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Open Access 01-11-2010 | Review

Imaging findings in craniofacial childhood rhabdomyosarcoma

Authors: Nicole J. M. Freling, Johannes H. M. Merks, Peerooz Saeed, Alfons J. M. Balm, Johannes Bras, Bradley R. Pieters, Judit A. Adam, Rick R. van Rijn

Published in: Pediatric Radiology | Issue 11/2010

Abstract

Rhabdomyosarcoma (RMS) is the commonest paediatric soft-tissue sarcoma constituting 3–5% of all malignancies in childhood. RMS has a predilection for the head and neck area and tumours in this location account for 40% of all childhood RMS cases. In this review we address the clinical and imaging presentations of craniofacial RMS, discuss the most appropriate imaging techniques, present characteristic imaging features and offer an overview of differential diagnostic considerations. Post-treatment changes will be briefly addressed.

Miller RW, Young JL Jr, Novakovic B (1995) Childhood cancer. Cancer 75:395–405CrossRefPubMed

Sengupta S, Pal R (2009) Clinicopathological correlates of pediatric head and neck cancer. J Cancer Res Ther 5:181–185CrossRefPubMed

Crist WM, Anderson JR, Meza JL et al (2001) Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol 19:3091–3102PubMed

Raney RB, Meza J, Anderson JR et al (2002) Treatment of children and adolescents with localized parameningeal sarcoma: experience of the Intergroup Rhabdomyosarcoma Study Group protocols IRS-II through -IV, 1978–1997. Med Pediatr Oncol 38:22–32CrossRefPubMed

Lobe TE, Wiener ES, Hays DM et al (1994) Neonatal rhabdomyosarcoma: the IRS experience. J Pediatr Surg 29:1167–1170CrossRefPubMed

Ragab AH, Heyn R, Tefft M et al (1986) Infants younger than 1 year of age with rhabdomyosarcoma. Cancer 58:2606–2610CrossRefPubMed

Dickson PV, Davidoff AM (2006) Malignant neoplasms of the head and neck. Semin Pediatr Surg 15:92–98CrossRefPubMed

Van Rijn RR, Wilde JC, Bras J et al (2008) Imaging findings in noncraniofacial childhood rhabdomyosarcoma. Pediatr Radiol 38:617–634CrossRefPubMed

Stevens MC, Rey A, Bouvet N et al (2005) Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology—SIOP Malignant Mesenchymal Tumor 89. J Clin Oncol 23:2618–2628CrossRefPubMed

10.

Hicks J, Flaitz C (2002) Rhabdomyosarcoma of the head and neck in children. Oral Oncol 38:450–459CrossRefPubMed

11.

Oberlin O, Rey A, Anderson J et al (2001) Treatment of orbital rhabdomyosarcoma: survival and late effects of treatment—results of an international workshop. J Clin Oncol 19:197–204PubMed

12.

Razek AA, Elsorogy LG, Soliman NY et al (2009) Dynamic susceptibility contrast perfusion MR imaging in distinguishing malignant from benign head and neck tumors: A pilot study. Eur J Radiol Aug 18 [Epub ahead of print]

13.

Kim EE, Valenzuela RF, Kumar AJ et al (2000) Imaging and clinical spectrum of rhabdomyosarcoma in children. Clin Imaging 24:257–262CrossRefPubMed

14.

Daldrup-Link HE, Franzius C, Link TM et al (2001) Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. AJR 177:229–236PubMed

15.

Goo HW, Choi SH, Ghim T et al (2005) Whole-body MRI of paediatric malignant tumours: comparison with conventional oncological imaging methods. Pediatr Radiol 35:766–773CrossRefPubMed

16.

van den Brekel MW, Castelijns JA, Stel HV et al (1993) Modern imaging techniques and ultrasound-guided aspiration cytology for the assessment of neck node metastases: a prospective comparative study. Eur Arch Otorhinolaryngol 250:11–17CrossRefPubMed

17.

Volker T, Denecke T, Steffen I et al (2007) Positron emission tomography for staging of pediatric sarcoma patients: results of a prospective multicenter trial. J Clin Oncol 25:5435–5441CrossRefPubMed

18.

Abdel Razek AA, Soliman NY, Elkhamary S et al (2006) Role of diffusion-weighted MR imaging in cervical lymphadenopathy. Eur Radiol 16:1468–1477CrossRefPubMed

19.

