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01-08-2017 | Editorial

Sex difference in cardiac metabolism in nonischemic heart failure: Insight for prognostic value of altered cardiac metabolism

Authors: Hyung-Jun Im, MD, PhD, Gi Jeong Cheon, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 4/2017

Excerpt

Heart has the highest metabolic demands than any other organs. To maintain contractile function of the heart, constant and rapid production of adenosine triphosphate (ATP) is needed. Fatty acid (FA) and glucose are the main fuels for production of the ATPs by mitochondrial oxidative phosphorylation. In normal condition, 60% to 90% of total ATP is made from FA and the other from glucose or lactate. In a failing heart, cardiac metabolism is profoundly altered, and majority of the studies suggest that FA metabolism decreases. However, it is not clear and still in controversy whether the alteration in cardiac metabolism in a failing heart is an adaptation or maladaptation.1‐3 …

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Title: Sex difference in cardiac metabolism in nonischemic heart failure: Insight for prognostic value of altered cardiac metabolism
Authors: Hyung-Jun Im, MD, PhD
Gi Jeong Cheon, MD, PhD
Publication date: 01-08-2017
Publisher: Springer International Publishing
Published in: Journal of Nuclear Cardiology / Issue 4/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0489-0

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