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The journal of nutrition, health & aging

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01-06-2020 | Paget's Disease of Bone | Editorial

Old Bones

Author: John E. Morley

Published in: The journal of nutrition, health & aging | Issue 6/2020

Excerpt

Bone is a dynamic organ in which osteoblasts, under inhibitory control of sclerostin, creates new bone osteoblasts by releasing RANK-L to activate osteoclasts to remove bone. This dynamic network is under local control of miRNAs and long noncoding RNAs to balance the effect of bone stressors on bone formation (1). …

Zhou Y, Xu C, Zhu W, et al. Long noncoding RNA analyses for osteoporosis risk in Caucasian women. Calcif Tissue Int 2019;105:183–192.CrossRef

Morley JE. Hip fractures. J Am Med Dir Assoc 2010;11:81–83.CrossRef

Sanford AM, Morley JE, McKee A. Editorial: Orthogeriatrics and hip fractures. J Nutr Health Aging 2018;22:457–462.CrossRef

Devas MB. Geriatric Orthopaedics. Br Med J 1974;1(5900):190–192.CrossRef

Lefroy RB. Treatment of patients with fractured neck of the femur in a combined unit. Med J Aust 1980;2:669–670.CrossRef

Grigoryan KV, Javedan H, Rudolph JL. Orthogeriatric care models and outcomes in hip fracture patients: A systematic review and meta-analysis. J Orthop Trauma 2014;28:e49–55.CrossRef

Scurrah A, Shiner CT, stevens JA, Faux SG. Regional nerve blockade for early analgesic management of elderly patients with hip fracture — a narrative review. Anaesthesia. 2018;73:769–783.CrossRef

Howe JG, Hill RS, Stroncek JD, et al. Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: A long-term prospective cohort study. Osteoporos Int 2019;Dec 4 doi: https://doi.org/10.1007/s00198-019-05230-0 [Epub ahead of print]

Michou L, Orcel P. The changing countenance of Paget’s disease of bone. Joint Bone Spine 2016;83:650–655.CrossRef

10.

Sundaram K, Sambandam Y, Shanugarajan S, et al. Measles virus nucleocapsid protein modulates the signal regulatory protein-\gb1 (SIRP\gb1) to enhance osteoclast differentiation in Paget’s disease of bone. Bone Rep 2016;7:26–32.CrossRef

11.

Zimmerman L, McDeon B. Osteomalacia. StatPearls Publishing LLC. 2020. https://www.ncbi.nlm.nih.gov/pubmed/31869080

12.

McKee A, Lima Ribeiro SM, Malmstrom TK, et al. Screening for vitamin D deficiency in black Americans: Comparison of total, free, bioavailable 25 hydroxy vitamin D levels with parathyroid hormone levels and bone mineral density.

13.

Merchant RA, van Dam RM, Tan LWL, et al. Vitamin D binding protein and vitamin D level in multi-ethnic population. J Nutr Health Aging 2018;22:1060–1065.CrossRef

14.

Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med 2008;358:2355–2365.CrossRef

15.

Kanis JA, Harvey NC, Johansson H, et al. A decade of FRAX: How has it changed the management of osteoporosis? Aging clin Exp Res 2020;32:187–196.CrossRef

16.

Michaelssen K, Melhus H, Warensjo Lemming E, et al. Long term calcium intake and rates of all cause and cardiovascular mortality: Community based prospective longitudinal cohort study. BMJ 2013;346:f228.CrossRef

17.

Morley JE. Editorial: Vitamin D: Does the emperor have no clothes? J Nutr Health Aging 2019;23:316–317.CrossRef

18.

Minkin MJ. Menopause: ormones, lifestyle, and optimizing aging. Obstet Gynecol Clin North Am 2019;46:501–514.CrossRef

19.

Ettinger B, Black DM, Mitlak BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial. Multiple outcomes of raloxifene evaluation (MORE) investigato. JAMA 1999;282:637–645.CrossRef

20.

Black DM, Rosen CJ. Clinical practice. Postmenopausal osteoporosis. N Engl J Med 2016;374:254–262.CrossRef

21.