Mody RJ, Bui C, Hutchinson RJ et al (2010) FDG PET imaging of childhood sarcomas. Pediatr Blood Cancer 54:222–227PubMed

20.

Al-Ibraheem A, Buck A, Krause BJ et al (2009) Clinical Applications of FDG PET and PET/CT in Head and Neck Cancer. J Oncol Aug 20 [Epub ahead of print]

21.

Abdel Razek AA, Kandeel AY, Soliman N et al (2007) Role of diffusion-weighted echo-planar MR imaging in differentiation of residual or recurrent head and neck tumors and posttreatment changes. AJNR 28:1146–1152CrossRefPubMed

22.

Humphries PD, Sebire NJ, Siegel MJ et al (2007) Tumors in pediatric patients at diffusion-weighted MR imaging: apparent diffusion coefficient and tumor cellularity. Radiology 245:848–854CrossRefPubMed

23.

Hermans R (2008) Posttreatment imaging in head and neck cancer. Eur J Radiol 66:501–511CrossRefPubMed

24.

Srinivasan A, Dvorak R, Perni K et al (2008) Differentiation of benign and malignant pathology in the head and neck using 3 T apparent diffusion coefficient values: early experience. AJNR 29:40–44CrossRefPubMed

25.

Sakamoto J, Yoshino N, Okochi K et al (2009) Tissue characterization of head and neck lesions using diffusion-weighted MR imaging with SPLICE. Eur J Radiol 69:260–268CrossRefPubMed

26.

King AD, Ahuja AT, Yeung DK et al (2007) Malignant cervical lymphadenopathy: diagnostic accuracy of diffusion-weighted MR imaging. Radiology 245:806–813CrossRefPubMed

27.

Vandecaveye V, De Keyzer F, Vander Poorten V et al (2009) Head and neck squamous cell carcinoma: value of diffusion-weighted MR imaging for nodal staging. Radiology 251:134–146CrossRefPubMed

28.

Abdel Razek AAK, Megahed Alem S, Denewer A et al (2008) Role of diffusion-weighted magnetic resonance imaging in differentiation between the viable and necrotic parts of head and neck tumors. Acta Radiol 49:364–370CrossRef

29.

Kataoka M, Ueda H, Koyama T et al (2005) Contrast-enhanced volumetric interpolated breath-hold examination compared with spin-echo T1-weighted imaging of head and neck tumors. AJR 184:313–319PubMed

30.

Lavini C, Pikaart BP, de Jonge MC et al (2009) Region of interest and pixel-by-pixel analysis of dynamic contrast enhanced magnetic resonance imaging parameters and time-intensity curve shapes: a comparison in chondroid tumors. Magn Reson Imaging 27:62–68CrossRefPubMed

31.

van Rijswijk CS, Geirnaerdt MJ, Hogendoorn PC et al (2003) Dynamic contrast-enhanced MR imaging in monitoring response to isolated limb perfusion in high-grade soft tissue sarcoma: initial results. Eur Radiol 13:1849–1858CrossRefPubMed

32.

Schuetze SM, Baker LH, Benjamin RS et al (2008) Selection of response criteria for clinical trials of sarcoma treatment. Oncologist 13:32–40CrossRefPubMed

33.

Voss SD, Reaman GH, Kaste SC et al (2009) The ALARA concept in pediatric oncology. Pediatr Radiol 39:1142–1146CrossRefPubMed

34.

Brenner D, Elliston C, Hall E et al (2001) Estimated risks of radiation induced fatal cancer from pediatric CT. AJR 176:289–296PubMed

35.

Paterson A, Frush DP, Donnelly LF (2001) Helical CT of the body: are settings adjusted for pediatric patients? AJR 176:297–301PubMed

36.

Jager PL, Hoekstra HJ, Leeuw J et al (2000) Routine bone scintigraphy in primary staging of soft tissue sarcoma; Is it worthwhile? Cancer 89:1726–1731CrossRefPubMed

37.

Tateishi U, Hosono A, Makimoto A et al (2009) Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma. Ann Nucl Med 23:155–161CrossRefPubMed

38.

Klem ML, Grewal RK, Wexler LH et al (2007) PET for staging in rhabdomyosarcoma: an evaluation of PET as an adjunct to current staging tools. J Pediatr Hematol Oncol 29:9–14CrossRefPubMed

39.

Jungehuelsing M, Sittel C, Fischbach R et al (2000) Limitations of magnetic resonance imaging in the evaluation of perineural tumor spread causing facial nerve paralysis. Arch Otolaryngol Head Neck Surg 126:506–510PubMed

40.

