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Published in: Insights into Imaging 4/2016

Open Access 01-08-2016 | Pictorial Review

The pterygopalatine fossa: imaging anatomy, communications, and pathology revisited

Authors: Sonam Tashi, Bela S. Purohit, Minerva Becker, Pravin Mundada

Published in: Insights into Imaging | Issue 4/2016

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Abstract

The pterygopalatine fossa (PPF) is a small, clinically inaccessible, fat-filled space located in the deep face that serves as a major neurovascular crossroad between the oral cavity, nasal cavity, nasopharynx, orbit, masticator space, and the middle cranial fossa. Due to its inherent complex location and connections, it can potentially act as a natural conduit for the spread of inflammatory and neoplastic diseases across the various deep spaces in the head and neck. This review aims to acquaint the reader with the imaging anatomy of the PPF, its important communications, and to identify some major pathological conditions that can involve the PPF, especially in conditions where its involvement can have serious diagnostic and therapeutic implications, such as in perineural tumour spread.

Teaching points

The PPF is a small neurovascular junction in the deep face with important to-and-fro connections.
Awareness of anatomy of the PPF and its communications helps to simplify imaging of its pathology.
Perineural tumour spread is clinically the most important pathology in this region.
Literature
1.
go back to reference Curtin HD, Williams R (1985) Computed tomographic anatomy of the pterygopalatine fossa. Radiographics 5:429–440CrossRef Curtin HD, Williams R (1985) Computed tomographic anatomy of the pterygopalatine fossa. Radiographics 5:429–440CrossRef
2.
go back to reference Daniels DL, Mark LP, Ulmer JL, Mafee MF, McDaniel J, Shah NC et al (1998) Osseous anatomy of the pterygopalatine fossa. AJNR Am J Neuroradiol 19:1423–1432PubMed Daniels DL, Mark LP, Ulmer JL, Mafee MF, McDaniel J, Shah NC et al (1998) Osseous anatomy of the pterygopalatine fossa. AJNR Am J Neuroradiol 19:1423–1432PubMed
3.
go back to reference Kim HS, Kim DI, Chung IH (1996) High-resolution CT of the pterygopalatine fossa and its communications. Neuroradiology 38:S120–126CrossRefPubMed Kim HS, Kim DI, Chung IH (1996) High-resolution CT of the pterygopalatine fossa and its communications. Neuroradiology 38:S120–126CrossRefPubMed
4.
go back to reference Erdogan N, Erdogan U, Baykara M (2003) CT anatomy of pterygopalatine fossa and its communications: a pictorial review. Comput Med Imaging Graph 27:481–487CrossRefPubMed Erdogan N, Erdogan U, Baykara M (2003) CT anatomy of pterygopalatine fossa and its communications: a pictorial review. Comput Med Imaging Graph 27:481–487CrossRefPubMed
5.
go back to reference Tomura N, Hirano H, Kato K, Takahashi S, Sashi R, Tate E et al (1999) Comparison of MR imaging with CT in depiction of tumour extension into the pterygopalatine fossa. Clin Radiol 54:361–366CrossRefPubMed Tomura N, Hirano H, Kato K, Takahashi S, Sashi R, Tate E et al (1999) Comparison of MR imaging with CT in depiction of tumour extension into the pterygopalatine fossa. Clin Radiol 54:361–366CrossRefPubMed
6.
go back to reference Moonis G, Cunane MB, Emerick K, Curtin H (2012) Patterns of perineural tumor spread in head and neck cancer. Magn Reson Imaging Clin N Am 20:435–446CrossRefPubMed Moonis G, Cunane MB, Emerick K, Curtin H (2012) Patterns of perineural tumor spread in head and neck cancer. Magn Reson Imaging Clin N Am 20:435–446CrossRefPubMed
7.
go back to reference Chan LL, Chong J, Gillenwater AM, Ginsberg LE (2000) The pterygopalatine fossa: postoperative MR imaging appearance. Am J Neuroradiol 2:1315–1319 Chan LL, Chong J, Gillenwater AM, Ginsberg LE (2000) The pterygopalatine fossa: postoperative MR imaging appearance. Am J Neuroradiol 2:1315–1319
9.
go back to reference Yousem DM, Gad K, Tufano RP (2006) Resectability issues with head and neck cancer. AJNR Am J Neuroradiol 27:2024–2036PubMed Yousem DM, Gad K, Tufano RP (2006) Resectability issues with head and neck cancer. AJNR Am J Neuroradiol 27:2024–2036PubMed
