Skip to main content
Top
Published in: Insights into Imaging 2/2016

Open Access 01-04-2016 | Opinion

How to diagnose acute appendicitis: ultrasound first

Authors: Gerhard Mostbeck, E. Jane Adam, Michael Bachmann Nielsen, Michel Claudon, Dirk Clevert, Carlos Nicolau, Christiane Nyhsen, Catherine M. Owens

Published in: Insights into Imaging | Issue 2/2016

Login to get access

Abstract

Acute appendicitis (AA) is a common abdominal emergency with a lifetime prevalence of about 7 %. As the clinical diagnosis of AA remains a challenge to emergency physicians and surgeons, imaging modalities have gained major importance in the diagnostic work-up of patients with suspected AA in order to keep both the negative appendectomy rate and the perforation rate low. Introduced in 1986, graded-compression ultrasound (US) has well-established direct and indirect signs for diagnosing AA. In our opinion, US should be the first-line imaging modality, as graded-compression US has excellent specificity both in the paediatric and adult patient populations. As US sensitivity is limited, and non-diagnostic US examinations with non-visualization of the appendix are more a rule than an exception, diagnostic strategies and algorithms after non-diagnostic US should focus on clinical reassessment and complementary imaging with MRI/CT if indicated. Accordingly, both ionizing radiation to our patients and cost of pre-therapeutic diagnosis of AA will be low, with low negative appendectomy and perforation rates.
Main Messages
Ultrasound (US) should be the first imaging modality for diagnosing acute appendicitis (AA).
Primary US for AA diagnosis will decrease ionizing radiation and cost.
Sensitivity of US to diagnose AA is lower than of CT/MRI.
Non-visualization of the appendix should lead to clinical reassessment.
Complementary MRI or CT may be performed if diagnosis remains unclear.
Literature
1.
go back to reference Gwynn LK (2001) The diagnosis of acute appendicitis: clinical assessement versus computed tomography evaluation. J Emerg Med 21:119–123CrossRefPubMed Gwynn LK (2001) The diagnosis of acute appendicitis: clinical assessement versus computed tomography evaluation. J Emerg Med 21:119–123CrossRefPubMed
3.
go back to reference Shogilev DJ, Duus N, Odom SR, Shapiro NI (2014) Diagnosing appendicitis: evidence-based review of the diagnostic approach in 2014. West J Emerg Med 15:859–871CrossRefPubMedPubMedCentral Shogilev DJ, Duus N, Odom SR, Shapiro NI (2014) Diagnosing appendicitis: evidence-based review of the diagnostic approach in 2014. West J Emerg Med 15:859–871CrossRefPubMedPubMedCentral
4.
go back to reference Janszky I, Mukamal KJ, Dalman C, Hammar N, Ahnve S (2011) Childhood appendectomy, tonsillectomy, and risk for premature acute myocardial infarction – a nationwide population-based cohort study. Eur Heart J 32:2290–2296CrossRefPubMed Janszky I, Mukamal KJ, Dalman C, Hammar N, Ahnve S (2011) Childhood appendectomy, tonsillectomy, and risk for premature acute myocardial infarction – a nationwide population-based cohort study. Eur Heart J 32:2290–2296CrossRefPubMed
5.
go back to reference Puylaert JB (1986) Acute appendicitis: US evaluation using graded compression. Radiology 161:691–695CrossRefPubMed Puylaert JB (1986) Acute appendicitis: US evaluation using graded compression. Radiology 161:691–695CrossRefPubMed
8.
go back to reference Addiss DG, Shaffer N, Fowler BS, Tauxe RV (1990) The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 132:910–925PubMed Addiss DG, Shaffer N, Fowler BS, Tauxe RV (1990) The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 132:910–925PubMed
9.
go back to reference Birnbaum BA, Wilson SR (2000) Appendicitis in the millennium. Rad 215:337–348CrossRef Birnbaum BA, Wilson SR (2000) Appendicitis in the millennium. Rad 215:337–348CrossRef
10.