Majoie CB, Hulsmans FJ, Verbeeten B Jr et al (1997) Perineural tumor extension along the trigeminal nerve: magnetic resonance imaging findings. Eur J Radiol 24:191–205CrossRefPubMed

41.

Nemzek WR, Hecht S, Gandour-Edwards R et al (1998) Perineural spread of head and neck tumors: how accurate is MR imaging? AJNR 19:701–706PubMed

42.

Sigal R, Monnet O, de Baere T et al (1992) Adenoid cystic carcinoma of the head and neck: evaluation with MR imaging and clinical-pathologic correlation in 27 patients. Radiology 184:95–101PubMed

43.

Borges A, Casselman J (2007) Imaging the cranial nerves: part II: primary and secondary neoplastic conditions and neurovascular conflicts. Eur Radiol 17:2332–2344CrossRefPubMed

44.

Leong SP, Cady B, Jablons DM et al (2006) Clinical patterns of metastasis. Cancer Metastasis Rev 25:221–232CrossRefPubMed

45.

Oberlin O, Rey A, Lyden E et al (2008) Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups. J Clin Oncol 26:2384–2389CrossRefPubMed

46.

Paulino AC, Bauman N, Simon JH et al (2003) Local control of parameningeal rhabdomyosarcoma: outcomes in non-complete responders to chemoradiation. Med Pediatr Oncol 41:118–122CrossRefPubMed

47.

Spunt SL, Anderson JR, Teot LA et al (2001) Routine brain imaging is unwarranted in asymptomatic patients with rhabdomyosarcoma arising outside of the head and neck region that is metastatic at diagnosis: a report from the Intergroup Rhabdomyosarcoma Study Group. Cancer 92:121–125CrossRefPubMed

48.

Sohaib SA, Moseley I, Wright JE (1998) Orbital rhabdomyosarcoma—the radiological characteristics. Clin Radiol 53:357–362CrossRefPubMed

49.

Shields CL, Shields JA, Honavar SG et al (2001) Clinical spectrum of primary ophthalmic rhabdomyosarcoma. Ophthalmology 108:2284–2292CrossRefPubMed

50.

Vanel D, Shapeero LG, de Baere T et al (1994) MR imaging in the follow-up of malignant and aggressive soft-tissue tumors: results of 511 examinations. Radiology 190:263–268PubMed

51.

Yang WT, Kwan WH, Li CK et al (1997) Imaging of pediatric head and neck rhabdomyosarcomas with emphasis on magnetic resonance imaging and a review of the literature. Pediatr Hematol Oncol 14:243–257CrossRefPubMed

52.

Yousem DM, Lexa FJ, Bilaniuk LT et al (1990) Rhabdomyosarcomas in the head and neck: MR imaging evaluation. Radiology 177:683–686PubMed

53.

Harnsberger HR, Osborn AG (1991) Differential diagnosis of head and neck lesions based on their space of origin. 1. The suprahyoid part of the neck. AJR 157:147–154PubMed

54.

Buwalda J, Schouwenburg PF, Blank LE et al (2003) A novel local treatment strategy for advanced stage head and neck rhabdomyosarcomas in children: results of the AMORE protocol. Eur J Cancer 39:1594–1602CrossRefPubMed

55.

Wenig BM, Heffness CS (2008) Non-epithelial malignant salivary gland tumours. In: Atlas of head and neck pathology, 2nd edn. Elsevier, Amsterdam, p 685

56.

Mafee MF (2005) The nasopharynx—nasopharyngeal carcinoma. Valvassori’s imaging of the head and neck, 2nd edn. Thieme, NY, USA, p 569

57.

Demirci H, Shields CL, Karatza EC et al (2008) Orbital lymphoproliferative tumors: analysis of clinical features and systemic involvement in 160 cases. Ophthalmology 115:1626–1631CrossRefPubMed

58.

Toma P, Granata C, Rossi A et al (2007) Multimodality imaging of Hodgkin disease and non-Hodgkin lymphomas in children. Radiographics 27:1335–1354CrossRefPubMed

59.

Cotterill SJ, Ahrens S, Paulussen M et al (2000) Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. J Clin Oncol 18:3108–3114PubMed

60.

van den Berg H, Heinen RC, van der Pal HJ et al (2009) Extra-osseous Ewing sarcoma. Pediatr Hematol Oncol 26:175–185CrossRefPubMed

61.