10.
go back to reference Maroldi R, Nicolai P (eds) (2004) Imaging in treatment planning for sinonasal diseases. Springer Verlag, New York, pp 107–158 Maroldi R, Nicolai P (eds) (2004) Imaging in treatment planning for sinonasal diseases. Springer Verlag, New York, pp 107–158
11.
go back to reference Sennes LU, Butugan O, Sanchez TG, Bento RF, Tsuji DH (2003) Juvenile nasopharyngeal angiofibroma: the routes of invasion. Rhinology 41:235–240PubMed Sennes LU, Butugan O, Sanchez TG, Bento RF, Tsuji DH (2003) Juvenile nasopharyngeal angiofibroma: the routes of invasion. Rhinology 41:235–240PubMed
12.
go back to reference Eloy P, Watelet JB, Hatert AS, de Wispelaere J, Bertrand B (2007) Endonasal endoscopic resection of juvenile nasopharyngeal angiofibroma. Rhinology 45:24–30PubMed Eloy P, Watelet JB, Hatert AS, de Wispelaere J, Bertrand B (2007) Endonasal endoscopic resection of juvenile nasopharyngeal angiofibroma. Rhinology 45:24–30PubMed
13.
go back to reference Nicolai P, Schreiber A, Villaret AB (2012) Juvenile angiofibroma: evolution of management. Int J Pediatr 2012:412545CrossRefPubMed Nicolai P, Schreiber A, Villaret AB (2012) Juvenile angiofibroma: evolution of management. Int J Pediatr 2012:412545CrossRefPubMed
14.
go back to reference Chong VF, Fan YF (1997) Pterygopalatine fossa and maxillary nerve infiltration in nasopharyngeal carcinoma. Head Neck 19:121–125CrossRefPubMed Chong VF, Fan YF (1997) Pterygopalatine fossa and maxillary nerve infiltration in nasopharyngeal carcinoma. Head Neck 19:121–125CrossRefPubMed
15.
go back to reference Chong VF, Fan YF, Khoo JB, Lim TA (1995) Comparing computed tomographic and magnetic resonance imaging visualisation of the pterygopalatine fossa in nasopharyngeal carcinoma. Ann Acad Med Singapore 24:436–441PubMed Chong VF, Fan YF, Khoo JB, Lim TA (1995) Comparing computed tomographic and magnetic resonance imaging visualisation of the pterygopalatine fossa in nasopharyngeal carcinoma. Ann Acad Med Singapore 24:436–441PubMed
16.
go back to reference Luo CB, Teng MM, Chen SS, Lirng JF, Guo WY, Chang T (1998) Orbital invasion in nasopharyngeal carcinoma: evaluation with computed tomography and magnetic resonance imaging. Zhonghua Yi Xue Za Zhi 61:382–388PubMed Luo CB, Teng MM, Chen SS, Lirng JF, Guo WY, Chang T (1998) Orbital invasion in nasopharyngeal carcinoma: evaluation with computed tomography and magnetic resonance imaging. Zhonghua Yi Xue Za Zhi 61:382–388PubMed
17.
go back to reference Razek AAKA, King A (2012) MRI and CT of nasopharyngeal carcinoma. AJR Am J Roentgenol 198:11–8CrossRef Razek AAKA, King A (2012) MRI and CT of nasopharyngeal carcinoma. AJR Am J Roentgenol 198:11–8CrossRef
18.
go back to reference Heng DMK, Wee J, Fong KW, Lian LG, Sethi VK, Chua ET et al (1999) Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma. Cancer 15:1912–1920CrossRef Heng DMK, Wee J, Fong KW, Lian LG, Sethi VK, Chua ET et al (1999) Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma. Cancer 15:1912–1920CrossRef
19.
go back to reference Au JSK, Law CK, Foo W, Lau WH (2003) In-depth evaluation of the AJCC/UICC 1997 staging system of nasopharyngeal carcinoma: prognostic homogeneity and proposed refinement. Int J Radiat Oncol Biol Phys 56:413–426CrossRefPubMed Au JSK, Law CK, Foo W, Lau WH (2003) In-depth evaluation of the AJCC/UICC 1997 staging system of nasopharyngeal carcinoma: prognostic homogeneity and proposed refinement. Int J Radiat Oncol Biol Phys 56:413–426CrossRefPubMed
20.
go back to reference Tang LL, Li WF, Chen L, Sun Y, Chen Y, Liu LZ et al (2010) Prognostic value and staging categories of anatomic masticator space involvement in nasopharyngeal carcinoma: a study of 924 cases with MR imaging. Radiology 257:151–157CrossRefPubMed Tang LL, Li WF, Chen L, Sun Y, Chen Y, Liu LZ et al (2010) Prognostic value and staging categories of anatomic masticator space involvement in nasopharyngeal carcinoma: a study of 924 cases with MR imaging. Radiology 257:151–157CrossRefPubMed
21.
