Top

The journal of nutrition, health & aging

Published in:

01-03-2020 | Sarcopenia

Relationship of Peripheral Lymphocyte Subsets and Skeletal Muscle Mass Index in Sarcopenia: A Cross-Sectional Study

Authors: S.-W. Huang, T. Xu, C.-T. Zhang, Hong-Lian Zhou

Published in: The journal of nutrition, health & aging | Issue 3/2020

Abstract

Objectives

Lymphocytes can affect the proliferation and migration of muscle satellite cells, which may be associated with reduced muscle mass in patients with sarcopenia. The present study aimed to further enrich understandings of the changes of blood lymphocytes and explore the relationship between peripheral lymphocyte subsets and muscle mass in patients with sarcopenia.

Design

A cross-sectional study.

Setting

Geriatrics department of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Methods

Eighty-five subjects were enrolled in this study, and were divided into two groups: the sarcopenia group (n=60) and the non-sarcopenia group (n=25). The diagnosis of sarcopenia was based on the diagnostic criteria updated by the Asian Working Group for Sarcopenia (AWGS) in 2014. Complete blood count, peripheral lymphocyte subsets, and body composition of all patients were measured.

Results

Skeletal muscle mass index (SMI) was negatively correlated with CD4⁺CD28^null T lymphocytes in peripheral blood in patients with sarcopenia.

Conclusion

The result of our study may point out the role of CD4+CD28^null T lymphocytes in the pathogenesis of sarcopenia.

Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and ageing 2019;48: 601–601. DOI: https://doi.org/10.1093/ageing/afz046 CrossRef

Bischoff-Ferrari HA, Orav JE, Kanis JA, et al. Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older. Osteoporosis International 2015;26: 2793–2802. DOI: https://doi.org/10.1007/s00198-015-3194-y CrossRef

Schaap LA, van Schoor NM, Lips P and Visser M. Associations of Sarcopenia Definitions, and Their Components, With the Incidence of Recurrent Falling and Fractures: The Longitudinal Aging Study Amsterdam. Journals of Gerontology Series a-Biological Sciences and Medical Sciences 2018;73: 1199–1204. DOI: https://doi.org/10.1093/gerona/glx245 CrossRef

Chang K-V, Hsu T-H, Wu W-T, Huang K-C and Han D-S. Association Between Sarcopenia and Cognitive Impairment: A Systematic Review and Meta-Analysis. Journal of the American Medical Directors Association 2016;17: DOI: https://doi.org/10.1016/j.jamda.2016.09.013 CrossRef

Arango-Lopera VE, Arroyo P, Gutierrez-Robledo LM, Perez-Zepeda MU and Cesari M. Mortality as an adverse outcome of sarcopenia. Journal of Nutrition Health & Aging 2013;17: 259–262. DOI: https://doi.org/10.1007/s12603-012-0434-0 CrossRef

Rolland Y, Czerwinski S, van Kan GA, et al. Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives. Journal of Nutrition Health & Aging 2008;12: 433–450. DOI: https://doi.org/10.1007/bf02982704 CrossRef

Chen B and Shan T. The role of satellite and other functional cell types in muscle repair and regeneration. Journal of Muscle Research and Cell Motility 2019;40: 1–8. DOI: https://doi.org/10.1007/s10974-019-09511-3 CrossRef

Zhang J, Xiao Z, Qu C, Cui W, Wang X and Du J. CD8 T Cells Are Involved in Skeletal Muscle Regeneration through Facilitating MCP-1 Secretion and Gr1(high) Macrophage Infiltration. Journal of Immunology 2014;193: 5149–5160. DOI: https://doi.org/10.4049/jimmunol.1303486 CrossRef

Schiaffino S, Pereira MG, Ciciliot S and Rovere-Querini P. Regulatory T cells and skeletal muscle regeneration. Febs Journal 2017;284: 517–524. DOI: https://doi.org/10.1111/febs.13827 CrossRef

10.

Al-Dabbagh S, McPhee JS, Murgatroyd C, Butler-Browne G, Stewart CE and Al-Shanti N. The lymphocyte secretome from young adults enhances skeletal muscle proliferation and migration, but effects are attenuated in the secretome of older adults. Physiological Reports 2015;3: DOI: https://doi.org/10.14814/phy2.12518 CrossRef

11.

Chen L-K, Lee W-J, Peng L-N, et al. Recent Advances in Sarcopenia Research in Asia: 2016 Update From the Asian Working Group for Sarcopenia. Journal of the American Medical Directors Association 2016;17: DOI: https://doi.org/10.1016/j.jamda.2016.05.016 CrossRef

12.

