Published in:
01-10-2014 | Review
Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview
Author:
Samapika Routray
Published in:
Tumor Biology
|
Issue 10/2014
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Abstract
Caveolin-1 plays an important role in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis. Increased expression of caveolin-1 in an array of tumors has confirmed its value in prognosis. It has been established that oxidative stress is the main cause for loss of stromal caveolin-1 via autophagy in the tumor microenvironment. In this overview, we attempt to abridge the relationship between caveolin-1 and oral squamous cell carcinoma, taking all the established theories into consideration.