go back to reference Liu L, Liang S, Li L, Mao Y, Tang L, Tian L et al (2009) Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma. Cancer 115:1995–2003CrossRefPubMed Liu L, Liang S, Li L, Mao Y, Tang L, Tian L et al (2009) Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma. Cancer 115:1995–2003CrossRefPubMed
23.
go back to reference Freling NJM, Merks JHM, Saeed P, Balm AJM, Bras J, Pieters BR et al (2010) Imaging findings in craniofacial childhood Rhabdomyosarcoma. Pediatr Radiol 40:1723–1738CrossRefPubMedPubMedCentral Freling NJM, Merks JHM, Saeed P, Balm AJM, Bras J, Pieters BR et al (2010) Imaging findings in craniofacial childhood Rhabdomyosarcoma. Pediatr Radiol 40:1723–1738CrossRefPubMedPubMedCentral
24.
go back to reference Yu Q, Wang P, Shi H, Luo J, Sun D (1998) The lesions of the pterygopalatine and infratemporal spaces: computed tomography evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:742–51CrossRefPubMed Yu Q, Wang P, Shi H, Luo J, Sun D (1998) The lesions of the pterygopalatine and infratemporal spaces: computed tomography evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:742–51CrossRefPubMed
25.
go back to reference Becker M, Kohler R, Vargas MI, Viallon M, Delavelle J (2008) Pathology of the trigeminal nerve. Neuroimaging Clin N Am 18:283–307CrossRefPubMed Becker M, Kohler R, Vargas MI, Viallon M, Delavelle J (2008) Pathology of the trigeminal nerve. Neuroimaging Clin N Am 18:283–307CrossRefPubMed
26.
go back to reference Minard-Colin V, Kolb F, Saint-Rose C, Fayard F, Janot F, Rey A et al (2013) Impact of extensive surgery in multidisciplinary approach of pterygopalatine/infratemporal fossa soft tissue sarcoma. Pediatr Blood Cancer 60:928–934CrossRefPubMed Minard-Colin V, Kolb F, Saint-Rose C, Fayard F, Janot F, Rey A et al (2013) Impact of extensive surgery in multidisciplinary approach of pterygopalatine/infratemporal fossa soft tissue sarcoma. Pediatr Blood Cancer 60:928–934CrossRefPubMed
27.
go back to reference Ginsberg LE, DeMonte F (1998) Imaging of perineural tumor spread from palatal carcinoma. AJNR Am J Neuroradiol 19:1417–1422PubMed Ginsberg LE, DeMonte F (1998) Imaging of perineural tumor spread from palatal carcinoma. AJNR Am J Neuroradiol 19:1417–1422PubMed
28.
go back to reference Sobin LH, Gospodarowicz MK, Wittekind C (2009) TNM classification of malignant tumours, 7th edn. Wiley-Blackwell, Washington, DC Sobin LH, Gospodarowicz MK, Wittekind C (2009) TNM classification of malignant tumours, 7th edn. Wiley-Blackwell, Washington, DC
30.
go back to reference Trotta BM, Pease CS, Rasamny JJ, Raghavan P, Mukherjee S (2011) Oral cavity and oropharyngeal squamous cell cancer: key imaging findings for staging and treatment planning. Radiographics 31:339–54CrossRefPubMed Trotta BM, Pease CS, Rasamny JJ, Raghavan P, Mukherjee S (2011) Oral cavity and oropharyngeal squamous cell cancer: key imaging findings for staging and treatment planning. Radiographics 31:339–54CrossRefPubMed
31.
go back to reference Gil Z, Carlson DL, Gupta A, Lee N, Hoppe B, Shah JP et al (2009) Patterns and incidence of neural invasion in patients with cancers of the paranasal sinuses. Arch Otolaryngol Head Neck Surg 135:173–179CrossRefPubMed Gil Z, Carlson DL, Gupta A, Lee N, Hoppe B, Shah JP et al (2009) Patterns and incidence of neural invasion in patients with cancers of the paranasal sinuses. Arch Otolaryngol Head Neck Surg 135:173–179CrossRefPubMed
32.
go back to reference Kazi M, Awan S, Junaid M, Qadeer S, Hassan NH (2013) Management of sinonasal tumors: prognostic factors and outcomes: a 10 years experience at a tertiary care hospital. Indian J Otolaryngol Head Neck Surg 65:155–159CrossRefPubMedPubMedCentral Kazi M, Awan S, Junaid M, Qadeer S, Hassan NH (2013) Management of sinonasal tumors: prognostic factors and outcomes: a 10 years experience at a tertiary care hospital. Indian J Otolaryngol Head Neck Surg 65:155–159CrossRefPubMedPubMedCentral
33.
go back to reference Carter JB, Johnson MM, Chua TL, Karia PS, Schmults CD (2013) Outcomes of primary cutaneous squamous cell carcinoma with perineural invasion. JAMA Dermatol 149:35–41CrossRefPubMed Carter JB, Johnson MM, Chua TL, Karia PS, Schmults CD (2013) Outcomes of primary cutaneous squamous cell carcinoma with perineural invasion. JAMA Dermatol 149:35–41CrossRefPubMed
