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Translational Stroke Research
Published in: Translational Stroke Research 1/2015

01-02-2015 | Letter

What is Early Brain Injury?

Author: Hidenori Suzuki

Published in: Translational Stroke Research | Issue 1/2015

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Excerpt

The term “early brain injury (EBI)” that was introduced in 2004 [1] is a concept to explain acute pathophysiological events that occur in brain before onset of cerebral vasospasm within the first 72 h of aneurysmal subarachnoid hemorrhage (SAH). EBI is now believed to be more important than cerebral vasospasm, a classically important determinant of poor outcome, in post-SAH outcome [2‐4]. …
Literature
1.
Kusaka G, Ishikawa M, Nanda A, Granger DN, Zhang JH. Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2004;24(8):916–25.PubMedCrossRef
2.
Fujii M, Yan J, Rolland WB, Soejima Y, Caner B, Zhang JH. Early brain injury, an evolving frontier in subarachnoid hemorrhage research. Transl Stroke Res. 2013;4(4):432–46.PubMedCentralPubMedCrossRef
3.
Tso MK, Macdonald RL. Subarachnoid hemorrhage: a review of experimental studies on the microcirculation and the neurovascular unit. Transl Stroke Res. 2014;5(2):174–89.PubMedCrossRef
4.
Zhang JH. Vascular neural network in subarachnoid hemorrhage. Transl Stroke Res. 2014;5(4):423–8.PubMedCrossRef
5.
Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/american Stroke Association. Stroke. 2012;43(6):1711–37.
6.
International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet. 2002;360(9342):1267–74.CrossRef
7.
Qureshi AI, Vazquez G, Tariq N, Suri MF, Lakshminarayan K, Lanzino G. Impact of international subarachnoid aneurysm trial results on treatment of ruptured intracranial aneurysms in the United States. J Neurosurg. 2011;114(3):834–41.PubMedCrossRef
8.
Taki W, Sakai N, Suzuki H. PRESAT group. Factors predicting retreatment and residual aneurysms at 1year after endovascular coiling for ruptured cerebral aneurysms: prospective registry of subarachnoid aneurysms treatment (PRESAT) in Japan. Neuroradiology. 2012;54(6):597–606.PubMedCrossRef
9.
Zanaty M, Chalouhi N, Tjoumakaris SI, Rosenwasser RH, Jabbour PM. Endovascular management of cerebral aneurysm: review of the literature. Transl Stroke Res. 2014;5(2):199–206.PubMedCrossRef
10.
Hamada K, Miura Y, Toma N, Miyamoto K, Imanaka-Yoshida K, Matsushima S, et al. Gellan sulfate core platinum coil with tenascin-C promotes intra-aneurysmal organization in rats. Transl Stroke Res. 2014;5(5):595–603.PubMedCrossRef
11.
Taki W, Sakai N, Suzuki H, PRESAT Group. Determinants of poor outcome after aneurysmal subarachnoid hemorrhage when both clipping and coiling are available: Prospective Registry of Subarachnoid Aneurysms Treatment (PRESAT) in Japan. World Neurosurg. 2011;76(5):437–45.
12.
Fu C, Yu W, Sun L, Li D, Zhao C. Early cerebral infarction following aneurysmal subarachnoid hemorrhage: frequency, risk factors, patterns, and prognosis. Curr Neurovasc Res. 2013;10(4):316–24.PubMedCrossRef
13.
Suzuki H, Sozen T, Hasegawa Y, Chen W, Zhang JH. Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice. Stroke. 2009;40(12):3872–5.PubMedCentralPubMedCrossRef
14.
Suzuki H, Sakurai M, Fujimoto M, Tsuchiya T, Sakaida H, Taki W. Complete recovery from aneurysmal subarachnoid hemorrhage associated with out-of-hospital cardiopulmonary arrest. Eur J Emerg Med. 2010;17(1):42–4.PubMedCrossRef
