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Translational Stroke Research
Published in: Translational Stroke Research 2/2015

01-04-2015 | Commentary

Perihematoma Edema: A Potential Translational Target in Intracerebral Hemorrhage?

Authors: Magdy Selim, Kevin N. Sheth

Published in: Translational Stroke Research | Issue 2/2015

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Excerpt

Secondary injury in intracerebral hemorrhage (ICH) is becoming increasingly well characterized and is the subject of intense investigations. After the initial injury caused by tissue disruption and mass effect of the hematoma, products of coagulation, clot retraction, and hemoglobin breakdown initiate a secondary cascade of deleterious events including apoptosis, necrosis, iron-mediated oxidative stress, inflammation, autophagy, and edema formation [1‐3]. Tissue swelling, in particular, may contribute to neurological deterioration and disability. …
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Metadata
Title
Perihematoma Edema: A Potential Translational Target in Intracerebral Hemorrhage?
Authors
Magdy Selim
Kevin N. Sheth
Publication date
01-04-2015
Publisher
Springer US
Published in
Translational Stroke Research / Issue 2/2015
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-015-0389-7

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