go back to reference Murphy J (1904) Two thousand operations for appendicitis, with deductions from his personal experience. Am J Med Sci 129:187–211 Murphy J (1904) Two thousand operations for appendicitis, with deductions from his personal experience. Am J Med Sci 129:187–211
11.
go back to reference Thompson G (2012) Clinical scoring systems in the management of suspected appendicitis in children. In: Appendicitis - A Collection of Essays from Around the World. Edited by Dr. Anthony Lander. InTech. ISBN 978-953-307-814-4 Thompson G (2012) Clinical scoring systems in the management of suspected appendicitis in children. In: Appendicitis - A Collection of Essays from Around the World. Edited by Dr. Anthony Lander. InTech. ISBN 978-953-307-814-4
12.
go back to reference Jones RP, Jeffrey RB, Shah BR, Desser TS, Rosenberg J, Olcott EW (2015) Journal Club: the Alvarado score as a method for reducing the number of CT studies when appendiceal ultrasound fails to visualize the appendix in adults. Am J Roentgenol 204:519–526CrossRef Jones RP, Jeffrey RB, Shah BR, Desser TS, Rosenberg J, Olcott EW (2015) Journal Club: the Alvarado score as a method for reducing the number of CT studies when appendiceal ultrasound fails to visualize the appendix in adults. Am J Roentgenol 204:519–526CrossRef
13.
go back to reference Bachur RG, Callahan MJ, Monuteaux MC, Rangel SJ (2015) Integration of ultrasound findings and clinical score in the diagnostic evaluation of pediatric appendicitis. J Pediatr 166:1134–1139CrossRefPubMed Bachur RG, Callahan MJ, Monuteaux MC, Rangel SJ (2015) Integration of ultrasound findings and clinical score in the diagnostic evaluation of pediatric appendicitis. J Pediatr 166:1134–1139CrossRefPubMed
14.
go back to reference Alfraih Y, Postuma R, Keijzer R (2014) How do you diagnose appendicitis? An international evaluation of methods. Int J Surg 12:67–70CrossRefPubMed Alfraih Y, Postuma R, Keijzer R (2014) How do you diagnose appendicitis? An international evaluation of methods. Int J Surg 12:67–70CrossRefPubMed
15.
go back to reference Boonstra PA, van Veen RN, Stockmann HB (2014) Less negative appendectomies due to imaging in patients with suspected appendicitis. Surg Endosc Boonstra PA, van Veen RN, Stockmann HB (2014) Less negative appendectomies due to imaging in patients with suspected appendicitis. Surg Endosc
16.
go back to reference Puylaert JBCM (1990) Ultrasound of appendicitis and its differential diagnosis. Springer, Berlin Heidelberg New York, ISBN 3-540-52727-3 CrossRef Puylaert JBCM (1990) Ultrasound of appendicitis and its differential diagnosis. Springer, Berlin Heidelberg New York, ISBN 3-540-52727-3 CrossRef
17.
go back to reference Coyne SM, Zhang B, Trout AT (2014) Does appendiceal diameter change with age? A sonographic study. Am J Roentgenol 203:1120–1126CrossRef Coyne SM, Zhang B, Trout AT (2014) Does appendiceal diameter change with age? A sonographic study. Am J Roentgenol 203:1120–1126CrossRef
18.
go back to reference Göya C, Hamidi C, Okur MH et al. (2014) The utility of acoustic radiation force impulse imaging in diagnosing acute appendicitis and stage its severity. Diagn Interv Radiol 20:453–458CrossRefPubMedPubMedCentral Göya C, Hamidi C, Okur MH et al. (2014) The utility of acoustic radiation force impulse imaging in diagnosing acute appendicitis and stage its severity. Diagn Interv Radiol 20:453–458CrossRefPubMedPubMedCentral
19.
go back to reference Cha S-W, Kim IK, Kim YW. (2014) Quantitative measurement of elasticity of the appendix using shear wave elastography in patients with suspected acute appendicitis. PLos ONE 9(7): e101292, doi: 10.1371/journal.pone.0101292 Cha S-W, Kim IK, Kim YW. (2014) Quantitative measurement of elasticity of the appendix using shear wave elastography in patients with suspected acute appendicitis. PLos ONE 9(7): e101292, doi: 10.​1371/​journal.​pone.​0101292
20.
