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01-03-2018 | Commentary

Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

Authors: Missak Haigentz Jr., Carlos Suarez, Primoz Strojan, Juan P. Rodrigo, Alessandra Rinaldo, Carol R. Bradford, June Corry, Robert P. Takes, Alfio Ferlito

Published in: Advances in Therapy | Issue 3/2018

Abstract

The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.

Amin MB, Edge S, Greene F et al, editors. AJCC cancer staging manual. 8th ed. New York: Springer; 2017.

Kumar B, Cordell KG, Lee JS, et al. EGFR, p16, HPV titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol. 2008;26:3128–37.CrossRefPubMedPubMedCentral

Maxwell JH, Kumar B, Feng FY, et al. Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res. 2010;16:1226–35.CrossRefPubMedPubMedCentral

O’Sullivan B, Huang SH, Siu LL, et al. Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol. 2013;31:543–50.CrossRefPubMed

Vainshtein JM, Spector ME, McHugh JB, et al. Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer. Oral Oncol. 2014;50:513–9.CrossRefPubMedPubMedCentral

Marur S, Li S, Cmelak AJ, Gillison ML, et al. E1308: phase II trial of induction chemotherapy followed by reduced-dose radiation and weekly cetuximab in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx—ECOG-ACRIN Cancer Research Group. J Clin Oncol. 2017;35:490–7.CrossRefPubMed

Platek AJ, Jayaprakash V, Merzianu M, et al. Smoking cessation is associated with improved survival in oropharynx cancer treated by chemoradiation. Laryngoscope. 2016;126:2733–8.CrossRefPubMed

Liskamp CP, Janssens GO, Bussink J, Melchers WJ, Kaanders JH, Verhoef CG. Adverse effect of smoking on prognosis in human papillomavirus-associated oropharyngeal carcinoma. Head Neck. 2016;38:1780–7.CrossRefPubMed

The Cancer Genome Atlas Network. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517:576–82.CrossRefPubMedCentral

10.

Hong A, Zhang X, Jones D, et al. Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma. Radiother Oncol. 2016;118:342–9.CrossRefPubMed

11.

Qiu F, Liang CL, Liu H, et al. Impacts of cigarette smoking on immune responsiveness: up and down or upside down? Oncotarget. 2017;8:268–84.PubMed

12.

Samuels SE, Eisbruch A, Beitler JJ, et al. Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we? Eur Arch Otorhinolaryngol. 2016;273:2877–94.CrossRefPubMed

13.

Petros WP, Younis IR, Ford JN, Weed SA. Effects of tobacco smoking and nicotine on cancer treatment. Pharmacotherapy. 2012;32:920–31.CrossRefPubMed

14.

Bøje CR. Impact of comorbidity on treatment outcome in head and neck squamous cell carcinoma—a systematic review. Radiother Oncol. 2014;110:81–90.CrossRefPubMed

15.

16.

van der Schroeff MP, van de Schans SA, Piccirillo JF, Langeveld TP, Baatenburg de Jong RJ, Janssen-Heijnen ML. Conditional relative survival in head and neck squamous cell carcinoma: permanent excess mortality risk for long-term survivors. Head Neck. 2010;32:1613–8.CrossRefPubMed

17.

Takes RP, Rinaldo A, Silver CE, et al. Future of the TNM classification and staging system in head and neck cancer. Head Neck. 2010;32:1693–711.CrossRefPubMed

18.

Chu KP, Habbous S, Kuang Q, et al. Socioeconomic status, human papillomavirus, and overall survival in head and neck squamous cell carcinomas in Toronto, Canada. Cancer Epidemiol. 2016;40:102–12.CrossRefPubMed

19.

Sterba KR, Garrett-Mayer E, Carpenter MJ, et al. Smoking status and symptom burden in surgical head and neck cancer patients. Laryngoscope. 2017;127:127–33.CrossRefPubMed

20.

Prochaska JJ, Das S, Young-Wolff KC. Smoking, mental illness, and public health. Annu Rev Public Health. 2017;38:165–85.CrossRefPubMed

21.

Mdodo R, Frazier EL, Dube SR, et al. Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys. Ann Intern Med. 2015;162:335–44.CrossRefPubMed

22.

Maier H, Zöller J, Herrmann A, Kreiss M, Heller WD. Dental status and oral hygiene in patients with head and neck cancer. Otolaryngol Head Neck Surg. 1993;108:655–61.CrossRefPubMed

23.

Teppo H, Alho OP. Comorbidity and diagnostic delay in cancer of the larynx, tongue and pharynx. Oral Oncol. 2009;45:692–5.CrossRefPubMed

24.

Walline HM, Komarck C, McHugh JB, et al. High-risk human papillomavirus detection in oropharyngeal, nasopharyngeal, and oral cavity cancers: comparison of multiple methods. JAMA Otolaryngol Head Neck Surg. 2013;139:1320–7.CrossRefPubMedPubMedCentral

25.

Nauta IH, Rietbergen MM, Vanbokhoven AAJD, et al. Evaluation of the 8th TNM classification on p16-positive oropharyngeal squamous cell carcinomas in the Netherlands, and the importance of additional HPV DNA-testing. Ann Oncol. 2018. https://doi.org/10.1093/annonc/mdy060.PubMed

26.

Rietbergen MM, Snijders PJ, Beekzada D, et al. Molecular characterization of p16-immunopositive but HPV DNA-negative oropharyngeal carcinomas. Int J Cancer. 2014;134:2366–72.CrossRefPubMed

Title: Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers
Authors: Missak Haigentz Jr.
Carlos Suarez
Primoz Strojan
Juan P. Rodrigo
Alessandra Rinaldo
Carol R. Bradford
June Corry
Robert P. Takes
Alfio Ferlito
Publication date: 01-03-2018
Publisher: Springer Healthcare
Published in: Advances in Therapy / Issue 3/2018
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI: https://doi.org/10.1007/s12325-018-0682-4

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