15.
Radolf S, Smoll N, Drenckhahn C, Dreier JP, Vajkoczy P, Sarrafzadeh AS. Cerebral lactate correlates with early onset pneumonia after aneurysmal SAH. Transl Stroke Res. 2014;5(2):278–85.PubMedCrossRef
16.
Vergouwen MDI, Vermeulen M, van Gijn J, Rinkel GJE, Wijdicks EF, Muizelaar JP, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies. Proposal of a Multidisciplinary Research Group Stroke. 2010;41(10):2391–5.
17.
Brathwaite S, Macdonald RL. Current management of delayed cerebral ischemia: update from results of recent clinical trials. Transl Stroke Res. 2014;5(2):207–26.PubMedCrossRef
18.
Ko SB, Choi HA, Carpenter AM, Helbok R, Schmidt JM, Badjatia N, et al. Quantitative analysis of hemorrhage volume for predicting delayed cerebral ischemia after subarachnoid hemorrhage. Stroke. 2011;42(3):669–74.PubMedCrossRef
19.
Crowley RW, Medel R, Dumont AS, Ilodigwe D, Kassell NF, Mayer SA, et al. Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage. Stroke. 2011;42(4):919–23.PubMedCrossRef
20.
Naraoka M, Munakata A, Matsuda N, Shimamura N, Ohkuma H. Suppression of the Rho/Rho-kinase pathway and prevention of cerebral vasospasm by combination treatment with statin and fasudil after subarachnoid hemorrhage in rabbit. Transl Stroke Res. 2013;4(3):368–74.PubMedCentralPubMedCrossRef
21.
Shimamura N, Ohkuma H. Phenotypic transformation of smooth muscle in vasospasm after aneurysmal subarachnoid hemorrhage. Transl Stroke Res. 2014;5(3):357–64.PubMedCrossRef
22.
Edvinsson L, Larsen SS, Maddahi A, Nielsen J. Plasticity of cerebrovascular smooth muscle cells after subarachnoid hemorrhage. Transl Stroke Res. 2014;5(3):365–76.PubMedCrossRef
23.
Woitzik J, Dreier JP, Hecht N, Fiss I, Sandow N, Major S, et al. Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2012;32(2):203–12.PubMedCentralPubMedCrossRef
24.
Shiba M, Fujimoto M, Imanaka-Yoshida K, Yoshida T, Taki W, Suzuki H. Tenascin-C causes neuronal apoptosis after subarachnoid hemorrhage in rats. Transl Stroke Res. 2014;5(2):238–47.PubMedCrossRef
25.
Suzuki H, Kanamaru K, Shiba M, Fujimoto M, Kawakita F, Imanaka-Yoshida K, et al. Tenascin-C is a possible mediator between initial brain injury and vasospasm-related and -unrelated delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl. 2015;120:117–21.
26.
27.
Bühler D, Schüller K, Plesnila N. Protocol for the induction of subarachnoid hemorrhage in mice by perforation of the circle of Willis with an endovascular filament. Transl Stroke Res. 2014;5(6):653–9.PubMedCentralPubMedCrossRef
28.
Marbacher S, Nevzati E, Croci D, Erhardt S, Muroi C, Jakob SM, et al. The rabbit shunt model of subarachnoid haemorrhage. Transl Stroke Res. 2014;5(6):669–80.PubMedCrossRef
29.
Mori K. Double cisterna magna blood injection model of experimental subarachnoid hemorrhage in dogs. Transl Stroke Res. 2014;5(6):647–52.PubMedCrossRef
30.
Pluta RM, Bacher J, Skopets B, Hoffmann V. A non-human primate model of aneurismal subarachnoid hemorrhage (SAH). Transl Stroke Res. 2014;5(6):681–91.PubMedCrossRef
31.
Metadata
Title
What is Early Brain Injury?
Author
Hidenori Suzuki
Publication date
01-02-2015
Publisher
Springer US
Published in
Translational Stroke Research / Issue 1/2015
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-014-0380-8

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