go back to reference Incesu L, Yazicioglu AK, Selcuk MB, Ozem N (2004) Contrast-enhanced power-Doppler US in the diagnosis of acute appendicitis. Eur J Radiol 50:201–209CrossRefPubMed Incesu L, Yazicioglu AK, Selcuk MB, Ozem N (2004) Contrast-enhanced power-Doppler US in the diagnosis of acute appendicitis. Eur J Radiol 50:201–209CrossRefPubMed
21.
go back to reference Ripolles T, Martinez-Perez MJ, Paredes JM et al. (2013) Contrast-enhanced ultrasound in the differential between phlegmon and abscess in Crohn’s disease and other abdominal conditions. Eur J Radiol 83:e525–e531CrossRef Ripolles T, Martinez-Perez MJ, Paredes JM et al. (2013) Contrast-enhanced ultrasound in the differential between phlegmon and abscess in Crohn’s disease and other abdominal conditions. Eur J Radiol 83:e525–e531CrossRef
22.
go back to reference Trout TA, Towbin AJ, Fierke SR, Zhang B, Larson DB (2015) Appendiceal diameter as a predictor of appendicitis in children: improved diagnosis with three diagnostic categories derived from a logistic predictive model. Eur Radiol Trout TA, Towbin AJ, Fierke SR, Zhang B, Larson DB (2015) Appendiceal diameter as a predictor of appendicitis in children: improved diagnosis with three diagnostic categories derived from a logistic predictive model. Eur Radiol
23.
go back to reference Al-Khayal KA, Al-Omran MA (2007) Computed tomography and ultrasonography in the diagnosis of equivocal acute appendicitis. A meta-analysis. Saudi Med J 28:173–180PubMed Al-Khayal KA, Al-Omran MA (2007) Computed tomography and ultrasonography in the diagnosis of equivocal acute appendicitis. A meta-analysis. Saudi Med J 28:173–180PubMed
24.
go back to reference Pinto F, Pinto A, Russo A et al. (2013) Accuracy of ultrasonography in the diagnosis of acute appendicitis in adult patients: review of the literature. Crit Ultrasound J 5(Suppl 1):S2CrossRefPubMedPubMedCentral Pinto F, Pinto A, Russo A et al. (2013) Accuracy of ultrasonography in the diagnosis of acute appendicitis in adult patients: review of the literature. Crit Ultrasound J 5(Suppl 1):S2CrossRefPubMedPubMedCentral
25.
go back to reference Van Randen A, Bipat S, Zwindermann AH, Ubbink DT, Stoker J, Boermeester MA (2008) Acute appendicitis: Meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease. Rad 249:97–106CrossRef Van Randen A, Bipat S, Zwindermann AH, Ubbink DT, Stoker J, Boermeester MA (2008) Acute appendicitis: Meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease. Rad 249:97–106CrossRef
26.
go back to reference Piyarom P, Kaewlai R (2014) False-negative appendicitis at ultrasound: nature and association. Ultrasound Med Biol 40:1483–1489CrossRefPubMed Piyarom P, Kaewlai R (2014) False-negative appendicitis at ultrasound: nature and association. Ultrasound Med Biol 40:1483–1489CrossRefPubMed
28.
go back to reference Ross MJ, Liu H, Netherton SJ et al. (2014) Outcomes of children with suspected appendicitis and incompletely visualized appendix on ultrasound. Acad Emerg Med 21:538–542CrossRefPubMed Ross MJ, Liu H, Netherton SJ et al. (2014) Outcomes of children with suspected appendicitis and incompletely visualized appendix on ultrasound. Acad Emerg Med 21:538–542CrossRefPubMed
29.
go back to reference Estey A, Poonai N, Lim R (2013) Appendix not seen: the predictive value of secondary inflammatory sonographic signs. Pediatr Emerg Care 29:435–439CrossRefPubMed Estey A, Poonai N, Lim R (2013) Appendix not seen: the predictive value of secondary inflammatory sonographic signs. Pediatr Emerg Care 29:435–439CrossRefPubMed
30.
