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10-05-2022 | Cancer Therapy | Review Article

Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review

Authors: Nader Salari, Farahnaz Faraji, Sima Jafarpour, Fatemeh Faraji, Shna Rasoulpoor, Sadat Dokaneheifard, Masoud Mohammadi

Published in: Indian Journal of Surgical Oncology | Issue 4/2022

Abstract

Chrysin is a natural bioactive compound that is extracted from many trees, honey, and propolis. Chrysin has several pharmacological activities such as anti-inflammatory, anti-cancer, and antioxidant properties. This study was performed to evaluate the anti-cancer activities of chrysin in cancer therapy. The present study was conducted by systematic review of studies published up to August 2021. Related studies were identified by searching Web of Science (WoS), PubMed, Science Direct, SID, MagIran, Scopus, and Google Scholar databases. The keywords of chrysin, cancer, anti-cancer, and cancer therapy were used for searching. The quality of the studies was assessed by the CONSORT checklist. A total of 21 studies were identified. The results of studies showed that chrysin has an anticancer effect by stimulating apoptosis in a wide range of human cells and rats. Chrysin is also an important factor in inhibiting tumor growth and neoplasticity. Chrysin inhibits the growth and proliferation of cancer cells by inducing cytotoxic effects. Therefore, due to the antitumor effects of chrysin and its safety and non-toxicity towards normal cells, this compound can be considered as an adjuvant along with chemotherapeutic agents in cancer treatment.

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Title: Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
Authors: Nader Salari
Farahnaz Faraji
Sima Jafarpour
Fatemeh Faraji
Shna Rasoulpoor
Sadat Dokaneheifard
Masoud Mohammadi
Publication date: 10-05-2022
Publisher: Springer India
Keyword: Cancer Therapy
Published in: Indian Journal of Surgical Oncology / Issue 4/2022
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-022-01550-6

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Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review

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