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Published in: Netherlands Heart Journal 10/2011

Open Access 01-10-2011 | Original Article

Health care utilisation after defibrillator implantation for primary prevention according to the guidelines in 2 Dutch academic medical centres

Authors: T. Smith, P. F. van Dessel, D. A. M. J. Theuns, A. Muskens-Heemskerk, R. T. van Domburg, A. A. Wilde, L. Jordaens

Published in: Netherlands Heart Journal | Issue 10/2011

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Abstract

Background

The benefit of implantable defibrillators (ICDs) for primary prevention remains debated. We analysed the implications of prophylactic ICD implantation according to the guidelines in 2 tertiary hospitals, and made a healthcare utilisation inventory.

Methods

The cohort consisted of all consecutive patients with coronary artery disease (CAD) or dilated cardiomyopathy (DCM) receiving a primary prophylactic ICD in a contemporary setting (2004–2008). Follow-up was obtained from hospital databases, and mortality checked at the civil registry. Additional data came from questionnaires sent to general practitioners.

Results

There were no demographic differences between the 2 centres; one had proportionally more CAD patients and more resynchronisation therapy (CRT-D). The 587 patients were followed over a median of 28 months, and 50 (8.5%) patients died. Appropriate ICD intervention occurred in 123 patients (21%). There was a small difference in intervention-free survival between the 2 centres. The questionnaires revealed 338 hospital admissions in 52% of the responders. Device-related admissions happened on 68 occasions, in 49/276 responders. The most frequently reported ICD-related admission was due to shocks (20/49 patients); for other cardiac problems it was mainly heart failure (52/99). Additional outpatient visits occurred in 19%.

