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01-01-2018 | Editorial

Ayurvedic and herbal medicine-induced liver injury: It is time to wake up and take notice

Author: Harshad Devarbhavi

Published in: Indian Journal of Gastroenterology | Issue 1/2018

Excerpt

Sir William Osler, the renowned physician and one of the founding professors of Johns Hopkins Hospital once remarked, “the desire to take medicine is perhaps the greatest feature which distinguishes man from animals.” A number of prescription drugs used by mankind, including but not limited to antibiotics and antiviral agents, anesthetics, antihypertensives, and analgesics, have undoubtedly enhanced the quality of life and helped cure many chronic diseases. …

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Navarro VJ, Barnhart H, Bonkovsky HL, et al. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. Hepatology. 2014;60:1399–408.

Zhao P, Wang C, Liu W, et al. Causes and outcomes of acute liver failure in China. PLoS One. 2013;8:e80991.

Suk KT, Kim DJ, Kim CH, et al. A prospective nationwide study of drug-induced liver injury in Korea. Am J Gastroenterol. 2012;107:1380–7.CrossRefPubMed

Hillman L, Gottfried M, Whitsett M, et al. Clinical features and outcomes of complementary and alternative medicine induced acute liver failure and injury. Am J Gastroenterol. 2016;111:958–65.

Zhu Y, Niu M, Chen J, et al. Hepatobiliary and pancreatic: comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients. J Gastroenterol Hepatol. 2016;31:1476–82.

Philips CA, Paramaguru R, Joy AK, Antony KL, Augustine P. Clinical outcomes, histopathologic patterns and chemical analysis of ayurveda and herbal medicine associated with severe liver injury—a single center experience from South India. Indian J Gastroenterol. 2018; 37: https://doi.org/10.1007/s12664-017-0815-8.

Devarbhavi H, Choudhury A, Reddy V, et al. Acute on chronic liver failure secondary to drugs: causes, outcome and predictors of mortality. J Hepatol. 2016;64:232A.CrossRef

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Saper RB, Phillips RS, Sehgal A, et al. Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet. JAMA. 2008;300:915–23.

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Title: Ayurvedic and herbal medicine-induced liver injury: It is time to wake up and take notice
Author: Harshad Devarbhavi
Publication date: 01-01-2018
Publisher: Springer India
Published in: Indian Journal of Gastroenterology / Issue 1/2018
Print ISSN: 0254-8860
Electronic ISSN: 0975-0711
DOI: https://doi.org/10.1007/s12664-018-0820-6

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