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Published in:

01-02-2015 | Review Article

The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model

Authors: Yuichiro Kikkawa, Ryota Kurogi, Tomio Sasaki

Published in: Translational Stroke Research | Issue 1/2015

Abstract

Over the past 30 years, the rabbit subarachnoid hemorrhage model (SAH) has been used for investigating the post-hemorrhage pathology, especially with respect to understanding of the mechanisms of cerebral vasospasm. However, the molecular mechanisms of cerebral vasospasm remain to be elucidated. Furthermore, it is not clear whether the rabbit SAH model is suitable for the investigation of pathological conditions other than cerebral vasospasm, such as early brain injury. Therefore, the properties of the rabbit SAH model need to be validated, and the reasons for using the rabbit should be clarified. This review explores the settings and technical issues of establishing a rabbit cisterna magna single and double blood injection SAH model and discusses the characteristics and feasibilities of the models.

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Title: The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model
Authors: Yuichiro Kikkawa
Ryota Kurogi
Tomio Sasaki
Publication date: 01-02-2015
Publisher: Springer US
Published in: Translational Stroke Research / Issue 1/2015
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-014-0375-5

At a glance: The STEP trials

Springer Medicine

The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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