Published in:
01-04-2019 | Case Report
Primary Hyperparathyroidism in Pregnancy: A Multicenter Case Series of 4 Patients from Northern India
Authors:
Ajay Aggarwal, Roopak Wadhwa, Vivek Aggarwal, Arun Pande, Swadesh Kumar Singh, Ankur Gahlot, Deependra Narayan Singh, Abhinav Sharma
Published in:
The Journal of Obstetrics and Gynecology of India
|
Special Issue 1/2019
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Excerpt
Primary hyperparathyroidism (PHPT) is third most common endocrine disorder. Middle-aged women suffer three times more than men. The annual incidence of PHPT in pregnancy is around 8 cases per 100,000 of population [
1]. The physiological changes during normal pregnancy, like slight drop in serum calcium due to gestational hypoalbuminemia, increased glomerular filtration rate, transplacental transfer and low-normal intact parathyroid hormone (PTH), may obscure the diagnosis. However, ionized calcium levels are similar to that of non-pregnant state. So, PHPT in pregnancy may be more frequent than previously reported. The three major pathological conditions associated with PHPT include parathyroid adenoma, hyperplasia and carcinoma. Approximately, 85% cases of PHPT in pregnancy are due to single adenoma. The symptoms are usually non-specific as they overlap with those of pregnancy. …