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Published in: Indian Journal of Gastroenterology 1/2016

01-01-2016 | Original Article

Non-variceal upper gastrointestinal bleeding in cirrhotic patients in Nile Delta

Authors: Mamdouh Ahmed Gabr, Mohamed Abd El-Raouf Tawfik, Abd Allah Ahmed El-Sawy

Published in: Indian Journal of Gastroenterology | Issue 1/2016

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Abstract

Background and Study Aims

Acute upper gastrointestinal bleeding (AUGIB) in cirrhotic patients occurs mainly from esophageal and gastric varices; however, quite a large number of cirrhotic patients bleed from other sources as well. The aim of the present work is to determine the prevalence of non-variceal UGIB as well as its different causes among the cirrhotic portal hypertensive patients in Nile Delta.

Methods

Emergency upper gastrointestinal (UGI) endoscopy for AUGIB was done in 650 patients. Out of these patients, 550 (84.6 %) patients who were proved to have cirrhosis were the subject of the present study.

Results

From all cirrhotic portal hypertensive patients, 415 (75.5 %) bled from variceal sources (esophageal and gastric) while 135 (24.5 %) of them bled from non-variceal sources. Among variceal sources of bleeding, esophageal varices were much more common than gastric varices. Peptic ulcer was the most common non-variceal source of bleeding.