Conclusion

Over a median follow-up of 2 years, one fifth of prophylactic ICD patients receive appropriate interventions. A substantial group undergoes readmission and additional visits. The high number of admissions points to a very ill population. Overall mortality was 8.5%. The 2 centres employed a similar procedure with respect to patient selection. One centre used more CRT-D, and observed more appropriate ICD interventions.
Literature
1.
go back to reference Moss AJ, Hall WJ, Cannom DS, et al. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med. 1996;335:1933–40.PubMedCrossRef Moss AJ, Hall WJ, Cannom DS, et al. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med. 1996;335:1933–40.PubMedCrossRef
2.
go back to reference Moss AJ, Zareba W, Hall WJ, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346:877–83.PubMedCrossRef Moss AJ, Zareba W, Hall WJ, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346:877–83.PubMedCrossRef
3.
go back to reference Bardy GH, Lee KL, Mark DB, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–37.PubMedCrossRef Bardy GH, Lee KL, Mark DB, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–37.PubMedCrossRef
4.
go back to reference Zipes DP, Camm AJ, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Europace. 2006;8:746–837.PubMedCrossRef Zipes DP, Camm AJ, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Europace. 2006;8:746–837.PubMedCrossRef
5.
go back to reference Epstein AE, DiMarco JP, Ellenbogen KA, et al. ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalities: Executive Summary. Heart Rhythm. 2008;5:934–55.PubMedCrossRef Epstein AE, DiMarco JP, Ellenbogen KA, et al. ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalities: Executive Summary. Heart Rhythm. 2008;5:934–55.PubMedCrossRef
6.
go back to reference Strickberger SA, Hummel JD, Bartlett TG, et al. Amiodarone versus implantable cardioverter-defibrillator: randomized trial in patients with nonischemic dilated cardiomyopathy and asymptomatic nonsustained ventricular tachycardia–AMIOVIRT. J Am Coll Cardiol. 2003;41:1707–12.PubMedCrossRef Strickberger SA, Hummel JD, Bartlett TG, et al. Amiodarone versus implantable cardioverter-defibrillator: randomized trial in patients with nonischemic dilated cardiomyopathy and asymptomatic nonsustained ventricular tachycardia–AMIOVIRT. J Am Coll Cardiol. 2003;41:1707–12.PubMedCrossRef
7.
go back to reference Bänsch D, Antz M, Boczor S, et al. Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT). Circulation. 2002;105:1453–8.PubMedCrossRef Bänsch D, Antz M, Boczor S, et al. Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT). Circulation. 2002;105:1453–8.PubMedCrossRef
8.
go back to reference Kadish A, Dyer A, Daubert JP, et al. Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med. 2004;350:2151–8.PubMedCrossRef Kadish A, Dyer A, Daubert JP, et al. Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med. 2004;350:2151–8.PubMedCrossRef
9.
go back to reference Desai AS, Fang JC, Maisel WH, et al. Implantable defibrillators for the prevention of mortality in patients with nonischemic cardiomyopathy: a meta-analysis of randomized controlled trials. JAMA. 2004;292:2874–9.PubMedCrossRef Desai AS, Fang JC, Maisel WH, et al. Implantable defibrillators for the prevention of mortality in patients with nonischemic cardiomyopathy: a meta-analysis of randomized controlled trials. JAMA. 2004;292:2874–9.PubMedCrossRef
10.
go back to reference Theuns DAMJ, Smith T, Hunink MGM, et al. Effectiveness of prophylactic implantation of cardioverter-defibrillators without cardiac resynchronisation in patients with ischaemic or nonischaemic heart disease: a systematic review and meta-analysis. Europace. 2010;12:1564–70.PubMedCrossRef Theuns DAMJ, Smith T, Hunink MGM, et al. Effectiveness of prophylactic implantation of cardioverter-defibrillators without cardiac resynchronisation in patients with ischaemic or nonischaemic heart disease: a systematic review and meta-analysis. Europace. 2010;12:1564–70.PubMedCrossRef
11.
go back to reference Sanders GD, Hlatky MA, Owens DK. Cost-effectiveness of implantable cardioverter-defibrillators. N Engl J Med. 2005;353:1471–80.PubMedCrossRef Sanders GD, Hlatky MA, Owens DK. Cost-effectiveness of implantable cardioverter-defibrillators. N Engl J Med. 2005;353:1471–80.PubMedCrossRef
12.
go back to reference Zwanziger J, Hall J, Dick AW, et al. The cost effectiveness of implantable cardioverter-defibrillators. Results from the multicenter automatic defibrillator implantation trial (MADIT)-II. JACC. 2006;47:2310–8.PubMed Zwanziger J, Hall J, Dick AW, et al. The cost effectiveness of implantable cardioverter-defibrillators. Results from the multicenter automatic defibrillator implantation trial (MADIT)-II. JACC. 2006;47:2310–8.PubMed
13.
go back to reference Mark DB, Nelson CL, Anstrom KJ, et al. Cost-effectiveness of defibrillator therapy or Amiodarone in chronic stable heart failure. Circulation. 2006;114:135–42.PubMedCrossRef Mark DB, Nelson CL, Anstrom KJ, et al. Cost-effectiveness of defibrillator therapy or Amiodarone in chronic stable heart failure. Circulation. 2006;114:135–42.PubMedCrossRef
14.
go back to reference Caro JJ, Ward A, Deniz HB, et al. Cost-benefit analysis of preventing sudden cardiac deaths with an implantable cardioverter defibrillator versus Amiodarone. Value Health. 2007;10:13–22.PubMedCrossRef Caro JJ, Ward A, Deniz HB, et al. Cost-benefit analysis of preventing sudden cardiac deaths with an implantable cardioverter defibrillator versus Amiodarone. Value Health. 2007;10:13–22.PubMedCrossRef