Liu L-K, Lee W-J, Liu C-L, et al. Age-related skeletal muscle mass loss and physical performance in Taiwan: Implications to diagnostic strategy of sarcopenia in Asia. Geriatrics & Gerontology International 2013;13: 964–971. DOI: https://doi.org/10.1111/ggi.12040 CrossRef

13.

Acuto O and Michel F. CD28-mediated co-stimulation: A quantitative support for TCR signalling. Nature Reviews Immunology 2003;3: 939–951. DOI: https://doi.org/10.1038/nri1248 CrossRef

14.

Dumitriu IE, %J Immunology. The life (and death) of CD4+ CD28(null) T cells in inflammatory diseases. 2015;146: 185–193.CrossRef

15.

Schmidt D, Martens PB, Weyand CM and Goronzy JJ. The repertoire of CD4+ CD28-T cells in rheumatoid arthritis. Molecular Medicine (Cambridge) 1996;2: 608–618. DOI: https://doi.org/10.1007/bf03401644 CrossRef

16.

Dumitriu IE, Baruah P, Finlayson CJ, et al. High Levels of Costimulatory Receptors OX40 and 4-1BB Characterize CD4(+)CD28(null) T Cells in Patients With Acute Coronary Syndrome. Circulation Research 2012;110: 857–U150. DOI: https://doi.org/10.1161/circresaha.111.261933 CrossRef

17.

Kovalcsik E, Antunes RF, Baruah P, Kaski JC and Dumitriu IE. Proteasome-Mediated Reduction in Proapoptotic Molecule Bim Renders CD4(+)CD28(null) T Cells Resistant to Apoptosis in Acute Coronary Syndrome. Circulation 2015;131: 709–U794. DOI: https://doi.org/10.1161/circulationaha.114.013710 CrossRef

18.

Weyand CM, Brandes JC, Schmidt D, Fulbright JW and Goronzy JJ. Functional properties of CD4(+)CD28(-) T cells in the aging immune system. Mechanisms of Ageing and Development 1998;102: 131–147. DOI: https://doi.org/10.1016/s0047-6374(97)00161-9 CrossRef

19.

van der Poel C, Gosselin LE, Schertzer JD, et al. Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury. J Inflamm-Lond 2011;8: 9. DOI: https://doi.org/10.1186/1476-9255-8-41 CrossRef

20.

Pedersen M, Bruunsgaard H, Weis N, et al. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mechanisms of Ageing and Development 2003;124: 495–502. DOI: https://doi.org/10.1016/s0047-6374(03)00027-7 CrossRef

21.

Li C-W, Yu K, Shyh-Chang N, et al. Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. Journal of Cachexia Sarcopenia and Muscle 2019;10: 586–600. DOI: https://doi.org/10.1002/jcsm.12417 CrossRef

22.

Fasth AER, Dastmalchi M, Rahbar A, et al. T Cell Infiltrates in the Muscles of Patients with Dermatomyositis and Polymyositis Are Dominated by CD28(null) T Cells. Journal of Immunology 2009;183: 4792–4799. DOI: https://doi.org/10.4049/jimmunol.0803688 CrossRef

Title: Relationship of Peripheral Lymphocyte Subsets and Skeletal Muscle Mass Index in Sarcopenia: A Cross-Sectional Study
Authors: S.-W. Huang
T. Xu
C.-T. Zhang
Hong-Lian Zhou
Publication date: 01-03-2020
Publisher: Springer Paris
Keyword: Sarcopenia
Published in: The journal of nutrition, health & aging / Issue 3/2020
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-020-1329-0

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Relationship of Peripheral Lymphocyte Subsets and Skeletal Muscle Mass Index in Sarcopenia: A Cross-Sectional Study

Abstract

Objectives

Design

Setting

Methods

Results

Conclusion

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Design

Setting

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 3/2020

Sarcopenia in Community-Dwelling Oldest Old is Associated with Disability and Poor Physical Function

Associations of TNF-Α −308 G>A and TNF-Β 252 A>G with Physical Function and BNP—Rugao Longevity and Ageing Study

Association Between Cognitive Function and Clustered Cardiovascular Risk of Metabolic Syndrome in Older Adults at Risk of Cognitive Decline

Combined Impact of Physical Frailty and Social Isolation on Rate of Falls in Older Adults

Loneliness in Old Age: An Unaddressed Health Problem

Phase Angle Reflects Loss of Functionality in Older Women

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page