Conclusions

Non-variceal bleeding in cirrhosis was not frequent, and sources included peptic ulcer, portal hypertensive gastropathy, and erosive disease of the stomach and duodenum.
Literature
1.
go back to reference Romcea A, Tanttau M, Seicean A, Pascu O. The etiology of upper gastrointestinal bleeding in cirrhotic patients. Clujul Med. 2013;86:21–3.PubMedPubMedCentral Romcea A, Tanttau M, Seicean A, Pascu O. The etiology of upper gastrointestinal bleeding in cirrhotic patients. Clujul Med. 2013;86:21–3.PubMedPubMedCentral
2.
go back to reference Kalafateli M, Triantos C, Nikolopoulou V, Burroughs A. Non-variceal gastrointestinal bleeding in patients with liver cirrhosis: a review. Dig Dis Sci. 2012;57:2743–54.CrossRefPubMed Kalafateli M, Triantos C, Nikolopoulou V, Burroughs A. Non-variceal gastrointestinal bleeding in patients with liver cirrhosis: a review. Dig Dis Sci. 2012;57:2743–54.CrossRefPubMed
3.
go back to reference González-González JA, García-Compean D, Vázquez-Elizondo G, Garza-Galindo A, Jáquez-Quintana JO, Maldonado-Garza H. Nonvariceal upper gastrointestinal bleeding in patients with liver cirrhosis. Clinical features, outcomes and predictors of in-hospital mortality. A prospective study. Ann Hepatol. 2011;10:287–95.PubMed González-González JA, García-Compean D, Vázquez-Elizondo G, Garza-Galindo A, Jáquez-Quintana JO, Maldonado-Garza H. Nonvariceal upper gastrointestinal bleeding in patients with liver cirrhosis. Clinical features, outcomes and predictors of in-hospital mortality. A prospective study. Ann Hepatol. 2011;10:287–95.PubMed
4.
go back to reference Afessa B, Kubilis PS. Upper gastrointestinal bleeding in patients with hepatic cirrhosis: clinical course and mortality prediction. Am J Gastroenterol. 2000;95:484–9.CrossRefPubMed Afessa B, Kubilis PS. Upper gastrointestinal bleeding in patients with hepatic cirrhosis: clinical course and mortality prediction. Am J Gastroenterol. 2000;95:484–9.CrossRefPubMed
5.
go back to reference Lecleire S, Di Fiore F, Merle V, et al. Acute upper gastrointestinal bleeding in patients with liver cirrhosis and in noncirrhotic patients: epidemiology and predictive factors of mortality in a prospective multicenter population-based study. J Clin Gastroenterol. 2005;39:321–7.CrossRefPubMed Lecleire S, Di Fiore F, Merle V, et al. Acute upper gastrointestinal bleeding in patients with liver cirrhosis and in noncirrhotic patients: epidemiology and predictive factors of mortality in a prospective multicenter population-based study. J Clin Gastroenterol. 2005;39:321–7.CrossRefPubMed
6.
go back to reference Matei D, Groza I, Furnea B, et al. Predictors of variceal or nonvariceal source of upper gastrointestinal bleeding. An etiology predictive score established and validated in a tertiary referral center. J Gastrointestin Liver Dis. 2013;22:379–84.PubMed Matei D, Groza I, Furnea B, et al. Predictors of variceal or nonvariceal source of upper gastrointestinal bleeding. An etiology predictive score established and validated in a tertiary referral center. J Gastrointestin Liver Dis. 2013;22:379–84.PubMed
7.
go back to reference Charif I, Saada K, Mellouki I, et al. Predictors of early rebleeding and mortality after acute variceal haemorrhage in patients with cirrhosis. Open J Gastroenterol. 2013;3:317–21.CrossRef Charif I, Saada K, Mellouki I, et al. Predictors of early rebleeding and mortality after acute variceal haemorrhage in patients with cirrhosis. Open J Gastroenterol. 2013;3:317–21.CrossRef
8.
go back to reference Seo Y, Kim Y, Ahn S, et al. Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis. J Korean Med Sci. 2008;23:635–43.CrossRefPubMedPubMedCentral Seo Y, Kim Y, Ahn S, et al. Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis. J Korean Med Sci. 2008;23:635–43.CrossRefPubMedPubMedCentral
9.
go back to reference Odelowo OO, Smoot DT, Kim K. Upper gastrointestinal bleeding in patients with liver cirrhosis. J Natl Med Assoc. 2002;94:712–5.PubMedPubMedCentral Odelowo OO, Smoot DT, Kim K. Upper gastrointestinal bleeding in patients with liver cirrhosis. J Natl Med Assoc. 2002;94:712–5.PubMedPubMedCentral
10.
go back to reference van Leerdam ME, Vreeburg EM, Rauws EA, et al. Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. Am J Gastroenterol. 2003;98:1494–9.CrossRefPubMed van Leerdam ME, Vreeburg EM, Rauws EA, et al. Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. Am J Gastroenterol. 2003;98:1494–9.CrossRefPubMed
11.
go back to reference Di Fiore F, Lecleire S, Merle V, et al. Changes in characteristics and outcome of acute upper gastrointestinal hemorrhage: a comparison of epidemiology and practices between 1996 and 2000 in a multicenter French study. Eur J Gastroenterol Hepatol. 2005;17:641–7.CrossRefPubMed Di Fiore F, Lecleire S, Merle V, et al. Changes in characteristics and outcome of acute upper gastrointestinal hemorrhage: a comparison of epidemiology and practices between 1996 and 2000 in a multicenter French study. Eur J Gastroenterol Hepatol. 2005;17:641–7.CrossRefPubMed