go back to reference Shah BR, Stewart J, Jeffery RB, Olcott EW (2014) Value of short-interval computed tomography when sonography fails to visualize the appendix and shows otherwise normal findings. J Ultrasound Med 33:1589–1595CrossRefPubMed Shah BR, Stewart J, Jeffery RB, Olcott EW (2014) Value of short-interval computed tomography when sonography fails to visualize the appendix and shows otherwise normal findings. J Ultrasound Med 33:1589–1595CrossRefPubMed
31.
go back to reference Srinivasan A, Servaes S, Pena A, Darge K (2015) Utility of CT after sonography for suspected appendicitis in children: integration of a clinical scoring system with a staged imaging protocol. Emerg Radiol 22:31–42CrossRefPubMed Srinivasan A, Servaes S, Pena A, Darge K (2015) Utility of CT after sonography for suspected appendicitis in children: integration of a clinical scoring system with a staged imaging protocol. Emerg Radiol 22:31–42CrossRefPubMed
32.
go back to reference Ross MJ, Liu H, Metherton SJ et al. (2014) Outcomes of children with suspected appendicitis and incompletely visualized appendix on ultrasound. Acad Emerg Med 21:538–542CrossRefPubMed Ross MJ, Liu H, Metherton SJ et al. (2014) Outcomes of children with suspected appendicitis and incompletely visualized appendix on ultrasound. Acad Emerg Med 21:538–542CrossRefPubMed
33.
go back to reference Kaewlai R, Lertlumsakulsub W, Srichareon P (2015) Body mass index, pain score and Alvarado score are useful predictors of appendix visualization at ultrasound in adults. Ultrasound Med Biol 41:1605–1611CrossRefPubMed Kaewlai R, Lertlumsakulsub W, Srichareon P (2015) Body mass index, pain score and Alvarado score are useful predictors of appendix visualization at ultrasound in adults. Ultrasound Med Biol 41:1605–1611CrossRefPubMed
34.
go back to reference Koseekriniramol V, Kaewlai R (2015) Abdominal wall thickness is not useful to predict appendix visualization on sonography in adult patients with suspected appendicitis. J Clin Ultrasound 43:269–276CrossRefPubMed Koseekriniramol V, Kaewlai R (2015) Abdominal wall thickness is not useful to predict appendix visualization on sonography in adult patients with suspected appendicitis. J Clin Ultrasound 43:269–276CrossRefPubMed
35.
go back to reference Ramarajan N, Krishamoorthi R, Barth R et al. (2009) An interdisciplinary initiative to reduce radiation exposure: evaluation of appendicitis in a pediatric emergency department with a clinical assessement supported by a staged ultrasound and computed tomography pathway. Acad Emerg Med 16:1258–1265CrossRefPubMed Ramarajan N, Krishamoorthi R, Barth R et al. (2009) An interdisciplinary initiative to reduce radiation exposure: evaluation of appendicitis in a pediatric emergency department with a clinical assessement supported by a staged ultrasound and computed tomography pathway. Acad Emerg Med 16:1258–1265CrossRefPubMed
37.
go back to reference Leewenburgh MM, Stockmann HB, Bouma WH et al. (2014) A simple clinical decision rule to rule out appendicitis in patients with nondiagnostic ultrasound results. Acad Emerg Med 21:488–496 Leewenburgh MM, Stockmann HB, Bouma WH et al. (2014) A simple clinical decision rule to rule out appendicitis in patients with nondiagnostic ultrasound results. Acad Emerg Med 21:488–496
38.
go back to reference Schuh S, Chan K, Langer JC et al. (2015) Properties of serial ultrasound clinical diagnostic pathway in suspected appendicitis and related computed tomography use. Acad Emerg Med 22:404–414CrossRef Schuh S, Chan K, Langer JC et al. (2015) Properties of serial ultrasound clinical diagnostic pathway in suspected appendicitis and related computed tomography use. Acad Emerg Med 22:404–414CrossRef
39.
