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Journal of Maxillofacial and Oral Surgery

Published in:

01-09-2018 | Original Article

Epidemiology, Microbiology and Antibiotic Sensitivity of Odontogenic Space Infections in Central India

Authors: Neelam Shakya, Divashree Sharma, Vilas Newaskar, Deepak Agrawal, Sanket Shrivastava, Rashi Yadav

Published in: Journal of Maxillofacial and Oral Surgery | Issue 3/2018

Abstract

Introduction

Odontogenic infections are the most commonly encountered orofacial infections, which may spread into the adjacent anatomical spaces along the contiguous fascial planes, leading to involvement of multiple spaces which can progress to life-threatening situations.

Materials and Methods

A prospective study was carried out on 100 consecutive cases of odontogenic infections treated at our institute over a period of 18 months by surgical intervention and intravenous antibiotics. Morphologic study of the isolates and antibiotic sensitivity testing was performed.

Results

Caries was the most frequent dental disease (53.27%), and the mandibular first molar was the most frequently involved tooth (41.9%) associated with the etiology of odontogenic infections. A total of 158 spaces were involved in 100 patients. In subjects with single space odontogenic infections (n = 61), submandibular space was most commonly affected (44.26%) followed by buccal space (27%). In subjects with multiple space infections (n = 39), submandibular space (30.19%) was most frequently involved followed by buccal space (17.92%). In the aerobic group/microaerophilic group, 17 different species were isolated in a total of 102 aerobic isolates. A total of 18 species were identified in 65 anaerobic isolates sampled.

Conclusion

Amoxicillin possess antimicrobial activity against major pathogens in orofacial odontogenic infections, but β-lactamase production has restricted the effectiveness of amoxicillin against the resistant strains of Staphylococcus aureus, Bacteroides, Prevotella and Porphyromonas. For the management of orofacial infections, the use of amoxicillin/clavulanate and clindamycin is recommended because of stability against β-lactamases.

Hostetter MK (1990) Handicaps to host defense. Effects of hyperglycemia on C3 and Candida albicans. Diabetes 39:271–275CrossRefPubMed

Joshi N, Caputo GM, Weitekamp MR et al (1999) Infections in patients with diabetes mellitus. N Engl J Med 16(341):1906–1912CrossRef

Gill Y, Scully C (1990) Orofacial odontogenic infections: review of microbiology and current treatment. Oral Surg Oral Med Oral Pathol 70(2):155–158CrossRefPubMed

Ylijoki S, Suuronen R, Jousimies-Somer H, Meurman JH, Lindqvist C (2001) Differences between patients with or without the need for intensive care due to severe odontogenic infections. J Oral Maxillofac Surg 59(8):867–872 discussion 872-3 CrossRefPubMed

Mathew GC, Ranganathan LK, Gandhi S, Jacob ME, Singh I, Solanki M, Bither S (2012) Odontogenic maxillofacial space infections at a tertiary care center in North India: a five-year retrospective study. Int J Infect Dis 16(4):e296–e302CrossRefPubMed

Poeschl PW, Spusta L, Russmueller G, Seemann R, Hirschl A, Poeschl E, Klug C, Ewers R (2010) Antibiotic susceptibility and resistance of the odontogenic microbiological spectrum and its clinical impact on severe deep space head and neck infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(2):151–156CrossRefPubMed

Moenning JE, Nelson CL, Kohler RB (1989) The microbiology and chemotherapy of odontogenic infections. J Oral Maxillofac Surg 47(9):976–985CrossRefPubMed

Fating NS, Saikrishna D, Vijay Kumar GS, Shetty SK, Raghavendra Rao M (2014) Detection of bacterial flora in orofacial space infections and their antibiotic sensitivity profile. J Maxillofac Oral Surg. 13(4):525–532CrossRefPubMed

Flynn TR, Shanti RM, Levi MH, Adamo AK, Kraut RA, Trieger N (2006) Severe odontogenic infections, part 1: prospective report. J Oral Maxillofac Surg 64:1093–1103CrossRefPubMed

10.

Huang TT, Tseng FY, Liu TC, Hsu CJ, Chen YS (2005) Deep neck infection in diabetic patients: comparison of clinical picture and outcomes with nondiabeticpatients. Otolaryngol Head Neck Surg 132(6):943–947CrossRefPubMed

11.

Singh M, Kambalimath DH, Gupta KC (2014) Management of odontogenic space infection with microbiology study. J Maxillofac Oral Surg 13(2):133–139CrossRefPubMedPubMedCentral

12.

William Storoe, Richard Haug (2001) The changing face of odontogenic infections. J Oral Maxillofac Surg 59:739–748CrossRef

13.

Opitz D, Camerer C, Camerer DM, Raguse JD, Menneking H, Hoffmeister B, Adolphs N (2015) Incidence and management of severe odontogenic infections—a retrospective analysis from 2004 to 2011. J Craniomaxillofac Surg 43(2):285–289CrossRefPubMed

14.

