781, rs601338, and rs602662) from 1200 non-cancer controls and 700 oral squamous cell carcinoma (OSCC) patients were analyzed by real-time polymerase chain reaction (PCR). The samples were further analyzed to clarify the associations between these gene polymorphisms and the risk of OSCC, and the impact of these SNPs on the susceptibility and clinic pathological characteristics of OSCC. After adjusting for other covariant, we observed that betel quid chewing among 1255 smokers who carrying at least one C genotype (TC and CC) at rs281377 and least one T genotype (TA and TT) at rs1047781 were exhibited synergistic effects of environmental factors (betel quid and cigarette use) on the susceptibility of oral cancer. Taken together, our results support gene–environment interactions of FUT2 polymorphisms with smoking and betel quid chewing habits possibly altering oral cancer susceptibility. Furthermore, to our knowledge, this is the first study of association between FUT2 gene variants and OSCC risk.

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Title: Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk
Authors: Kuo-Jung Su
Chuan-Chen Ho
Chiao-Wen Lin
Mu-Kuan Chen
Shih-Chi Su
Yung-Luen Yu
Shun-Fa Yang
Publication date: 01-05-2016
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 5/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-4367-1

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