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Published in: Indian Journal of Gastroenterology 1/2020

01-02-2020 | Fatty Liver | Case Series

Acute exacerbated severe form of nonalcoholic steatohepatitis leading to acute-on-chronic liver failure: A case series

Published in: Indian Journal of Gastroenterology | Issue 1/2020

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Abstract

We present three patients with uncontrolled metabolic syndrome and acute-on-chronic liver failure in whom, after meticulous evaluation, the acute event was found to be a severe and exacerbated form of nonalcoholic steatohepatitis (NASH), a novel entry in the natural history of non-alcoholic fatty liver disease. This novel disease entity was described partially, 17 years before by Caldwell et al. We discuss current literature, pertinent features, and outcomes associated with a severe form of NASH, which is associated with high mortality.
Literature
1.
go back to reference Benedict M, Zhang X. Non-alcoholic fatty liver disease: an expanded review. World J Hepatol. 2017;9:715–32.CrossRef Benedict M, Zhang X. Non-alcoholic fatty liver disease: an expanded review. World J Hepatol. 2017;9:715–32.CrossRef
2.
3.
go back to reference Kleiner DE, Makhlouf HR. Histology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in adults and children. Clin Liver Dis. 2016;20:293–312.CrossRef Kleiner DE, Makhlouf HR. Histology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in adults and children. Clin Liver Dis. 2016;20:293–312.CrossRef
4.
go back to reference Caldwell SH, Hespenheide EE. Subacute liver failure in obese women. Am J Gastroenterol. 2002;97:2058–62.CrossRef Caldwell SH, Hespenheide EE. Subacute liver failure in obese women. Am J Gastroenterol. 2002;97:2058–62.CrossRef
5.
go back to reference Nirei K, Ogihara N, Kawamura W, Kang W, Moriyama M. Rapid recovery from acute liver failure secondary to pancreatoduodenectomy-related non-alcoholic steatohepatitis. Case Rep Gastroenterol. 2013;7:49–55. Nirei K, Ogihara N, Kawamura W, Kang W, Moriyama M. Rapid recovery from acute liver failure secondary to pancreatoduodenectomy-related non-alcoholic steatohepatitis. Case Rep Gastroenterol. 2013;7:49–55.
6.
go back to reference Tsai JH, Ferrell LD, Tan V, Yeh MM, Sarkar M, Gill RM. Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition. Mod Pathol. 2017;30:834–42. Tsai JH, Ferrell LD, Tan V, Yeh MM, Sarkar M, Gill RM. Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition. Mod Pathol. 2017;30:834–42.
7.
go back to reference Axley P, Ahmed Z, Arora S, et al. NASH is the most rapidly growing etiology for acute-on-chronic liver failure-related hospitalization and disease burden in the United States: a population-based study. Liver Transpl. 2019;25:695–705.CrossRef Axley P, Ahmed Z, Arora S, et al. NASH is the most rapidly growing etiology for acute-on-chronic liver failure-related hospitalization and disease burden in the United States: a population-based study. Liver Transpl. 2019;25:695–705.CrossRef
8.
go back to reference Day CP. NASH-related liver failure: one hit too many? Am J Gastroenterol. 2002;97:1872–4.CrossRef Day CP. NASH-related liver failure: one hit too many? Am J Gastroenterol. 2002;97:1872–4.CrossRef
9.
go back to reference Azer SA. Re: Caldwell and Hespenheide-subacute liver failure in obese women. Am J Gastroenterol. 2003;98:1656–7.PubMed Azer SA. Re: Caldwell and Hespenheide-subacute liver failure in obese women. Am J Gastroenterol. 2003;98:1656–7.PubMed
Metadata
Title
Acute exacerbated severe form of nonalcoholic steatohepatitis leading to acute-on-chronic liver failure: A case series
Publication date
01-02-2020
Published in
Indian Journal of Gastroenterology / Issue 1/2020
Print ISSN: 0254-8860
Electronic ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-020-01028-9

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