Top

Published in:

01-06-2018 | Case Report

Refractory gastric antral ulcers without Helicobacter pylori infection and non-steroidal anti-inflammatory drugs

Authors: Hirotada Nishie, Hiromi Kataoka, Hiroyuki Kato, Taketo Suzuki, Hiroshi Ichikawa, Yu Nojiri, Mika Kitagawa, Yusuke Inagaki, Hiroyasu Iwasaki, Mamoru Tanaka, Takahito Katano, Yasuyuki Okamoto, Keiji Ozeki, Tsutomu Mizoshita, Takaya Shimura, Eiji Kubota, Satoshi Tanida, Takashi Joh

Published in: Clinical Journal of Gastroenterology | Issue 3/2018

Abstract

Herein, we describe a rare case of refractory gastric antral ulcers. A woman in her 50 s was admitted to Nagoya City University Hospital with epigastric pain after being diagnosed with gastric antral submucosal tumor at another hospital. Findings from esophagogastroduodenoscopy and endoscopic ultrasound examination revealed that the lesion was a gastric ulcer. The patient had no Helicobacter pylori infection and no recent history of using non-steroidal anti-inflammatory drugs. On the basis of these findings, we diagnosed this as a case of refractory gastric antral ulcer (RGAU). RGAU is considered a new disease concept and detailed analyses are expected in the future.

Ciociola AA, McSorley DJ, Turner K, Sykes D, Palmer JB. Helicobacter pylori infection rates in duodenal ulcer patients in the United States may be lower than previously estimated. Am J Gastroenterol. 1999;94:1834–40.CrossRefPubMed

Kanno T, et al. Helicobacter pylori-negative and non-steroidal anti-inflammatory drugs-negative idiopathic peptic ulcers show refractoriness and high recurrence incidence: multicenter follow-up study of peptic ulcers in Japan. Dig Endosc. 2016;28:556–63.CrossRefPubMed

Yamane T, et al. Refractory gastric antral ulcer of unknown etiology. Diges Endosc. 2008;20:203–6.CrossRef

Malfertheiner P, Chan FK, McColl KE. Peptic ulcer disease. Lancet. 2009;374:1449–61.CrossRefPubMed

Yamane T, Umeda A, Shimao H, Ishii T. A Case of refractory gastric cardia ulcer in which marked elevation of the surrounding mucosa was observed during the clinical course. Gastroenterol Res. 2013;6:106–9.

Iijima K, Kanno T, Koike T, Shimosegawa T. Helicobacter pylori-negative, non-steroidal anti-inflammatory drug: negative idiopathic ulcers in Asia. World J Gastroenterol. 2014;20:706–13.CrossRefPubMedPubMedCentral

Chung CS, Chiang TH, Lee YC. A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers. Korean J Intern Med. 2015;30:559–70.CrossRefPubMedPubMedCentral

Huang JQ, Sridhar S, Hunt RH. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. Lancet. 2002;359:14–22.CrossRefPubMed

Bento-Miranda M, Figueiredo C. Helicobacter heilmannii sensu lato: an overview of the infection in humans. World J Gastroenterol. 2014;20:17779–87.CrossRefPubMedPubMedCentral

10.

Goji S, et al. Helicobacter suis-infected nodular gastritis and a review of diagnostic sensitivity for Helicobacter heilmannii-like organisms. Case Rep Gastroenterol. 2015;9:179–87.CrossRefPubMedPubMedCentral

11.

Meucci G, et al. Prevalence and risk factors of Helicobacter pylori-negative peptic ulcer: a multicenter study. J Clin Gastroenterol. 2000;31:42–7.CrossRefPubMed

12.

Iijima K, et al. Preferential location of idiopathic peptic ulcers. Scand J Gastroenterol. 2016;51:782–7.CrossRefPubMed

13.

Hung LC, et al. Long-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: a prospective cohort study. Gastroenterology. 2005;128:1845–50.CrossRefPubMed

14.

Wong GL, et al. High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers. Gastroenterology. 2009;137:525–31.CrossRefPubMed

15.

Kanno T, et al. A multicenter prospective study on the prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drugs-negative idiopathic peptic ulcers in Japan. J Gastroenterol Hepatol. 2015;30:842–8.CrossRefPubMed

16.

Yamane T, Ishii T, Umeda A, Shimao H. Evaluation of six cases of idiopathic gastric antral ulcer. Gastroenterol Res. 2012;5:120–6.

Title: Refractory gastric antral ulcers without Helicobacter pylori infection and non-steroidal anti-inflammatory drugs
Authors: Hirotada Nishie
Hiromi Kataoka
Hiroyuki Kato
Taketo Suzuki
Hiroshi Ichikawa
Yu Nojiri
Mika Kitagawa
Yusuke Inagaki
Hiroyasu Iwasaki
Mamoru Tanaka
Takahito Katano
Yasuyuki Okamoto
Keiji Ozeki
Tsutomu Mizoshita
Takaya Shimura
Eiji Kubota
Satoshi Tanida
Takashi Joh
Publication date: 01-06-2018
Publisher: Springer Japan
Published in: Clinical Journal of Gastroenterology / Issue 3/2018
Print ISSN: 1865-7257
Electronic ISSN: 1865-7265
DOI: https://doi.org/10.1007/s12328-018-0835-7

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Refractory gastric antral ulcers without Helicobacter pylori infection and non-steroidal anti-inflammatory drugs

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2018

Postoperative recurrence from tract seeding after use of EUS–FNA for preoperative diagnosis of cancer in pancreatic tail

A case of small intestinal neuroendocrine carcinoma diagnosed using double-balloon endoscopy with long-term survival

Hepatic portal venous gas due to polystyrene sulfonate-induced enteritis

Correction to: Diagnostic significance of SPACE for PCIS

A case of pancreatic AV malformation in an elderly man

Granular cell tumor of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page