15.
go back to reference Cowie MR, Marshall D, Drummond M, et al. Lifetime cost-effectiveness of prophylactic implantation of a cardioverter defibrillator in patients with reduced left ventricular systolic function: results of Markov modelling in a European population. Europace. 2009;11:716–26.PubMedCrossRef Cowie MR, Marshall D, Drummond M, et al. Lifetime cost-effectiveness of prophylactic implantation of a cardioverter defibrillator in patients with reduced left ventricular systolic function: results of Markov modelling in a European population. Europace. 2009;11:716–26.PubMedCrossRef
16.
go back to reference Neyt M, Thiry N, Ramaekers D, et al. Cost effectiveness of implantable cardioverter-defibrillators for primary prevention in a Belgian context. Appl Health Econ Health Policy. 2008;6:67–80.PubMedCrossRef Neyt M, Thiry N, Ramaekers D, et al. Cost effectiveness of implantable cardioverter-defibrillators for primary prevention in a Belgian context. Appl Health Econ Health Policy. 2008;6:67–80.PubMedCrossRef
17.
go back to reference Van Brabandt H, Neyt M. Pitfalls in health-economic evaluations: the case of cost-effectiveness of prophylactic implantable cardioverter-defibrillator therapy in Belgium. Europace. 2009;11:1571–3.PubMedCrossRef Van Brabandt H, Neyt M. Pitfalls in health-economic evaluations: the case of cost-effectiveness of prophylactic implantable cardioverter-defibrillator therapy in Belgium. Europace. 2009;11:1571–3.PubMedCrossRef
18.
go back to reference Hauser RG. The growing mismatch between patient longevity and the service life of implantable cardioverter-defibrillators. J Am Coll Cardiol. 2005;45:2022–5.PubMedCrossRef Hauser RG. The growing mismatch between patient longevity and the service life of implantable cardioverter-defibrillators. J Am Coll Cardiol. 2005;45:2022–5.PubMedCrossRef
19.
go back to reference Maisel WH, Moynahan M, Zuckerman BD, et al. Pacemaker and ICD generator malfunctions: analysis of Food and Drug Administration annual reports. JAMA. 2006;295:1901–6.PubMedCrossRef Maisel WH, Moynahan M, Zuckerman BD, et al. Pacemaker and ICD generator malfunctions: analysis of Food and Drug Administration annual reports. JAMA. 2006;295:1901–6.PubMedCrossRef
20.
go back to reference Kleemann T, Becker T, Doenges K, et al. Annual rate of transvenous defibrillation lead defects in implantable cardioverter-defibrillators over a period of >10 years. Circulation. 2007;115:2474–80.PubMedCrossRef Kleemann T, Becker T, Doenges K, et al. Annual rate of transvenous defibrillation lead defects in implantable cardioverter-defibrillators over a period of >10 years. Circulation. 2007;115:2474–80.PubMedCrossRef
21.
go back to reference Maisel WH, Kramer DB. Implantable cardioverter-defibrillator lead performance. Circulation. 2008;117:2721–3.PubMedCrossRef Maisel WH, Kramer DB. Implantable cardioverter-defibrillator lead performance. Circulation. 2008;117:2721–3.PubMedCrossRef
22.
go back to reference Hauser RG, Hayes DL. Increasing hazard of Sprint Fidelis implantable cardioverter-defibrillator lead failure. Heart Rhythm. 2009;6:605–10.PubMedCrossRef Hauser RG, Hayes DL. Increasing hazard of Sprint Fidelis implantable cardioverter-defibrillator lead failure. Heart Rhythm. 2009;6:605–10.PubMedCrossRef
23.
go back to reference Borleffs C, Wilde A, Cramer J, et al. Clinical implementation of guidelines for cardioverter defibrillation implantation: lost in translation? Neth Heart J. 2007;15:129–32.PubMedCrossRef Borleffs C, Wilde A, Cramer J, et al. Clinical implementation of guidelines for cardioverter defibrillation implantation: lost in translation? Neth Heart J. 2007;15:129–32.PubMedCrossRef
24.
go back to reference Camm AJ, Nisam S. European utilization of the implantable defibrillator: has 10 years changed the ‘enigma’? Europace. 2010;12:1063–9.CrossRef Camm AJ, Nisam S. European utilization of the implantable defibrillator: has 10 years changed the ‘enigma’? Europace. 2010;12:1063–9.CrossRef
25.
go back to reference Camm J, Klein H, Nisam S. The cost of implantable defibrillators: perceptions and reality. Eur Heart J. 2007;28:392–7.PubMedCrossRef Camm J, Klein H, Nisam S. The cost of implantable defibrillators: perceptions and reality. Eur Heart J. 2007;28:392–7.PubMedCrossRef
26.
27.
go back to reference Santini M, Russo M, Botto G, et al. Clinical and arrhythmic outcomes after implantation of a defibrillator for primary prevention of sudden death in patients with post-myocardial infarction cardiomyopathy: The Survey to Evaluate Arrhythmia Rate in High-risk MI patients (SEARCH-MI). Europace. 2009;11:476–82.PubMedCrossRef Santini M, Russo M, Botto G, et al. Clinical and arrhythmic outcomes after implantation of a defibrillator for primary prevention of sudden death in patients with post-myocardial infarction cardiomyopathy: The Survey to Evaluate Arrhythmia Rate in High-risk MI patients (SEARCH-MI). Europace. 2009;11:476–82.PubMedCrossRef
28.
go back to reference Gradaus R, Block M, Brachmann J, et al. Mortality, morbidity, and complications in 3344 patients with implantable cardioverter defibrillators: results fron the German ICD Registry EURID. Pacing Clin Electrophysiol. 2003;26:1511–8.PubMedCrossRef Gradaus R, Block M, Brachmann J, et al. Mortality, morbidity, and complications in 3344 patients with implantable cardioverter defibrillators: results fron the German ICD Registry EURID. Pacing Clin Electrophysiol. 2003;26:1511–8.PubMedCrossRef