Black DM, Abrahamsen B, Bouxsein ML, et al. Atypical femur fractures; review of epidemiology, relationship to bisphosphonates, prevention, and clinical management. Endocr Rev 2019;40:333–368.CrossRef

22.

Dhillon S. Aclasta®): A review in osteoporosis. Drugs. 2016;76:1683–1697.CrossRef

23.

Deeks ED. Denosumab: A review in postmenopausal osteoporosis. Drugs Aging 2018;35:163–173.CrossRef

24.

Shi Z, Zhou H, Pan B, et al. Effectiveness of teriparatide on fracture healing: A systematic review and meta-analysis. PLoS One 2016;11(12):e0168691. Doi: https://doi.org/10.1371/journal.pone.0168691.eCollection2016.CrossRef

25.

Chen Q, Guo M, Ma X, et al. Adherence to teriparatide treatment and risk of fracture: A systematic review and meta-analysis. Horm Metab Res 2019;51:785–791. Doi: https://doi.org/10.1055/a-1062-9447.CrossRef

26.

Miller PD, Hattersley G, Rijs BJ, et al; ACTIVE Study Investigators. Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: A randomized clinical trial. JAMA 2016;316:722–733.CrossRef

27.

Saaq KG, Petersen J, Brandi ML, et al. Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med 2017;377:1417–1427.CrossRef

28.

Isidori AM, Giannetta E, Greco EA, et al. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: A metaanalysis.

29.

Snyder PJ, Peachey H, Hannoush P, et al. Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab 1999;84:2647–2653.PubMed

30.

Rouck JE, Malmstrom TK, Morley JE. Initial validation of the Toulouse — St. Louis University Mini Falls assessment in older adults. J Nutr Health Aging 2018;22:880–884.CrossRef

31.

Morley JE. F3ALLS approach to preventing falls. J Nutr Health Aging 2018;22:748–750.CrossRef

32.

Woo J, Yang X, Tin Lui L, et al. Utility of the FRAIL questionnaire in detecting heart failure with preserved ejection fraction. J Nutr Health Aging 2019;23:373–377.CrossRef

33.

Berry SD, Zullo AR, Zhang T, et al. Validation of the FRAIL model to predict nonvertebral and hip fractures in nursing home residents. Bone. 2019;128:115050. DOI: https://doi.org/10.1016/j.bone.2019.115050. Epub 2019 Aug 28.CrossRef

34.

Dent E, Morley JE, Cruz-Jentoft AJ, et al. Physical frailty: ICFSR international clinical practice guidelines for identification and management. J Nutr Health Aging 2019;23:771–787.CrossRef

35.

Dent E, Lien C, Lim WS, et al. The Asia-Pacific clinical practice guidelines for the management of frailty. J Am Med Dir Assoc 2017;18:564–575.CrossRef

36.

Morley JE. The new geriatric giants. Clin Geriatr Med 2017;33:xi–xii. Doi: https://doi.org/10.1016/j.cger.2017.05.001.CrossRef

37.

Dent E, Morley JE, CruzJentoft AJ, et al. International clinical practice guidelines for sarcopenia (ICFSR): Screening, diagnosis and management. J Nutr Health Aging 2018;22:1148–1161.CrossRef

38.

Ha YC, Won Won C, Kim M, et al. SARC-F as a useful tool for screening sarcopenia I elderly patients with hip fractures. J Nutr Health aging 2020;24:78–82.CrossRef

39.

Chen H, Ma J, Liu A, et al. The association between sarcopenia and fracture in middle-aged and elderly people: A systematic review and meta-analysis of cohort studies. Injury 2020;Feb 18 DOI: https://doi.org/10.1016/j.injury.2020.02.072 [Epub ahead of print].

Title: Old Bones
Author: John E. Morley
Publication date: 01-06-2020
Publisher: Springer Paris
Keywords: Paget's Disease of Bone
Osteomalacia
Osteoporosis
Osteoporosis
Osteomalacia
Zoledronic Acid
Published in: The journal of nutrition, health & aging / Issue 6/2020
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-020-1355-y

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