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Published in: Indian Journal of Gastroenterology 6/2014

01-11-2014 | Editorial

Gut-liver axis and disease infidelity: A subject worth exploring

Authors: Prasenjit Das, Govind K. Makharia

Published in: Indian Journal of Gastroenterology | Issue 6/2014

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Excerpt

The spectrum of gluten-related disorders is widening and varies from celiac disease (CeD) to non-celiac gluten sensitivity [1]. While small intestine was thought to be the only organ involved in patients with CeD, it is now recognized that the hypersensitivity to gluten is not limited to the small intestine alone and may affect other organs such as skin, brain, and bones independent of intestinal involvement [25]. Dermatitis herpetiformis and gluten ataxia are the best example of such phenomena. …
Literature
2.
go back to reference Hadjivassiliou M, Sanders DS, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from gut to brain. Lancet Neurol. 2010;9:318–30.PubMedCrossRef Hadjivassiliou M, Sanders DS, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from gut to brain. Lancet Neurol. 2010;9:318–30.PubMedCrossRef
3.
go back to reference Antiga E, Caproni M, Pierini I, Bonciani D, Fabbri P. Gluten-free diet in patients with dermatitis herpetiformis: not only a matter of skin. Arch Dermatol. 2011;147:988–9.PubMedCrossRef Antiga E, Caproni M, Pierini I, Bonciani D, Fabbri P. Gluten-free diet in patients with dermatitis herpetiformis: not only a matter of skin. Arch Dermatol. 2011;147:988–9.PubMedCrossRef
4.
go back to reference Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology. 1992;102:330–54.PubMed Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology. 1992;102:330–54.PubMed
5.
go back to reference Makharia G. Where are Indian adult celiacs? Trop Gastroenterol. 2006;27:1–3.PubMed Makharia G. Where are Indian adult celiacs? Trop Gastroenterol. 2006;27:1–3.PubMed
6.
go back to reference Maiwall R, Goel A, Pulimood AB, et al. Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014;33:doi:10.1007/s12664-014-0501-z. Maiwall R, Goel A, Pulimood AB, et al. Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014;33:doi:10.​1007/​s12664-014-0501-z.
7.
go back to reference Trivedi PJ, Adams DH. The hepato-enteric immune axis in health and disease. Clinic Med. 2012;12:s74–8.CrossRef Trivedi PJ, Adams DH. The hepato-enteric immune axis in health and disease. Clinic Med. 2012;12:s74–8.CrossRef
8.
go back to reference Adams DH, Eksteen B, Curbishley SM. Immunology of the gut and liver: a love/hate relationship. Gut. 2008;57:838–48.PubMedCrossRef Adams DH, Eksteen B, Curbishley SM. Immunology of the gut and liver: a love/hate relationship. Gut. 2008;57:838–48.PubMedCrossRef
9.
go back to reference Sharma M, Singh P, Agnihotri A, et al. Celiac disease: a disease with varied manifestations in adults and adolescents. J Dig Dis. 2013;14:518–25.PubMedCrossRef Sharma M, Singh P, Agnihotri A, et al. Celiac disease: a disease with varied manifestations in adults and adolescents. J Dig Dis. 2013;14:518–25.PubMedCrossRef
10.
go back to reference Rostami-Nejad M, Haldane T, Aldulaimi D, Alavian SM, Zali MR, Rostami K. The role of celiac disease in severity of liver disorders and effect of a gluten free diet on diseases improvement. Hepat Mon. 2013;13:e11893.PubMedCentralPubMedCrossRef Rostami-Nejad M, Haldane T, Aldulaimi D, Alavian SM, Zali MR, Rostami K. The role of celiac disease in severity of liver disorders and effect of a gluten free diet on diseases improvement. Hepat Mon. 2013;13:e11893.PubMedCentralPubMedCrossRef
11.
go back to reference Rubio-Tapia A, Murray JA. The liver in celiac disease. Hepatol Baltim Md. 2007;46:1650–8.CrossRef Rubio-Tapia A, Murray JA. The liver in celiac disease. Hepatol Baltim Md. 2007;46:1650–8.CrossRef
