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Journal of Nuclear Cardiology

Published in:

01-06-2018 | Original Article

Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging

Authors: Masaru Ishihara, MS, Yasuyo Taniguchi, MD, Masahisa Onoguchi, PhD, Takayuki Shibutani, MS

Published in: Journal of Nuclear Cardiology | Issue 3/2018

Abstract

Background

We aimed to determine the optimal thallium 201 chloride (thallium-201) dose using a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors (D-SPECT).

Methods and Results

The optimal thallium-201 dose for obtaining left ventricular (LV) myocardial counts was determined from a phantom study. Consecutive 292 patients underwent stress myocardial perfusion imaging with a thallium-201 injection. Stress test comprised exercise or pharmacological (adenosine) provocation. We calculated an optimal thallium-201 dose that resulted in better LV myocardial counts during 6 minutes of acquisition time. We corrected the respective values according to the patient’s age, sex, body mass index (BMI), and type of stress test. The lowest thallium-201 dose for obtaining acceptable imaging was 1.2 million counts. Radiopharmaceutical doses showed a positive correlation with the patient’s age (P < .001), sex (P = .012), BMI (P < .001), and type of stress test (P < .001). Multivariate analysis revealed that the patient’s BMI and the type of stress test were statistically significant factors for determining the correct radiopharmaceutical dose (P < .001 for both).

Conclusions

For clinical use of the CZT SPECT system, the optimal individual thallium-201 doses can be determined based on the patient’s BMI and type of stress test.

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Title: Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging
Authors: Masaru Ishihara, MS
Yasuyo Taniguchi, MD
Masahisa Onoguchi, PhD
Takayuki Shibutani, MS
Publication date: 01-06-2018
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 3/2018
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0749-z

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Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging

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Methods and Results

Conclusions

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