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Netherlands Heart Journal
Published in: Netherlands Heart Journal 11/2015

Open Access 01-11-2015 | Original article

Platypnoea-orthodeoxia syndrome, an underdiagnosed cause of hypoxaemia: four cases and the possible underlying mechanisms

Authors: M. Nassif, H. Lu, T.C. Konings, B.J. Bouma, A. Vonk Noordegraaf, B. Straver, N.A. Blom, S.A. Clur, A.P.C.M. Backx, M. Groenink, S.M. Boekholdt, D.R. Koolbergen, M.G. Hazekamp, B.J.M. Mulder, R.J. de Winter

Published in: Netherlands Heart Journal | Issue 11/2015

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Abstract

Cardiac platypnoea-orthodeoxia syndrome (POS) is a position-dependent condition of dyspnoea and hypoxaemia due to right-to-left shunting. It often remains unrecognised in clinical practice, possibly because of its complex underlying pathophysiology. We present four consecutive patients with POS and patent foramen ovale (PFO) who underwent a successful percutaneous PFO closure, describe the mechanism of their POS and provide a review of the literature.
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Metadata
Title
Platypnoea-orthodeoxia syndrome, an underdiagnosed cause of hypoxaemia: four cases and the possible underlying mechanisms
Authors
M. Nassif
H. Lu
T.C. Konings
B.J. Bouma
A. Vonk Noordegraaf
B. Straver
N.A. Blom
S.A. Clur
A.P.C.M. Backx
M. Groenink
S.M. Boekholdt
D.R. Koolbergen
M.G. Hazekamp
B.J.M. Mulder
R.J. de Winter
Publication date
01-11-2015
Publisher
Bohn Stafleu van Loghum
Published in
Netherlands Heart Journal / Issue 11/2015
Print ISSN: 1568-5888
Electronic ISSN: 1876-6250
DOI
https://doi.org/10.1007/s12471-015-0714-5

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