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01-04-2009 | From Bench to Imaging

Molecular imaging of platelet activation in thrombus

Authors: François Rouzet, MD, Laure Sarda-Mantel, MD, PhD, Jean-Baptiste Michel, MD, PhD, Dominique Le Guludec, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 2/2009

Excerpt

Since its first use as a radiolabeled tracer for in vivo detection of platelet activation in an animal model of acute thrombosis in 1994,1 annexin V (Anx) generated a large body of literature. Because of its specific binding to phosphatidylserines (PS) externalized upon platelet activation and apoptosis, most of the work accomplished with radiolabeled Anx pertains to two domains: thrombus and programmed cell death. The latter is out of the scope of this review but contributed a lot to the improvement of Anx labeling with standardized procedures suitable for human utilization.2 …

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Title: Molecular imaging of platelet activation in thrombus
Authors: François Rouzet, MD
Laure Sarda-Mantel, MD, PhD
Jean-Baptiste Michel, MD, PhD
Dominique Le Guludec, MD, PhD
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: Journal of Nuclear Cardiology / Issue 2/2009
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-009-9053-5

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