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Nuclear Medicine and Molecular Imaging
Published in: Nuclear Medicine and Molecular Imaging 3/2017

01-09-2017 | Interesting Image

68Gallium-Arginine-Glycine-Aspartic Acid and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull

Authors: Akintunde Orunmuyi, Moshe Modiselle, Thabo Lengana, Thomas Ebenhan, Mariza Vorster, Mike Sathekge

Published in: Nuclear Medicine and Molecular Imaging | Issue 3/2017

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Abstract

We report the case of a 32 year-old male with Chondroblastic Osteosarcoma of the skull, which was imaged with both 18[F]fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and 68Gallium-arginine-glycine-aspartic acid (68Ga-RGD) PET/CT. The 18F-FDG PET/CT did not demonstrate the tumour, whereas the 68Ga-RGD PET/CT clearly depicted a left-sided frontal tumour. 68Ga-RGD PET/CT may be a clinically useful imaging modality for early detection of recurrent osteosarcoma, considering the limitations of 18F-FDG PET in a setting of low glycolytic activity.
Literature
1.
2.
Cai H, Conti PS. RGD-based PET tracers for imaging receptor integrin αvβ3 expression. J Labelled Comp Radiopharm. 2013;56:264–79.CrossRefPubMed
3.
Pedersen MW, Holm S, Lund EL, et al. Coregulation of glucose uptake and vascular endothelial growth factor (VEGF) in two small-cell lung cancer (SCLC) sublines in vivo and in vitro. Neoplasia. 2001;3:80–7.CrossRefPubMedPubMedCentral
4.
Quartuccio N, Treglia G, Salsano M, et al. The role of Fluorine-18-Fluorodeoxyglucose positron emission tomography in staging and restaging of patients with osteosarcoma. Radiol Oncol. 2013;47:97–102.CrossRefPubMedPubMedCentral
5.
Cheng W, Wu Z, Liang S, et al. Comparison of 18F-AIF-NOTA-PRGD2 and 18F-FDG uptake in lymph node metastasis of differentiated thyroid cancer. PLoS One. 2014;9:e100521.CrossRefPubMedPubMedCentral
6.
Paik JY, Ko BH, Choe YS, et al. PMA-enhanced neutrophil [18F]FDG uptake is independent of integrin occupancy but requires PI3K activity. Nucl Med Biol. 2005;32:561–6.CrossRefPubMed
7.
Im HJ, Kim TS, Park SY, et al. Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma. Eur J Nucl Med Mol Imaging. 2012;39:39–49.CrossRefPubMed
8.
Elisabeth Blom E, Velikyan I, Sergio Estrada S, et al. (68)Ga-Labeling of RGD peptides and biodistribution. Int J Clin Exp Med. 2012;5:165–72.PubMedPubMedCentral
Metadata
Title
68Gallium-Arginine-Glycine-Aspartic Acid and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull
Authors
Akintunde Orunmuyi
Moshe Modiselle
Thabo Lengana
Thomas Ebenhan
Mariza Vorster
Mike Sathekge
Publication date
01-09-2017
Publisher
Springer Berlin Heidelberg
Published in
Nuclear Medicine and Molecular Imaging / Issue 3/2017
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-016-0400-6

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