29.
go back to reference Hohnloser SH, Kuck KH, Dorian P, et al. Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction. N Engl J Med. 2004;351:2481–8.PubMedCrossRef Hohnloser SH, Kuck KH, Dorian P, et al. Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction. N Engl J Med. 2004;351:2481–8.PubMedCrossRef
30.
go back to reference Steinbeck G, Andresen D, Seidl K, et al. Defibrillator implantation early after myocardial infarction. N Engl J Med. 2009;361:1427–36.PubMedCrossRef Steinbeck G, Andresen D, Seidl K, et al. Defibrillator implantation early after myocardial infarction. N Engl J Med. 2009;361:1427–36.PubMedCrossRef
31.
go back to reference Wathen MS, DeGroot PJ, Sweeney MO, et al. PainFREE Rx II Investigators. Prospective randomized multicenter trial of empirical antitachycardia pacing versus shocks for spontaneous rapid ventricular tachycardia in patients with implantable cardioverter-defibrillators: Pacing Fast Ventricular Tachycardia Reduces Shock Therapies (PainFREE Rx II) trial results. Circulation. 2004;110:2591–6.PubMedCrossRef Wathen MS, DeGroot PJ, Sweeney MO, et al. PainFREE Rx II Investigators. Prospective randomized multicenter trial of empirical antitachycardia pacing versus shocks for spontaneous rapid ventricular tachycardia in patients with implantable cardioverter-defibrillators: Pacing Fast Ventricular Tachycardia Reduces Shock Therapies (PainFREE Rx II) trial results. Circulation. 2004;110:2591–6.PubMedCrossRef
32.
go back to reference Theuns DA, Rivero-Ayerza M, Goedhart DM, et al. Morphology discrimination in implantable cardioverter-defibrillators: consistency of template match percentage during atrial tachyarrhythmias at different heart rates. Europace. 2008;10:1060–6.PubMedCrossRef Theuns DA, Rivero-Ayerza M, Goedhart DM, et al. Morphology discrimination in implantable cardioverter-defibrillators: consistency of template match percentage during atrial tachyarrhythmias at different heart rates. Europace. 2008;10:1060–6.PubMedCrossRef
33.
go back to reference Pellegrini CN, Lee K, Olgin JE, et al. Impact of advanced age on survival in patients with implantable cardioverter defibrillators. Europace. 2008;10:1296–301.PubMedCrossRef Pellegrini CN, Lee K, Olgin JE, et al. Impact of advanced age on survival in patients with implantable cardioverter defibrillators. Europace. 2008;10:1296–301.PubMedCrossRef
34.
go back to reference Cygankiewicz I, Gillespie J, Zareba W, et al. Predictors of long-term mortality in Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) patients with implantable cardioverter-defibrillators. Heart Rhythm. 2009;6:468–73.PubMedCrossRef Cygankiewicz I, Gillespie J, Zareba W, et al. Predictors of long-term mortality in Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) patients with implantable cardioverter-defibrillators. Heart Rhythm. 2009;6:468–73.PubMedCrossRef
35.
go back to reference Theuns DAMJ, Schaer B, Soliman OII, et al. The prognosis of implantable defibrillator patients treated with cardiac resynchronization therapy: comorbidity burden as predictor of mortality. Europace. 2011;13:62–9.PubMedCrossRef Theuns DAMJ, Schaer B, Soliman OII, et al. The prognosis of implantable defibrillator patients treated with cardiac resynchronization therapy: comorbidity burden as predictor of mortality. Europace. 2011;13:62–9.PubMedCrossRef
36.
go back to reference Al-Khatib SM, Lucas FL, Jollis JG, et al. The relation between patients’ outcomes and the volume of cardioverter-defibrillator implantation procedures performed by physicians treating Medicare beneficiaries. J Am Coll Cardiol. 2005;46:1536–40.PubMedCrossRef Al-Khatib SM, Lucas FL, Jollis JG, et al. The relation between patients’ outcomes and the volume of cardioverter-defibrillator implantation procedures performed by physicians treating Medicare beneficiaries. J Am Coll Cardiol. 2005;46:1536–40.PubMedCrossRef
37.
go back to reference Curtis JP, Luebbert JJ, Wang Y, et al. Association of physician certification and outcomes among patients receiving an implantable cardioverter-defibrillator. JAMA. 2009;301:1661–70.PubMedCrossRef Curtis JP, Luebbert JJ, Wang Y, et al. Association of physician certification and outcomes among patients receiving an implantable cardioverter-defibrillator. JAMA. 2009;301:1661–70.PubMedCrossRef
38.
go back to reference Moss AJ, Greenberg H, Case RB, et al. Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator. Circulation. 2004;110:3760–5.PubMedCrossRef Moss AJ, Greenberg H, Case RB, et al. Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator. Circulation. 2004;110:3760–5.PubMedCrossRef
39.
go back to reference Goldenberg I, Moss AJ, Hall WJ, et al. Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II. Circulation. 2006;113:2810–7.PubMedCrossRef Goldenberg I, Moss AJ, Hall WJ, et al. Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II. Circulation. 2006;113:2810–7.PubMedCrossRef
Metadata
Title
Health care utilisation after defibrillator implantation for primary prevention according to the guidelines in 2 Dutch academic medical centres
Authors
T. Smith
P. F. van Dessel
D. A. M. J. Theuns
A. Muskens-Heemskerk
R. T. van Domburg
A. A. Wilde
L. Jordaens
Publication date
01-10-2011
Publisher
Bohn Stafleu van Loghum
Published in
Netherlands Heart Journal / Issue 10/2011
Print ISSN: 1568-5888
Electronic ISSN: 1876-6250
DOI
https://doi.org/10.1007/s12471-011-0176-3

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