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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 3/2013

Open Access 01-06-2013 | Original Article

Coronary artery and thoracic aorta calcification is inversely related to coronary flow reserve as measured by 82Rb PET/CT in intermediate risk patients

Authors: Jongho Kim, MD, PhD, Paco E. Bravo, MD, Ali Gholamrezanezhad, MD, Seil Sohn, MD, Ash Rafique, CNMT, Arlene Travis, MS, Josef Machac, MD

Published in: Journal of Nuclear Cardiology | Issue 3/2013

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Abstract

Background

The strength and nature of the relationship between myocardial perfusion imaging (MPI), coronary flow reserve (CFR), and coronary artery calcium (CAC) and thoracic aorta calcium (TAC) remain to be clarified.

Methods

Dynamic rest-pharmacological stress 82Rb positron emission tomography/computed tomography MPI with CFR, CAC, and TAC was performed in 75 patients (59 ± 13 years; F/M = 38/37) with intermediate risk of coronary artery disease.

Results

A total of 29 (39%) patients had ischemic and 46 (61%) had normal MPI. CAC was correlated with TAC (ρ = 0.7; P < .001), and CFR was inversely related with CAC and TAC (ρ = −0.6 and −0.5; P < .001, respectively). By gender-specific univariate analysis, age (P = .001), CAC (P = .004), and CFR (P = .008) in males, but CFR (P = .0001), age (P = .002), and TAC (P = .01) in females were significant predictors of ischemic MPI. By multiple regression, the most potent predictor was CFR [odds ratio (OR) = 0.17, P = .01), followed by age (OR = 1.07, P = .02), gender (OR = 4.01, P = .03), and CAC (OR = 1.002, P = .9).

Conclusions

Combination of MPI, CFR, CAC, and TAC has complementary roles in intermediate risk patients.
Appendix
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Metadata
Title
Coronary artery and thoracic aorta calcification is inversely related to coronary flow reserve as measured by 82Rb PET/CT in intermediate risk patients
Authors
Jongho Kim, MD, PhD
Paco E. Bravo, MD
Ali Gholamrezanezhad, MD
Seil Sohn, MD
Ash Rafique, CNMT
Arlene Travis, MS
Josef Machac, MD
Publication date
01-06-2013
Publisher
Springer US
Published in
Journal of Nuclear Cardiology / Issue 3/2013
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-013-9675-5

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