Rega AJ, Aziz SR, Ziccardi VB (2006) Microbiology and antibiotic sensitivities of head and neck space infections of odontogenic origin. J Oral Maxillofac Surg 64:1377–1380CrossRefPubMed

15.

Haug RH, Hoffman MJ, Indresano AT (1991) An epidemiologic and anatomic survey of odontogenic infections. J Oral Maxillofac Surg 49(9):976–980CrossRefPubMed

16.

Jundt JS, Gutta R (2012) Characteristics and cost impact of severe odontogenic infections. Oral Surg Oral Med Oral Pathol Oral Radiol 114:558–566CrossRefPubMed

17.

Bali RK, Sharma P, Gaba S, Kaur A, Ghanghas P (2015) A review of complications of odontogenic infections. Natl J Maxillofac Surg 6(2):136–143CrossRefPubMedPubMedCentral

18.

Chunduri NS, Madasu K, Tammannavar PS, Pushpalatha C (2013) Necrotising fasciitis of odontogenic origin. BMJ Case Rep 2013:bcr2012008506CrossRefPubMedPubMedCentral

19.

Gams K, Freeman P (2016) Temporomandibular joint septic arthritis and mandibular osteomyelitis arising from an odontogenic infection: a case report and review of the literature. J Oral Maxillofac Surg 74(4):754–763CrossRefPubMed

20.

Cariati P, Cabello-Serrano A, Monsalve-Iglesias F, Roman-Ramos M, Garcia-Medina B (2016) Meningitis and subdural empyema as complication of pterygomandibular space abscess upon tooth extraction. J Clin Exp Dent. 8(4):e469–e472PubMedPubMedCentral

21.

Noy D, Rachmiel A, Levy-Faber D, Emodi O (2015) Lemierre’s syndrome from odontogenic infection: review of the literature and case description. Ann Maxillofac Surg 5(2):219–225CrossRefPubMedPubMedCentral

22.

Flynn TR (2011) What are the antibiotics of choice for odontogenic infections, and how long should the treatment course last? Oral Maxillofac Surg Clin North Am. 23(4):519–536CrossRefPubMed

23.

Krishnan V, Johnson JV, Helfrick JF (1993) Management of maxillofacial infections: a review of 50 cases. J Oral Maxillofac Surg 51(8):868–873CrossRefPubMed

24.

Aderhold L, Knothe H, Frenkel G (1981) The bacteriology of dentogenous pyogenic infections. Oral Surg Oral Med Oral Pathol. 52(6):583–587CrossRefPubMed

25.

Heimdahl A, von Konow L, Satoh T et al (1985) Clinical appearance of orofacial infections of odontogenic origin in relation to microbiological findings. J Clin Microbiol 22(2):299–302PubMedPubMedCentral

26.

Sakaguchi M, Sato S, Ishigama T, Katsuno S, Taguchi K (1997) Characteristics and management of deep neck infections. Int J Oral Maxillofac Surg 26:131–134CrossRefPubMed

27.

Sabiston CB, Grigsby WR, Segerstrom N (1976) Bacterial study of pyogenic infections of dental origin. Oral Surg Oral Med Oral Pathol 41(4):430–435CrossRefPubMed

28.

Kinder SA, Holt SC, Korman KS (1986) Penicillin resistance in subgingival microbiota associated with adult periodontitis. J Clin Microbiol 23(6):1127–1133PubMedPubMedCentral

29.

Von Konow L, Köndell PA, Nord CE, Heimdahl A (1992) Clindamycin versus phenoxymethylpenicillin in the treatment of acute orofacial infections. Eur J Clin Microbiol Infect Dis 11(12):1129–1135CrossRef

30.

Tancawan AL, Pato MN, Abidin KZ, Mohd Asari AS, Thong TX, Kochhar P et al (2015) Amoxicillin/clavulanic acid for the treatment of odontogenic infections: a randomised study comparing efficacy and tolerability versus clindamycin. Int J Dent 2015:472470CrossRefPubMedPubMedCentral

Title: Epidemiology, Microbiology and Antibiotic Sensitivity of Odontogenic Space Infections in Central India
Authors: Neelam Shakya
Divashree Sharma
Vilas Newaskar
Deepak Agrawal
Sanket Shrivastava
Rashi Yadav
Publication date: 01-09-2018
Publisher: Springer Singapore
Published in: Journal of Maxillofacial and Oral Surgery / Issue 3/2018
Print ISSN: 0972-8279
Electronic ISSN: 0974-942X
DOI: https://doi.org/10.1007/s12663-017-1014-y

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Epidemiology, Microbiology and Antibiotic Sensitivity of Odontogenic Space Infections in Central India

Abstract

Introduction

Materials and Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Materials and Methods

Results

Conclusion

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