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Tumor Biology
Published in: Tumor Biology 2/2011

01-04-2011 | Research Article

Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV)

Authors: José Vieira de Spíndula-Filho, Aparecido Divino da Cruz, Angélica Ferreira Oton-Leite, Aline Carvalho Batista, Cláudio Rodrigues Leles, Rita de Cássia Gonçalves Alencar, Vera Aparecida Saddi, Elismauro Francisco Mendonça

Published in: Tumor Biology | Issue 2/2011

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Abstract

Human papillomavirus (HPV) has been cited as a possible initiating agent in the pathogenesis of oral cancer. However, the literature tends to be both controversial and inconclusive about the prevalence of HPV and its potential for proliferation in oral squamous cell carcinoma (SCC). The aim of this study was to investigate the cellular proliferation and the presence of HPV in SCC and verrucous carcinoma (VC). Forty-seven samples of SCC were selected and divided into three groups: 39 SCC, 8 VC, and 9 of normal mucosa (control-CT). Quantitative analyses of all groups showed a greater expression of PCNA, followed by Ki-67 and cyclin B1. A significant difference was observed in cyclin B1 expression in the SCC group compared with VC. PCNA, Ki-67, and cyclin B1 were statistically significant when comparing the SCC and CT groups. However, when SCC and VC were compared, there was no difference in Ki-67 expression. Our results showed that only cyclin B1 had an association with histological grade, and that poorly differentiated tumors presented a higher expression of cyclin B1. Therefore, considerable differences in the cellular proliferation between SCC and VC were observed, and no correlation with HPV was established, since all samples were negative for HPV.
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Metadata
Title
Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV)
Authors
José Vieira de Spíndula-Filho
Aparecido Divino da Cruz
Angélica Ferreira Oton-Leite
Aline Carvalho Batista
Cláudio Rodrigues Leles
Rita de Cássia Gonçalves Alencar
Vera Aparecida Saddi
Elismauro Francisco Mendonça
Publication date
01-04-2011
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 2/2011
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-010-0135-4

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