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01-03-2018 | Original Article

No increased risk of perforation during colonoscopy in patients undergoing propofol versus traditional sedation: A meta-analysis

Authors: Minmin Xue, Jian Tian, Jing Zhang, Hongbin Zhu, Jun Bai, Sujuan Zhang, Qili Wang, Shuge Wang, Xuzheng Song, Donghong Ma, Jia Li, Yongmin Zhang, Wei Li, Dongxu Wang

Published in: Indian Journal of Gastroenterology | Issue 2/2018

Abstract

Background and Aims

The safety of propofol sedation during colonoscopy remains unclear, and we performed a meta-analysis to assess the risk of perforation in patients undergoing propofol vs. traditional sedation.

Methods

MEDLINE, CBM, VIP, CNKI, and Wanfang databases were searched up to December 2016. Two reviewers independently assessed abstract of those searched articles. Data about perforation condition in propofol and traditional sedation groups were extracted and combined using the random effects model.

Results

A total of 19 studies were included in the current meta-analysis. Compared to traditional sedation, propofol sedation did not increase the risk of perforation (RD = − 0.00, 95% CI − 0.00~0.00, p = 0.98; subgroup analysis: OR = 1.30, 95% CI 0.83~2.05, p = 0.25).

Conclusion

This meta-analysis suggested that propofol sedation did not increase the risk of perforation compared to traditional sedation during colonoscopy.

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Title: No increased risk of perforation during colonoscopy in patients undergoing propofol versus traditional sedation: A meta-analysis
Authors: Minmin Xue
Jian Tian
Jing Zhang
Hongbin Zhu
Jun Bai
Sujuan Zhang
Qili Wang
Shuge Wang
Xuzheng Song
Donghong Ma
Jia Li
Yongmin Zhang
Wei Li
Dongxu Wang
Publication date: 01-03-2018
Publisher: Springer India
Published in: Indian Journal of Gastroenterology / Issue 2/2018
Print ISSN: 0254-8860
Electronic ISSN: 0975-0711
DOI: https://doi.org/10.1007/s12664-017-0814-9

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Results

Conclusion

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