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Advances in Therapy
Published in: Advances in Therapy 6/2019

Open Access 01-06-2019 | Analgesics in Dentistry | Letter

Response to “A Rigorous Evaluation of Methoxyflurane is Needed: Comment on ‘Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA)’”

Authors: Andrea Fabbri, Giuseppe Carpinteri, Germana Ruggiano, Elisabetta Bonafede, Antonella Sblendido, Alberto Farina, Amedeo Soldi

Published in: Advances in Therapy | Issue 6/2019

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Excerpt

We welcome the critical review by Montassier and Freund on our article on the rationale and methods of the “MEDITA” study [1]. Below, we provide point-by-point answers to all comments. …
Literature
1.
Fabbri A, Carpinteri G, Ruggiano G, Bonafede E, Sblendido A, Farina A, Soldi A, MEDITA Study Group. Methoxyflurane versus standard of care for acute trauma-related pain in the emergency setting: protocol for a randomised, controlled study in Italy (MEDITA). Adv Ther. 2019;36(1):244–56.CrossRefPubMed
2.
Coffey F, Wright J, Hartshorn S, Hunt P, Locker T, Mirza K, Dissmann P. STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain. Emerg Med J. 2014;31(8):613–8.CrossRefPubMedPubMedCentral
3.
Borobia Pe´rez AM, Capilla Pueyo R, Casal Codesido JR, InMEDIATE Group, et al. Phase IIIb, open label randomised clinical trial to compare pain relief between methoxyflurane and standard of care for treating patients with trauma pain in Spanish Emergency Units (InMEDIATE): study protocol. IBJ Clin Pharmacol. 2017;1:e0008.
4.
Borobia Pérez A, García Collado S, Carballo Cardona C, Capilla Pueyo R, Fernández Alonso C, Pérez Torres I, et al. InMEDIATE: results of a phase IIIB, open label randomised clinical trial to compare pain relief between methoxyflurane and standard of care analgesia for treating patients with trauma pain in Spanish emergency departments. Basic Clin Pharmacol Toxicol. 2018;123(Suppl. 4):16.
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Metadata
Title
Response to “A Rigorous Evaluation of Methoxyflurane is Needed: Comment on ‘Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA)’”
Authors
Andrea Fabbri
Giuseppe Carpinteri
Germana Ruggiano
Elisabetta Bonafede
Antonella Sblendido
Alberto Farina
Amedeo Soldi
Publication date
01-06-2019
Publisher
Springer Healthcare
Published in
Advances in Therapy / Issue 6/2019
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI
https://doi.org/10.1007/s12325-019-00937-2

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