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Translational Stroke Research
Published in: Translational Stroke Research 2/2024

16-03-2023 | Sleep Apnea | Review

Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options

Authors: Basma Mohamed, Keerthi Yarlagadda, Zachary Self, Alexandra Simon, Frank Rigueiro, Maryam Sohooli, Stephan Eisenschenk, Sylvain Doré

Published in: Translational Stroke Research | Issue 2/2024

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Abstract

Sleep-disordered breathing (SDB) can be a sequela of stroke caused by vascular injury to vital respiratory centers, cerebral edema, and increased intracranial pressure of space-occupying lesions. Likewise, obstructive sleep apnea (OSA) contributes to increased stroke risk through local mechanisms such as impaired ischemic cerebrovascular response and systemic effects such as promoting atherosclerosis, hypercoagulability, cardiac arrhythmias, vascular-endothelial dysfunction, and metabolic syndrome. The impact of OSA on stroke outcomes has been established, yet it receives less attention in national guidelines on stroke management than hyperglycemia and blood pressure dysregulation. Furthermore, whether untreated OSA worsens stroke outcomes is not well-described in the literature. This scoping review provides an updated investigation of the correlation between OSA and stroke, including inter-relational pathophysiology. This review also highlights the importance of OSA treatment and its role in stroke outcomes. Knowledge of pathophysiology, the inter-relationship between these common disorders, and the impact of OSA therapy on outcomes affect the clinical management of patients with acute ischemic stroke. In addition, understanding the relationship between stroke outcomes and pre-existing OSA will allow clinicians to predict outcomes while treating acute stroke.
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Metadata
Title
Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options
Authors
Basma Mohamed
Keerthi Yarlagadda
Zachary Self
Alexandra Simon
Frank Rigueiro
Maryam Sohooli
Stephan Eisenschenk
Sylvain Doré
Publication date
16-03-2023
Publisher
Springer US
Published in
Translational Stroke Research / Issue 2/2024
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-023-01123-x

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