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Open Access 01-12-2019 | Heart Failure | Review Article

Phase analysis of gated PET in the evaluation of mechanical ventricular synchrony: A narrative overview

Authors: Luis Eduardo Juarez-Orozco, MD, PhD, Andrea Monroy-Gonzalez, MD, Niek H. J. Prakken, MD, PhD, Walter Noordzij, MD, PhD, Juhani Knuuti, MD, PhD, Robert A. deKemp, PhD, Riemer H. J. A. Slart, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 6/2019

Abstract

Noninvasive imaging modalities offer the possibility to dynamically evaluate cardiac motion during the cardiac cycle by means of ECG-gated acquisitions. Such motion characterization along with orientation, segmentation preprocessing, and ultimately, phase analysis, can provide quantitative estimates of ventricular mechanical synchrony. Current evidence on the role of mechanical synchrony evaluation is mainly available for echocardiography and gated single-photon emission computed tomography, but less is known about the utilization of gated positron emission tomography (PET). Although data available are sparse, there is indication that mechanical synchrony evaluation can be of diagnostic and prognostic values in patients with known or suspected coronary artery disease-related myocardial ischemia, prediction of response to cardiac resynchronization therapy, and estimation of risk for adverse cardiac events in patients’ heart failure. As such, the evaluation of mechanical ventricular synchrony through phase analysis of gated acquisitions represents a value addition to modern cardiac PET imaging modality, which warrants further research and development in the evaluation of patients with cardiovascular disease.

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Title: Phase analysis of gated PET in the evaluation of mechanical ventricular synchrony: A narrative overview
Authors: Luis Eduardo Juarez-Orozco, MD, PhD
Andrea Monroy-Gonzalez, MD
Niek H. J. Prakken, MD, PhD
Walter Noordzij, MD, PhD
Juhani Knuuti, MD, PhD
Robert A. deKemp, PhD
Riemer H. J. A. Slart, MD, PhD
Publication date: 01-12-2019
Publisher: Springer International Publishing
Keywords: Heart Failure
Positron Emission Tomography
Cardiac Resynchronization Therapy
Cardiac Resynchronization Therapy
Cardiac Resynchronization Therapy
Cardiac Resynchronization Therapy
Published in: Journal of Nuclear Cardiology / Issue 6/2019
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-019-01670-7

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