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Published in: Journal of Nuclear Cardiology 2/2019

01-04-2019 | Original Article

FDG PET-CT findings of extra-thoracic sarcoid are associated with cardiac sarcoid: A rationale for using FGD PET-CT for cardiac sarcoid evaluation

Authors: Darshan C. Patel, MD, MPH, Senthil S. Gunasekaran, MD, Christopher Goettl, MD, Nadera J. Sweiss, MD, Yang Lu, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 2/2019

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Abstract

Purpose

This retrospective study investigates the relationship between cardiac and extra-thoracic sarcoid findings on FDG PET-CT using a 72-hour pretest high-fat, high-protein, and very low-carbohydrate (HFHPVLC) diet.

Patients and methods

A total of 196 consecutive FDG PET-CT scans with 72-hour HFHPVLC diet preparation were performed between December 2014 and December 2015 in known sarcoid patients. Of these scans, 5 were excluded for non-adherence to diet preparation or underlying cancer. Cardiac and extra-thoracic sarcoid lesions were categorized and measured for radiotracer uptake.

Results

A total of 188 patients had 191 eligible FDG PET/CT scans (3 follow-up scans), of which there were 20 (10%) positive, 6 indeterminate (3%), and 165 (86%) negative for CS. Among the 20 scans positive for CS, 8 (40%) had findings of both cardiac and extra-thoracic sarcoid.

Conclusion

Our study shows that 40% of CS patients also have FDG PET-CT findings of extra-thoracic sarcoid. This makes an intriguing case for FDG PET-CT use with pretest diet prep over cardiac MRI (CMR) for cardiac sarcoid evaluation, given that CMR is likely to overlook these extra-thoracic sites of disease.
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Metadata
Title
FDG PET-CT findings of extra-thoracic sarcoid are associated with cardiac sarcoid: A rationale for using FGD PET-CT for cardiac sarcoid evaluation
Authors
Darshan C. Patel, MD, MPH
Senthil S. Gunasekaran, MD
Christopher Goettl, MD
Nadera J. Sweiss, MD
Yang Lu, MD, PhD
Publication date
01-04-2019
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 2/2019
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-017-0962-4

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