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Current Cardiovascular Imaging Reports
Published in: Current Cardiovascular Imaging Reports 4/2012

01-08-2012 | Intravascular Imaging (U Landmesser, Section Editor)

How Do OCT and IVUS Compare to Histology in Coronary Atherosclerosis and Stenting?

Authors: Fumiyuki Otsuka, Masataka Nakano, Frank D. Kolodgie, Renu Virmani

Published in: Current Cardiovascular Imaging Reports | Issue 4/2012

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Abstract

Recent advances in intra-coronary imaging modalities have enabled us to evaluate precise plaque morphologies and vascular response to coronary stents in vivo. Superior resolution of optical coherence tomography (OCT) allows the measurement of fibrous cap thickness and detection of macrophage accumulation, both of which are critical to identify vulnerable plaques. Poor penetration of OCT however limits the assessment of plaque volume and vessel remodeling, while intravascular ultrasound (IVUS) is capable of evaluating these parameters. Caution must be exercised when interpreting IVUS-based tissue characterization because this technology lacks sufficient resolution to evaluate plaque composition. In stented arteries, OCT has the ability to detect uncovered struts and abnormal neointimal tissues including fibrin deposition, inflammation (hypersensitivity), and neoatherosclerosis, especially following drug-eluting stent placement. These findings suggest a potential clinical benefit of OCT to assess the risk of future adverse cardiac events; at the same time understanding the limitation of this technology is also important.
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Metadata
Title
How Do OCT and IVUS Compare to Histology in Coronary Atherosclerosis and Stenting?
Authors
Fumiyuki Otsuka
Masataka Nakano
Frank D. Kolodgie
Renu Virmani
Publication date
01-08-2012
Publisher
Current Science Inc.
Published in
Current Cardiovascular Imaging Reports / Issue 4/2012
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-012-9144-6

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