go back to reference Kotagal M, Richards MK, Chapman T et al. (2015) Improving ultrasound quality to reduce computed tomography use in pediatric appendicitis: the Safe and Sound campaign. Am J Surg 209:896–900CrossRefPubMed Kotagal M, Richards MK, Chapman T et al. (2015) Improving ultrasound quality to reduce computed tomography use in pediatric appendicitis: the Safe and Sound campaign. Am J Surg 209:896–900CrossRefPubMed
40.
go back to reference Van Atta AJ, Baskin HJ, Maves CK et al. (2015) Implementing an ultrasound-based protocol for diagnosing appendicitis while maintaining diagnostic accuracy. Pediatr Radiol 45:678–685CrossRefPubMed Van Atta AJ, Baskin HJ, Maves CK et al. (2015) Implementing an ultrasound-based protocol for diagnosing appendicitis while maintaining diagnostic accuracy. Pediatr Radiol 45:678–685CrossRefPubMed
41.
go back to reference Larson DB, Trout AT, Fierke SR, Towbin AJ (2015) Improvement in diagnostic accuracy of ultrasound of the pediatric appendix through the use of equivocal interpretative categories. Am J Roentgenol 294:849–856CrossRef Larson DB, Trout AT, Fierke SR, Towbin AJ (2015) Improvement in diagnostic accuracy of ultrasound of the pediatric appendix through the use of equivocal interpretative categories. Am J Roentgenol 294:849–856CrossRef
42.
go back to reference Krajevski S, Brown J, Phang PT, Raval M, Brown JC (2011) Impact of computed tomography of the abdomen on clinical outcomes in patients with acute right lower quadrant pain: a meta-analysis. Can J Surg 54(1):43–53CrossRef Krajevski S, Brown J, Phang PT, Raval M, Brown JC (2011) Impact of computed tomography of the abdomen on clinical outcomes in patients with acute right lower quadrant pain: a meta-analysis. Can J Surg 54(1):43–53CrossRef
43.
go back to reference Pickhardt PJ, Lawrence EM, Pooler BD, Bruce RJ (2011) Diagnostic performance of multidetector computed tomography for suspected acute appendicitis. Ann Intern Med 154:789–796CrossRefPubMed Pickhardt PJ, Lawrence EM, Pooler BD, Bruce RJ (2011) Diagnostic performance of multidetector computed tomography for suspected acute appendicitis. Ann Intern Med 154:789–796CrossRefPubMed
44.
go back to reference Doria AS, Moineddin R, Kellenberger CJ et al. (2006) US or CT for Diagnosis of Appendicitis in Children and Adults? A Meta-Analysis. Rad 241:83–94CrossRef Doria AS, Moineddin R, Kellenberger CJ et al. (2006) US or CT for Diagnosis of Appendicitis in Children and Adults? A Meta-Analysis. Rad 241:83–94CrossRef
45.
go back to reference Kim K, Kim YH, Kim AY et al. (2012) Lowe-dose abdominal CT for evaluating suspected appendicitis. N Engl J Med 366:1596–1605CrossRefPubMed Kim K, Kim YH, Kim AY et al. (2012) Lowe-dose abdominal CT for evaluating suspected appendicitis. N Engl J Med 366:1596–1605CrossRefPubMed
46.
go back to reference Atema JJ, Gans SL, Van Randen A et al. (2015) Comparison of imaging strategies with conditional versus immediate contrast-enhanced computed tomography in patients with clinical suspicion of acute appendicitis. Eur Radiol Atema JJ, Gans SL, Van Randen A et al. (2015) Comparison of imaging strategies with conditional versus immediate contrast-enhanced computed tomography in patients with clinical suspicion of acute appendicitis. Eur Radiol
47.
go back to reference Sim JY, Kim HJ, Yeon JW et al. (2013) Added value of ultrasound re-evaluation for patients with equicocal CT findings of acute appendicitis: a preliminary study. Eur Radiol 23:1882–1890CrossRefPubMed Sim JY, Kim HJ, Yeon JW et al. (2013) Added value of ultrasound re-evaluation for patients with equicocal CT findings of acute appendicitis: a preliminary study. Eur Radiol 23:1882–1890CrossRefPubMed
48.
