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01-02-2013 | Original Article

Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera

Authors: Jenny Oddstig, PhD, Fredrik Hedeer, MD, Jonas Jögi, MD, PhD, Marcus Carlsson, MD, PhD, Cecilia Hindorf, PhD, Henrik Engblom, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 1/2013

Abstract

Background

For a 1-day myocardial perfusion SPECT (MPS) the recommendations for administered activity stated in the EANM guidelines results in an effective dose of up to 16 mSv per patient. Recently, a gamma camera system, based on cadmium zinc telluride (CZT) technology, was introduced. This technique has the potential to reduce the effective dose and scan time compared to the conventional NaI gamma camera. The aim of this study was to investigate if the effective dose can be reduced with a preserved image quality using CZT technology in MPS.

Methods

In total, 150 patients were included in the study. All underwent a 1-day ^99mTc-tetrofosmin stress-rest protocol and were divided into three subgroups (n = 50 in each group) with 4, 3, and 2.5 MBq/kg body weight of administered activity in the stress examination, respectively. The acquisition time was increased in proportion to the decrease in administered activity. All examinations were analyzed for image quality by visual grading on a 4-point scale (1 = poor, 2 = adequate, 3 = good, 4 = excellent), by two expert readers.

Results

The total effective dose (stress + rest) decreased from 9.3 to 5.8 mSv comparing 4 to 2.5 MBq/kg body weight. For the patients undergoing stress examination only (35%) the effective dose, administrating 2.5 MBq/kg, was 1.4 mSv. The image acquisition times for 2.5 MBq/kg body weight were 475 and 300 seconds (stress and rest) compared to 900 seconds for each when using conventional MPS. The average image quality was 3.7 ± 0.5, 3.8 ± 0.5, and 3.8 ± 0.4 for the stress images and 3.5 ± 0.6, 3.6 ± 0.6, and 3.5 ± 0.6 for the rest images and showed no statistically significant difference (P = .62) among the 4, 3, and 2.5 MBq/kg groups.

Conclusions

The new CZT technology can be used to considerably decrease the effective dose and acquisition time for MPS with preserved high image quality.

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Title: Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera
Authors: Jenny Oddstig, PhD
Fredrik Hedeer, MD
Jonas Jögi, MD, PhD
Marcus Carlsson, MD, PhD
Cecilia Hindorf, PhD
Henrik Engblom, MD, PhD
Publication date: 01-02-2013
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 1/2013
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-012-9634-6

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