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Published in: Clinical Journal of Gastroenterology 1/2013

01-02-2013 | Case Report

A case of malignant melanoma simultaneously found in the lung and small intestine

Authors: Takayuki Nakagawa, Yoichi Yasuda, Seiji Sugiyama, Kensaku Yoshida, Hirokazu Adachi, Yosuke Osawa, Kengo Matsunaga, Hiroshi Sugiyama

Published in: Clinical Journal of Gastroenterology | Issue 1/2013

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Abstract

Metastatic melanoma in the small bowel is a common cause of secondary intestinal tumors. We present a case of a 77-year-old man with melena resulting from melanoma in the small bowel that was simultaneously found with malignant melanoma in the lung. Abdominal contrast-enhanced computed tomography (CT) and position emission tomography (PET) revealed a 30 × 20 mm hypervascular lesion in the small bowel and a 9 × 9 mm right lobe lung mass with metastasis in the mediastinal and peritoneal lymph nodes, and the spleen. The bowel and lung tumor lesions were confirmed by enteroscopy and bronchoscopy, respectively, and were histologically diagnosed as malignant melanoma. In cases of small bowel malignant melanoma, an extraintestinal origin should always be suspected because intestinal melanomas are almost always metastatic. PET/CT is an effective tool for confirming intestinal melanomas because of its high sensitivity and specificity.
Literature
1.
go back to reference Blecker D, Abraham S, Furth EE, Kochman ML. Melanoma in the gastrointestinal tract. Am J Gastroenterol. 1999;94:3427–33.PubMedCrossRef Blecker D, Abraham S, Furth EE, Kochman ML. Melanoma in the gastrointestinal tract. Am J Gastroenterol. 1999;94:3427–33.PubMedCrossRef
2.
go back to reference Kadakia SC, Parker A, Canales L. Metastatic tumors to the upper gastrointestinal tract: endoscopic experience. Am J Gastroenterol. 1992;87:1418–23.PubMed Kadakia SC, Parker A, Canales L. Metastatic tumors to the upper gastrointestinal tract: endoscopic experience. Am J Gastroenterol. 1992;87:1418–23.PubMed
3.
4.
go back to reference Reddy VS, Mykytenko J, Giltman LI, Mansour KA. Primary malignant melanoma of the lung: review of literature and report of a case. Am Surg. 2007;73:287–9.PubMed Reddy VS, Mykytenko J, Giltman LI, Mansour KA. Primary malignant melanoma of the lung: review of literature and report of a case. Am Surg. 2007;73:287–9.PubMed
5.
go back to reference Neri S, Komatsu T, Kitamura J, Otsuka K, Katakami N, Takahashi Y. Malignant melanoma of the lung: report of two cases. Ann Thorac Cardiovasc Surg. 2011;17:170–3.PubMedCrossRef Neri S, Komatsu T, Kitamura J, Otsuka K, Katakami N, Takahashi Y. Malignant melanoma of the lung: report of two cases. Ann Thorac Cardiovasc Surg. 2011;17:170–3.PubMedCrossRef
6.
go back to reference Kundranda MN, Clark CT, Chaudhry AA, Chan V, Daw HA. Primary malignant melanoma of the lung: a case report and review of the literature. Clin Lung Cancer. 2006;7:279–81.PubMedCrossRef Kundranda MN, Clark CT, Chaudhry AA, Chan V, Daw HA. Primary malignant melanoma of the lung: a case report and review of the literature. Clin Lung Cancer. 2006;7:279–81.PubMedCrossRef
7.
go back to reference Wilson RW, Moran CA. Primary melanoma of the lung: a clinicopathologic and immunohistochemical study of eight cases. Am J Surg Pathol. 1997;21:1196–202.PubMedCrossRef Wilson RW, Moran CA. Primary melanoma of the lung: a clinicopathologic and immunohistochemical study of eight cases. Am J Surg Pathol. 1997;21:1196–202.PubMedCrossRef
8.
go back to reference Kadivar TF, Vanek VW, Krishnan EU. Primary malignant melanoma of the small bowel: a case study. Am Surg. 1992;58:418–22.PubMed Kadivar TF, Vanek VW, Krishnan EU. Primary malignant melanoma of the small bowel: a case study. Am Surg. 1992;58:418–22.PubMed
9.
go back to reference Patel JK, Didolkar MS, Pickren JW, Moore RH. Metastatic pattern of malignant melanoma. A study of 216 autopsy cases. Am J Surg. 1978;135:807–10.PubMedCrossRef Patel JK, Didolkar MS, Pickren JW, Moore RH. Metastatic pattern of malignant melanoma. A study of 216 autopsy cases. Am J Surg. 1978;135:807–10.PubMedCrossRef
10.
go back to reference Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998;83:1664–78.PubMedCrossRef Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998;83:1664–78.PubMedCrossRef
11.
go back to reference Dountsis A, Zisis C, Karagianni E, Dahabreh J. Primary malignant melanoma of the lung: a case report. World J Surg Oncol. 2003;1:26–9.PubMedCrossRef Dountsis A, Zisis C, Karagianni E, Dahabreh J. Primary malignant melanoma of the lung: a case report. World J Surg Oncol. 2003;1:26–9.PubMedCrossRef