35.
go back to reference Goyal P, Leung MK, Hwang PH (2009) Endoscopic approach to the infratemporal fossa for treatment of invasive fungal sinusitis. Am J Rhinol Allergy 23:100–104CrossRefPubMed Goyal P, Leung MK, Hwang PH (2009) Endoscopic approach to the infratemporal fossa for treatment of invasive fungal sinusitis. Am J Rhinol Allergy 23:100–104CrossRefPubMed
36.
go back to reference Kim TH, Jang HU, Jung YY, Kim JS (2012) Granulomatous invasive fungal rhinosinusitis extending into the pterygopalatine fossa and orbital floor. Med Mycol Case Rep 1:107–111CrossRefPubMedPubMedCentral Kim TH, Jang HU, Jung YY, Kim JS (2012) Granulomatous invasive fungal rhinosinusitis extending into the pterygopalatine fossa and orbital floor. Med Mycol Case Rep 1:107–111CrossRefPubMedPubMedCentral
37.
go back to reference Hosseini SM, Borghei P (2005) Rhinocerebral mucormycosis: pathways of spread. Eur Arch Otorhinolaryngol 262:932–938CrossRefPubMed Hosseini SM, Borghei P (2005) Rhinocerebral mucormycosis: pathways of spread. Eur Arch Otorhinolaryngol 262:932–938CrossRefPubMed
38.
go back to reference Maschio M, Mengarelli A, Girmenia C, Vidire A, Kayal R, Gallo MT et al (2012) Trigeminal neuralgia as unusual isolated symptom of fungal paranasal sinusitis in patients with haematological malignancies. Neurol Sci 33:647–652CrossRefPubMed Maschio M, Mengarelli A, Girmenia C, Vidire A, Kayal R, Gallo MT et al (2012) Trigeminal neuralgia as unusual isolated symptom of fungal paranasal sinusitis in patients with haematological malignancies. Neurol Sci 33:647–652CrossRefPubMed
39.
go back to reference Hostler HB, Okumoto M (2012) Infections of the eye and orbit. In: Schlossberg D (ed) Infections of the head and neck. Springer Verlag, Berlin, pp 14–42 Hostler HB, Okumoto M (2012) Infections of the eye and orbit. In: Schlossberg D (ed) Infections of the head and neck. Springer Verlag, Berlin, pp 14–42
40.
go back to reference Lale AM, Jani PJ, Ellis PD (1998) An unusual complication of chemotherapy: an abscess in the pterygopalatine fossa. J Laryngol Otol 112:296–297PubMed Lale AM, Jani PJ, Ellis PD (1998) An unusual complication of chemotherapy: an abscess in the pterygopalatine fossa. J Laryngol Otol 112:296–297PubMed
41.
go back to reference Park SB, Lee JH, Weon YC (2009) Imaging findings of head and neck inflammatory pseudotumor. AJR Am J Roentgenol 193:1180–1186CrossRefPubMed Park SB, Lee JH, Weon YC (2009) Imaging findings of head and neck inflammatory pseudotumor. AJR Am J Roentgenol 193:1180–1186CrossRefPubMed
42.
go back to reference Becker M, Masterson K, Delavelle J, Viallon M, Vargas MI, Becker CD (2010) Imaging of the optic nerve. Eur J Radiol 74(2):299–313CrossRefPubMed Becker M, Masterson K, Delavelle J, Viallon M, Vargas MI, Becker CD (2010) Imaging of the optic nerve. Eur J Radiol 74(2):299–313CrossRefPubMed
43.
go back to reference Lee EJ, Jung SL, Kim BS, Ahn KJ, Kim YJ, Jung AK et al (2005) MR imaging of orbital inflammatory pseudotumors with extraorbital extension. Korean J Radiol 6:82–88CrossRefPubMedPubMedCentral Lee EJ, Jung SL, Kim BS, Ahn KJ, Kim YJ, Jung AK et al (2005) MR imaging of orbital inflammatory pseudotumors with extraorbital extension. Korean J Radiol 6:82–88CrossRefPubMedPubMedCentral
44.
go back to reference Yuen SJ, Rubin PA (2003) Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome. Arch Ophthalmol 121:491–499CrossRefPubMed Yuen SJ, Rubin PA (2003) Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome. Arch Ophthalmol 121:491–499CrossRefPubMed
Metadata
Title
The pterygopalatine fossa: imaging anatomy, communications, and pathology revisited
Authors
Sonam Tashi
Bela S. Purohit
Minerva Becker
Pravin Mundada
Publication date
01-08-2016
Publisher
Springer Berlin Heidelberg
Published in
Insights into Imaging / Issue 4/2016
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1007/s13244-016-0498-1

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