Bradley P, McClelland L, Mehta D (2007) Paediatric salivary gland epithelial neoplasms. ORL J Otorhinolaryngol Relat Spec 69:137–145PubMed

62.

Noh BW, Park SW, Chun JE et al (2009) Granulocytic Sarcoma in the Head and Neck: CT and MR Imaging Findings. Clin Exp Otorhinolaryngol 2:66–71CrossRefPubMed

63.

Vosoghi H, Rodriguez-Galindo C, Wilson MW (2009) Orbital involvement in langerhans cell histiocytosis. Ophthalmic Plast Reconstr Surg 25:430–433CrossRef

64.

Raney RB, Anderson JR, Kollath J et al (2000) Late effects of therapy in 94 patients with localized rhabdomyosarcoma of the orbit: Report from the Intergroup Rhabdomyosarcoma Study (IRS)-III, 1984–1991. Med Pediatr Oncol 34:413–420CrossRefPubMed

65.

Blank LE, Koedooder K, van der Grient HN et al (2009) Brachytherapy as Part of the Multidisciplinary Treatment of Childhood Rhabdomyosarcomas of the Orbit. Int J Radiat Oncol Biol Phys Oct 26 [Epub ahead of print]

66.

Yock T, Schneider R, Friedmann A et al (2005) Proton radiotherapy for orbital rhabdomyosarcoma: clinical outcome and a dosimetric comparison with photons. Int J Radiat Oncol Biol Phys 63:1161–1168PubMed

67.

Pappo AS, Meza JL, Donaldson SS et al (2003) Treatment of localized nonorbital, nonparameningeal head and neck rhabdomyosarcoma: lessons learned from intergroup rhabdomyosarcoma studies III and IV. J Clin Oncol 21:638–645CrossRefPubMed

68.

Schouwenburg PF, Kupperman D, Bakker FP et al (1998) New combined treatment of surgery, radiotherapy, and reconstruction in head and neck rhabdomyosarcoma in children: the AMORE protocol. Head Neck 20:283–292CrossRefPubMed

69.

Blank LE, Koedooder K, Pieters BR et al (2009) The AMORE protocol for advanced-stage and recurrent nonorbital rhabdomyosarcoma in the head-and-neck region of children: a radiation oncology view. Int J Radiat Oncol Biol Phys 74:1555–1562PubMed

70.

McCarville MB, Christie R, Daw NC et al (2005) PET/CT in the evaluation of childhood sarcomas. AJR 184:1293–1304PubMed

71.

Gilles R, Couanet D, Chevret S et al (1991) Importance of a post-therapeutic residue in the prognosis of head and neck rhabdomyosarcoma in children. Eur J Radiol 13:187–191CrossRefPubMed

72.

Burke M, Anderson JR, Kao SC et al (2007) Assessment of response to induction therapy and its influence on 5-year failure-free survival in group III rhabdomyosarcoma: the Intergroup Rhabdomyosarcoma Study-IV experience—a report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. J Clin Oncol 25:4909–4913CrossRefPubMed

73.

Rodeberg DA, Stoner JA, Hayes-Jordan A et al (2009) Prognostic significance of tumor response at the end of therapy in group III rhabdomyosarcoma: a report from the children’s oncology group. J Clin Oncol 27:3705–3711CrossRefPubMed

74.

De Schepper AM, Bloem JL (2007) Soft tissue tumors: grading, staging, and tissue-specific diagnosis. Top Magn Reson Imaging 18:431–444CrossRefPubMed

75.

Peng F, Rabkin G, Muzik O (2006) Use of 2-deoxy-2-[F-18]-fluoro-D-glucose positron emission tomography to monitor therapeutic response by rhabdomyosarcoma in children: report of a retrospective case study. Clin Nucl Med 31:394–397CrossRefPubMed

76.

Bisogno G, Bergeron C, Jenney M et al (2005) EpSSG RMS 2005; a protocol for non-metastatic rhabdomyosarcoma. 2005 Jun 1, Padova

Title: Imaging findings in craniofacial childhood rhabdomyosarcoma
Authors: Nicole J. M. Freling
Johannes H. M. Merks
Peerooz Saeed
Alfons J. M. Balm
Johannes Bras
Bradley R. Pieters
Judit A. Adam
Rick R. van Rijn
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 11/2010
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-010-1787-3

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Springer Medicine

Imaging findings in craniofacial childhood rhabdomyosarcoma

Abstract

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Abstract

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