12.
go back to reference Svoboda P, Konecny M, Martinek A, Hrabovsky V, Prochazka V, Ehrmann J. Acute upper gastrointestinal bleeding in liver cirrhosis patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012;156:266–70.CrossRefPubMed Svoboda P, Konecny M, Martinek A, Hrabovsky V, Prochazka V, Ehrmann J. Acute upper gastrointestinal bleeding in liver cirrhosis patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012;156:266–70.CrossRefPubMed
13.
go back to reference Schafer E, Rusznyak K, Visnyei Z, et al. Upper gastrointestinal bleeding in patients with cirrhosis. Z Gastroenterol. 2011;49:A76. Schafer E, Rusznyak K, Visnyei Z, et al. Upper gastrointestinal bleeding in patients with cirrhosis. Z Gastroenterol. 2011;49:A76.
14.
go back to reference Bambha K, Kim WR, Pedersen R, Bida JP, Kremers WK, Kamath PS. Predictors of early re-bleeding and mortality after acute variceal haemorrhage in patients with cirrhosis. Gut. 2008;57:814–20.CrossRefPubMed Bambha K, Kim WR, Pedersen R, Bida JP, Kremers WK, Kamath PS. Predictors of early re-bleeding and mortality after acute variceal haemorrhage in patients with cirrhosis. Gut. 2008;57:814–20.CrossRefPubMed
15.
go back to reference D’Amico G, De Franchis R, Cooperative Study Group. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology. 2003;38:599–612.CrossRefPubMed D’Amico G, De Franchis R, Cooperative Study Group. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology. 2003;38:599–612.CrossRefPubMed
16.
go back to reference Lyles T, Elliott A, Rockey DC. A risk scoring system to predict in-hospital mortality in patients with cirrhosis presenting with upper gastrointestinal bleeding. J Clin Gastroenterol. 2014;48:712–20.CrossRefPubMed Lyles T, Elliott A, Rockey DC. A risk scoring system to predict in-hospital mortality in patients with cirrhosis presenting with upper gastrointestinal bleeding. J Clin Gastroenterol. 2014;48:712–20.CrossRefPubMed
17.
go back to reference Constantin V, Socea B, Popa F, et al. Epidemiological aspects and risk factors in the outcome of variceal eso-gastric bleeding at cirrhosis patients. JAQM. 2008;3:316–24. Constantin V, Socea B, Popa F, et al. Epidemiological aspects and risk factors in the outcome of variceal eso-gastric bleeding at cirrhosis patients. JAQM. 2008;3:316–24.
18.
go back to reference Targownik L, Dhruve M, Inegbu E. Differentiating variceal from non-variceal bleeding using pre-endoscopic clinical characteristics. CDDW Abstracts 2012. Targownik L, Dhruve M, Inegbu E. Differentiating variceal from non-variceal bleeding using pre-endoscopic clinical characteristics. CDDW Abstracts 2012.
19.
go back to reference Gabr M, El-Shall N, Ghazy M, et al. A retrospective study of upper gastrointestinal bleeding in Middle Delta. Gut. 2009;58:A104.CrossRef Gabr M, El-Shall N, Ghazy M, et al. A retrospective study of upper gastrointestinal bleeding in Middle Delta. Gut. 2009;58:A104.CrossRef
20.
go back to reference Laine L. Treatment of non-variceal upper GI hemorrhage: what is happening in the real world. Am J Gastroenterol. 2004;99:1247–9.CrossRefPubMed Laine L. Treatment of non-variceal upper GI hemorrhage: what is happening in the real world. Am J Gastroenterol. 2004;99:1247–9.CrossRefPubMed
21.
go back to reference Cremers I, Ribeiro S. Management of variceal and nonvariceal upper gastrointestinal bleeding in patients with cirrhosis. Therap Adv Gastroenterol. 2014;7:206–16.CrossRefPubMedPubMedCentral Cremers I, Ribeiro S. Management of variceal and nonvariceal upper gastrointestinal bleeding in patients with cirrhosis. Therap Adv Gastroenterol. 2014;7:206–16.CrossRefPubMedPubMedCentral
23.
go back to reference Morsy KH, Ghaliony MA, Mohammed HS. Outcomes and predictors of in-hospital mortality among cirrhotic patients with non-variceal upper gastrointestinal bleeding in upper Egypt. Turk J Gastroenterol. 2014;25:707–13.CrossRefPubMed Morsy KH, Ghaliony MA, Mohammed HS. Outcomes and predictors of in-hospital mortality among cirrhotic patients with non-variceal upper gastrointestinal bleeding in upper Egypt. Turk J Gastroenterol. 2014;25:707–13.CrossRefPubMed
24.
go back to reference Jo Y, Choi J, Ha C, et al. The clinical features and prognostic factors of nonvariceal upper gastrointestinal bleeding in the patients with liver cirrhosis. Korean J Helicobacter Up Gastrointest Res. 2013;13:235–42.CrossRef Jo Y, Choi J, Ha C, et al. The clinical features and prognostic factors of nonvariceal upper gastrointestinal bleeding in the patients with liver cirrhosis. Korean J Helicobacter Up Gastrointest Res. 2013;13:235–42.CrossRef
Metadata
Title
Non-variceal upper gastrointestinal bleeding in cirrhotic patients in Nile Delta
Authors
Mamdouh Ahmed Gabr
Mohamed Abd El-Raouf Tawfik
Abd Allah Ahmed El-Sawy
Publication date
01-01-2016
Publisher
Springer India
Published in
Indian Journal of Gastroenterology / Issue 1/2016
Print ISSN: 0254-8860
Electronic ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-016-0622-7

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