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Open Access 01-10-2020 | Review

Advances in Topical Hemostatic Agent Therapies: A Comprehensive Update

Authors: Liang Huang, Geoffrey L. Liu, Alan D. Kaye, Henry Liu

Published in: Advances in Therapy | Issue 10/2020

Abstract

Severe hemorrhage causes significant metabolic and cellular dysfunction secondary to deficient tissue perfusion and oxygen delivery. If bleeding continues, hemodynamic destabilization, hypoxemia, multiple organ failure, and death will occur. Techniques employed to promote hemostasis include surgical suture ligatures, cautery, chemical agents, self-assembling nanoparticles, and physical methods, like mechanical pressure. Improved understanding of the natural clotting cascade has allowed newly designed agents to become more targeted for clinical and military use. Topically-applied hemostatic agents have enormous clinical applications in achieving hemostasis. This manuscript describes currently available and developing topical hemostatic materials, including topical active agents, mechanical agents, synthetic/hemisynthetic hemostatic agents, and external hemostatic dressings for clinical practice.

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Title: Advances in Topical Hemostatic Agent Therapies: A Comprehensive Update
Authors: Liang Huang
Geoffrey L. Liu
Alan D. Kaye
Henry Liu
Publication date: 01-10-2020
Publisher: Springer Healthcare
Published in: Advances in Therapy / Issue 10/2020
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI: https://doi.org/10.1007/s12325-020-01467-y

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