go back to reference Israel GM, Malguria N, McCarthy S, Copel J, Weinreb J (2008) MRI vs. ultrasound for suspected appendicitis during pregnancy. J Magn Reson Imaging 28:428–433CrossRefPubMed Israel GM, Malguria N, McCarthy S, Copel J, Weinreb J (2008) MRI vs. ultrasound for suspected appendicitis during pregnancy. J Magn Reson Imaging 28:428–433CrossRefPubMed
49.
go back to reference Rosines LA, Chow DS, Lampl BS et al. (2014) Value of gadolinium-enhanced MRI in detection of acute appendicitis in children and adolescents. Am J Radiol 203:W543–W548 Rosines LA, Chow DS, Lampl BS et al. (2014) Value of gadolinium-enhanced MRI in detection of acute appendicitis in children and adolescents. Am J Radiol 203:W543–W548
50.
go back to reference Thieme ME, Leeuwenburgh MM, Valdehueza ZD et al. (2014) Diagnostic accuracy and patient acceptance of MRI in children with suspected appendicitis. Eur Radiol 24:630–637CrossRefPubMed Thieme ME, Leeuwenburgh MM, Valdehueza ZD et al. (2014) Diagnostic accuracy and patient acceptance of MRI in children with suspected appendicitis. Eur Radiol 24:630–637CrossRefPubMed
51.
go back to reference Aspelund G, Fingeret A, Gross E et al. (2014) Ultrasonography/MRI versus CT for diagnosing appendicitis. Pediatrics 133:586–593CrossRefPubMed Aspelund G, Fingeret A, Gross E et al. (2014) Ultrasonography/MRI versus CT for diagnosing appendicitis. Pediatrics 133:586–593CrossRefPubMed
52.
go back to reference Herliczek TW, Swenson DW, Mayo-Smith W (2013) Utility of MRI after inconclusive ultrasound in pediatric patients with suspected appendicitis: retrospective review of 60 consecutive patients. AJR 200:969–973CrossRefPubMed Herliczek TW, Swenson DW, Mayo-Smith W (2013) Utility of MRI after inconclusive ultrasound in pediatric patients with suspected appendicitis: retrospective review of 60 consecutive patients. AJR 200:969–973CrossRefPubMed
53.
go back to reference Rosen MP, Ding A, Blake MA et al. (2011) ACR Appropriateness Criteria® right lower quadrant pain – suspected appendicitis. J Am Coll Radiol 8:749–755CrossRefPubMed Rosen MP, Ding A, Blake MA et al. (2011) ACR Appropriateness Criteria® right lower quadrant pain – suspected appendicitis. J Am Coll Radiol 8:749–755CrossRefPubMed
54.
go back to reference Parker L, Nazarian LN, Gingold EL, Palit CD, Hoey CJ, Frangos AJ (2014) Cost and radiation savings of partial substitution of ultrasound for CT in appendicitis evaluation: a national projection. Am J Roentgenol 202:124–135CrossRef Parker L, Nazarian LN, Gingold EL, Palit CD, Hoey CJ, Frangos AJ (2014) Cost and radiation savings of partial substitution of ultrasound for CT in appendicitis evaluation: a national projection. Am J Roentgenol 202:124–135CrossRef
55.
go back to reference Wan MJ, Krahn M, Ungar WJ et al. (2009) Acute appendicitis in young children: cost-effectiveness of US versus CT in diagnosis – a Markov decision analytic model. Rad 250:378–386CrossRef Wan MJ, Krahn M, Ungar WJ et al. (2009) Acute appendicitis in young children: cost-effectiveness of US versus CT in diagnosis – a Markov decision analytic model. Rad 250:378–386CrossRef
Metadata
Title
How to diagnose acute appendicitis: ultrasound first
Authors
Gerhard Mostbeck
E. Jane Adam
Michael Bachmann Nielsen
Michel Claudon
Dirk Clevert
Carlos Nicolau
Christiane Nyhsen
Catherine M. Owens
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
Insights into Imaging / Issue 2/2016
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1007/s13244-016-0469-6

Other articles of this Issue 2/2016

Insights into Imaging 2/2016 Go to the issue