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Nuclear Medicine and Molecular Imaging
Published in: Nuclear Medicine and Molecular Imaging 2/2016

01-06-2016 | Review

Instrumentation for Time-of-Flight Positron Emission Tomography

Authors: Muhammad Nasir Ullah, Eva Pratiwi, Jimin Cheon, Hojong Choi, Jung Yeol Yeom

Published in: Nuclear Medicine and Molecular Imaging | Issue 2/2016

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Abstract

Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient’s body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.
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Metadata
Title
Instrumentation for Time-of-Flight Positron Emission Tomography
Authors
Muhammad Nasir Ullah
Eva Pratiwi
Jimin Cheon
Hojong Choi
Jung Yeol Yeom
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
Nuclear Medicine and Molecular Imaging / Issue 2/2016
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-016-0401-5

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