12.
go back to reference Volta U, De Franceschi L, Lari F, Molinaro N, Zoli M, Bianchi FB. Coeliac disease hidden by cryptogenic hypertransaminasaemia. Lancet. 1998;352:26–9.PubMedCrossRef Volta U, De Franceschi L, Lari F, Molinaro N, Zoli M, Bianchi FB. Coeliac disease hidden by cryptogenic hypertransaminasaemia. Lancet. 1998;352:26–9.PubMedCrossRef
13.
go back to reference Volta U, De Franceschi L, Molinaro N, et al. Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatitis. Dig Dis Sci. 1998;43:2190–5.PubMedCrossRef Volta U, De Franceschi L, Molinaro N, et al. Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatitis. Dig Dis Sci. 1998;43:2190–5.PubMedCrossRef
14.
go back to reference Villalta D, Girolami D, Bidoli E, et al. High prevalence of celiac disease in autoimmune hepatitis detected by anti-tissue tranglutaminase autoantibodies. J Clin Lab Anal. 2005;19:6–10.PubMedCrossRef Villalta D, Girolami D, Bidoli E, et al. High prevalence of celiac disease in autoimmune hepatitis detected by anti-tissue tranglutaminase autoantibodies. J Clin Lab Anal. 2005;19:6–10.PubMedCrossRef
15.
go back to reference van Gerven NM, Bakker SF, de Boer YS, et al. On behalf of the Dutch AIH working group. Seroprevalence of celiac disease in patients with autoimmune hepatitis. Eur J Gastroenterol Hepatol. 2014;26:1104–7. van Gerven NM, Bakker SF, de Boer YS, et al. On behalf of the Dutch AIH working group. Seroprevalence of celiac disease in patients with autoimmune hepatitis. Eur J Gastroenterol Hepatol. 2014;26:1104–7.
16.
go back to reference Sorensen HT, Thulstrup AM, Blomqvist P, Nørgaard B, Fonager K, Ekbom A. Risk of primary biliary liver cirrhosis in patients with coeliac disease: Danish and Swedish cohort data. Gut. 1999;44:736–8.PubMedCentralPubMedCrossRef Sorensen HT, Thulstrup AM, Blomqvist P, Nørgaard B, Fonager K, Ekbom A. Risk of primary biliary liver cirrhosis in patients with coeliac disease: Danish and Swedish cohort data. Gut. 1999;44:736–8.PubMedCentralPubMedCrossRef
17.
go back to reference Ludvigsson JF, Elfström P, Broomé U, Ekbom A, Montgomery SM. Celiac disease and risk of liver disease: a general population-based study. Clin Gastroenterol Hepatol. 2007;5:63–9.PubMedCrossRef Ludvigsson JF, Elfström P, Broomé U, Ekbom A, Montgomery SM. Celiac disease and risk of liver disease: a general population-based study. Clin Gastroenterol Hepatol. 2007;5:63–9.PubMedCrossRef
18.
go back to reference Caprai S, Vajro P, Ventura A, Sciveres M, Maggiore G, SIGENP Study Group for Autoimmune Liver Disorders in Celiac Disease. Autoimmune liver disease associated with celiac disease in childhood: a multicenter study. Clin Gastroenterol Hepatol. 2008;6:803–6.PubMedCrossRef Caprai S, Vajro P, Ventura A, Sciveres M, Maggiore G, SIGENP Study Group for Autoimmune Liver Disorders in Celiac Disease. Autoimmune liver disease associated with celiac disease in childhood: a multicenter study. Clin Gastroenterol Hepatol. 2008;6:803–6.PubMedCrossRef
19.
go back to reference Singh P, Agnihotri A, Jindal G, et al. Celiac disease and chronic liver disease: is there a relationship? Indian J Gastroenterol. 2013;32:404–8.PubMedCrossRef Singh P, Agnihotri A, Jindal G, et al. Celiac disease and chronic liver disease: is there a relationship? Indian J Gastroenterol. 2013;32:404–8.PubMedCrossRef
20.
go back to reference Wakim-Fleming J, Pagadala MR, McCullough AJ, et al. Prevalence of celiac disease in cirrhosis and outcome of cirrhosis on a gluten free diet: a prospective study. J Hepatol. 2014;61:558–63.PubMedCrossRef Wakim-Fleming J, Pagadala MR, McCullough AJ, et al. Prevalence of celiac disease in cirrhosis and outcome of cirrhosis on a gluten free diet: a prospective study. J Hepatol. 2014;61:558–63.PubMedCrossRef