12.
go back to reference Crippa S, Bovo G, Romano F, Mussi C, Uggeri F. Melanoma metastatic to the gallbladder and small bowel: report of a case and review of the literature. Melanoma Res. 2004;14:427–30.PubMedCrossRef Crippa S, Bovo G, Romano F, Mussi C, Uggeri F. Melanoma metastatic to the gallbladder and small bowel: report of a case and review of the literature. Melanoma Res. 2004;14:427–30.PubMedCrossRef
13.
go back to reference Backman H, Davidsson L. Metastases of malignant melanoma in the stomach and small intestine. Acta Med Scand. 1965;178:329–35.PubMedCrossRef Backman H, Davidsson L. Metastases of malignant melanoma in the stomach and small intestine. Acta Med Scand. 1965;178:329–35.PubMedCrossRef
14.
go back to reference Elsayed AM, Albahra M, Nzeako UC, Sobin LH. Malignant melanomas in the small intestine: a study of 103 patients. Am J Gastroenterol. 1996;91:1001–6.PubMed Elsayed AM, Albahra M, Nzeako UC, Sobin LH. Malignant melanomas in the small intestine: a study of 103 patients. Am J Gastroenterol. 1996;91:1001–6.PubMed
15.
go back to reference Schuchter LM, Green R, Fraker D. Primary and metastatic diseases in malignant melanoma of the gastrointestinal tract. Curr Opin Oncol. 2000;12:181–5.PubMedCrossRef Schuchter LM, Green R, Fraker D. Primary and metastatic diseases in malignant melanoma of the gastrointestinal tract. Curr Opin Oncol. 2000;12:181–5.PubMedCrossRef
16.
go back to reference Liang KV, Sanderson SO, Nowakowski GS, Arora AS. Metastatic malignant melanoma of the gastrointestinal tract. Mayo Clin Proc. 2006;81:511–6.PubMedCrossRef Liang KV, Sanderson SO, Nowakowski GS, Arora AS. Metastatic malignant melanoma of the gastrointestinal tract. Mayo Clin Proc. 2006;81:511–6.PubMedCrossRef
17.
go back to reference Bender GN, Maglinte DD, McLarney JH, Rex D, Kelvin FM. Malignant melanoma: patterns of metastasis to the small bowel, reliability of imaging studies, and clinical relevance. Am J Gastroenterol. 2001;96:2392–400.PubMed Bender GN, Maglinte DD, McLarney JH, Rex D, Kelvin FM. Malignant melanoma: patterns of metastasis to the small bowel, reliability of imaging studies, and clinical relevance. Am J Gastroenterol. 2001;96:2392–400.PubMed
18.
go back to reference Tatlidil R, Mandelkern M. FDG-PET in the detection of gastrointestinal metastases in melanoma. Melanoma Res. 2001;11:297–301.PubMedCrossRef Tatlidil R, Mandelkern M. FDG-PET in the detection of gastrointestinal metastases in melanoma. Melanoma Res. 2001;11:297–301.PubMedCrossRef
19.
go back to reference Strobel K, Skalsky J, Hany TF, Dummer R, Steinert HC. Small bowel invagination caused by intestinal melanoma metastasis: unsuspected diagnosis by FDG-PET/CT imaging. Clin Nucl Med. 2007;32:213–4.PubMedCrossRef Strobel K, Skalsky J, Hany TF, Dummer R, Steinert HC. Small bowel invagination caused by intestinal melanoma metastasis: unsuspected diagnosis by FDG-PET/CT imaging. Clin Nucl Med. 2007;32:213–4.PubMedCrossRef
20.
go back to reference Kamel EM, Thumshirn M, Truninger K, Schiesser M, Fried M, Padberg B, Schneiter D, et al. Significance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic results. J Nucl Med. 2004;45:1804–10.PubMed Kamel EM, Thumshirn M, Truninger K, Schiesser M, Fried M, Padberg B, Schneiter D, et al. Significance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic results. J Nucl Med. 2004;45:1804–10.PubMed
21.
go back to reference Albert JG, Gimm O, Stock K, Bilkenroth U, Marsch WC, Helmbold P. Small-bowel endoscopy is crucial for diagnosis of melanoma metastases to the small bowel: a case of metachronous small-bowel metastases and review of the literature. Melanoma Res. 2007;17:335–8.PubMedCrossRef Albert JG, Gimm O, Stock K, Bilkenroth U, Marsch WC, Helmbold P. Small-bowel endoscopy is crucial for diagnosis of melanoma metastases to the small bowel: a case of metachronous small-bowel metastases and review of the literature. Melanoma Res. 2007;17:335–8.PubMedCrossRef
Metadata
Title
A case of malignant melanoma simultaneously found in the lung and small intestine
Authors
Takayuki Nakagawa
Yoichi Yasuda
Seiji Sugiyama
Kensaku Yoshida
Hirokazu Adachi
Yosuke Osawa
Kengo Matsunaga
Hiroshi Sugiyama
Publication date
01-02-2013
Publisher
Springer Japan
Published in
Clinical Journal of Gastroenterology / Issue 1/2013
Print ISSN: 1865-7257
Electronic ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-012-0350-1

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