21.
go back to reference Lindgren S, Sjöberg K, Eriksson S. Unsuspected coeliac disease in chronic “cryptogenic” liver disease. Scand J Gastroenterol. 1994;29:661–4.PubMedCrossRef Lindgren S, Sjöberg K, Eriksson S. Unsuspected coeliac disease in chronic “cryptogenic” liver disease. Scand J Gastroenterol. 1994;29:661–4.PubMedCrossRef
22.
go back to reference Kaukinen K, Halme L, Collin P, et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology. 2002;122:881–8.PubMedCrossRef Kaukinen K, Halme L, Collin P, et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology. 2002;122:881–8.PubMedCrossRef
23.
25.
go back to reference Kochhar R, Masoodi I, Dutta U, et al. Celiac disease and Budd-Chiari syndrome: report of a case with review of literature. Eur J Gastroenterol Hepatol. 2009;21:1092–4.PubMedCrossRef Kochhar R, Masoodi I, Dutta U, et al. Celiac disease and Budd-Chiari syndrome: report of a case with review of literature. Eur J Gastroenterol Hepatol. 2009;21:1092–4.PubMedCrossRef
26.
go back to reference Hmami F, Chaouki S, Souilmi FZ, et al. Association of celiac disease and Budd-Chiari syndrome: a case report. Arch Pediatr. 2011;18:102.PubMedCrossRef Hmami F, Chaouki S, Souilmi FZ, et al. Association of celiac disease and Budd-Chiari syndrome: a case report. Arch Pediatr. 2011;18:102.PubMedCrossRef
27.
go back to reference Zamani F, Amiri A, Shakeri R, Zare A, Mohamadnejad M. Celiac disease as a potential cause of idiopathic portal hypertension: a case report. J Medical Case Reports. 2009;3:68.CrossRef Zamani F, Amiri A, Shakeri R, Zare A, Mohamadnejad M. Celiac disease as a potential cause of idiopathic portal hypertension: a case report. J Medical Case Reports. 2009;3:68.CrossRef
28.
go back to reference Sharma BC, Bhasin DK, Nada R. Association of celiac disease with non-cirrhotic portal fibrosis. J Gastroenterol Hepatol. 2006;21:332–4.PubMedCrossRef Sharma BC, Bhasin DK, Nada R. Association of celiac disease with non-cirrhotic portal fibrosis. J Gastroenterol Hepatol. 2006;21:332–4.PubMedCrossRef
29.
go back to reference Jacobsen MB, Fausa O, Elgjo K, Schrumpf E. Hepatic lesions in adult coeliac disease. Scand J Gastroenterol. 1990;25:656–62.PubMedCrossRef Jacobsen MB, Fausa O, Elgjo K, Schrumpf E. Hepatic lesions in adult coeliac disease. Scand J Gastroenterol. 1990;25:656–62.PubMedCrossRef
30.
go back to reference Wurbel MA, McIntire MG, Dwyer P, Fiebiger E. CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis. PLoS One. 2011;6:e16442.PubMedCentralPubMedCrossRef Wurbel MA, McIntire MG, Dwyer P, Fiebiger E. CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis. PLoS One. 2011;6:e16442.PubMedCentralPubMedCrossRef
31.
go back to reference Oo YH, Adams DH. The role of chemokines in the recruitment of lymphocytes to the liver. J Autoimmun. 2010;34:45–54.PubMedCrossRef Oo YH, Adams DH. The role of chemokines in the recruitment of lymphocytes to the liver. J Autoimmun. 2010;34:45–54.PubMedCrossRef
32.
go back to reference Adams DH, Eksteen B. Aberrant homing of mucosal T cells and extraintestinal manifestations of inflammatory bowel disease. Nat Rev Immunol. 2006;6:244–51.PubMedCrossRef Adams DH, Eksteen B. Aberrant homing of mucosal T cells and extraintestinal manifestations of inflammatory bowel disease. Nat Rev Immunol. 2006;6:244–51.PubMedCrossRef
Metadata
Title
Gut-liver axis and disease infidelity: A subject worth exploring
Authors
Prasenjit Das
Govind K. Makharia
Publication date
01-11-2014
Publisher
Springer India
Published in
Indian Journal of Gastroenterology / Issue 6/2014
Print ISSN: 0254-8860
Electronic ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-014-0503-x

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